STRINGSTRING
LARGE1 LARGE1 NR0B2 NR0B2 ELAVL4 ELAVL4 PTGFRN PTGFRN BCL9 BCL9 TNR TNR LGR6 LGR6 UPF2 UPF2 MKI67 MKI67 ADM ADM MYOD1 MYOD1 FOLR1 FOLR1 UCP2 UCP2 YAP1 YAP1 NNMT NNMT APOA5 APOA5 APOA4 APOA4 CD9 CD9 WNT10B WNT10B WNT1 WNT1 FLT3 FLT3 CPB2 CPB2 LCP1 LCP1 SRSF5 SRSF5 SERPINA10 SERPINA10 SLC7A5 SLC7A5 RTN4RL1 RTN4RL1 SOX15 SOX15 OMG OMG MED1 MED1 TYMS TYMS HAMP HAMP TGFB1 TGFB1 TMEM182 TMEM182 MSTN MSTN IHH IHH PCNA PCNA AURKA AURKA HMOX1 HMOX1 LAMB2 LAMB2 DAG1 DAG1 MUSTN1 MUSTN1 GAP43 GAP43 KPNA1 KPNA1 TM4SF4 TM4SF4 CLDN1 CLDN1 ANXA3 ANXA3 CCNA2 CCNA2 ISL1 ISL1 MAP1B MAP1B DHFR DHFR CTNNA1 CTNNA1 PLG PLG IGFBP1 IGFBP1 PTPN12 PTPN12 ANGPT2 ANGPT2 CCN3 CCN3 NINJ1 NINJ1 TNC TNC NOTCH1 NOTCH1 RGN RGN ADAM15 ADAM15 ATIC ATIC TSPO TSPO IFRD1 IFRD1 MTPN MTPN MYMK MYMK SOX2 SOX2 FZD9 FZD9 CD22-2 CD22-2 ANXA1 ANXA1 BAK1 BAK1 TARBP2 TARBP2 CDK1 CDK1 MTR MTR SGCA SGCA CSNK2A2 CSNK2A2 IFRD2 IFRD2 BIN3 BIN3 PGF PGF CDKN1A CDKN1A KLF5 KLF5 RTN4RL2 RTN4RL2 ENSPTRP00000062077 ENSPTRP00000062077 GFAP GFAP IGF2R IGF2R ERBB4 ERBB4 PRMT5 PRMT5 CK820_G0046635 CK820_G0046635 WNT7A WNT7A TGFBR3 TGFBR3 TEC-2 TEC-2 PPP3CA PPP3CA IGF1 IGF1 CXCL12 CXCL12 IL6 IL6 CK820_G0051040 CK820_G0051040 GFER GFER PTPN3 PTPN3 DMD DMD ENSPTRP00000069878 ENSPTRP00000069878 AKIRIN1 AKIRIN1 ENSPTRP00000070684 ENSPTRP00000070684 CPQ CPQ CPT1A CPT1A PTPRU PTPRU TEC TEC KLK6 KLK6 ENSPTRP00000072249 ENSPTRP00000072249 HGF HGF LPIN1 LPIN1 PTPRF PTPRF RGN-2 RGN-2 ENSPTRP00000074270 ENSPTRP00000074270 CD81 CD81 ENSPTRP00000074929 ENSPTRP00000074929 TGFBR2 TGFBR2 GATA4 GATA4 ENSPTRP00000075906 ENSPTRP00000075906 NINJ2 NINJ2 NEFL NEFL PPARG PPARG ENSPTRP00000076749 ENSPTRP00000076749 EZH2 EZH2 GLI1 GLI1 ENSPTRP00000078515 ENSPTRP00000078515 CFLAR CFLAR MYMX MYMX TXK-2 TXK-2 PFKFB1 PFKFB1 IL6-2 IL6-2 APOD APOD PTN PTN ENSPTRP00000081721 ENSPTRP00000081721 JAK2 JAK2 CSPG5 CSPG5 FGF10 FGF10 NR4A3 NR4A3 ENSPTRP00000084090 ENSPTRP00000084090 PNPT1 PNPT1 DMD-2 DMD-2 MDK MDK TXK TXK FPGS FPGS CEBPB CEBPB ENSPTRP00000085831 ENSPTRP00000085831 CCND1 CCND1 SELENON SELENON GATA1 GATA1 HDGFL2 HDGFL2 AXL AXL EYS EYS PTCH1 PTCH1 MMP2 MMP2 ENSPTRP00000087800 ENSPTRP00000087800 FZD7 FZD7 ENSPTRP00000089676 ENSPTRP00000089676 BAAT BAAT BCL2 BCL2 EZH2-2 EZH2-2 NREP NREP ENSPTRP00000091066 ENSPTRP00000091066 ENSPTRP00000091596 ENSPTRP00000091596 MAPK8IP3 MAPK8IP3 ENSPTRP00000092743 ENSPTRP00000092743 RUNX1 RUNX1 PRPS2 PRPS2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LARGE1LARGE xylosyl- and glucuronyltransferase 1. (756 aa)
NR0B2Nuclear receptor subfamily 0 group B member 2. (257 aa)
ELAVL4ELAV-like protein; Belongs to the RRM elav family. (402 aa)
PTGFRNProstaglandin F2 receptor negative regulator. (879 aa)
BCL9BCL9 transcription coactivator. (1426 aa)
TNRTNR isoform 1. (1358 aa)
LGR6LGR6 isoform 2. (967 aa)
UPF2UPF2 regulator of nonsense mediated mRNA decay. (1272 aa)
MKI67MKI67 isoform 1. (3257 aa)
ADMAdrenomedullin. (185 aa)
MYOD1Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (320 aa)
FOLR1Folate receptor alpha. (257 aa)
UCP2Uncoupling protein 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (309 aa)
YAP1Yes-associated protein 1. (508 aa)
NNMTNicotinamide N-methyltransferase. (264 aa)
APOA5Apolipoprotein A5. (366 aa)
APOA4Apolipoprotein A4. (396 aa)
CD9Tetraspanin. (228 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (993 aa)
CPB2Carboxypeptidase B2. (423 aa)
LCP1Lymphocyte cytosolic protein 1. (627 aa)
SRSF5Serine and arginine rich splicing factor 5. (272 aa)
SERPINA10SERPINA10 isoform 2; Belongs to the serpin family. (484 aa)
SLC7A5SLC7A5 isoform 2. (507 aa)
RTN4RL1Reticulon-4 receptor-like 1. (441 aa)
SOX15SOX15 isoform 1. (233 aa)
OMGOligodendrocyte myelin glycoprotein. (440 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1581 aa)
TYMSThymidylate synthetase. (313 aa)
HAMPHepcidin antimicrobial peptide. (84 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
TMEM182Transmembrane protein 182. (229 aa)
MSTNGrowth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth; Belongs to the TGF-beta family. (376 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
AURKASerine/threonine-protein kinase 6; Belongs to the protein kinase superfamily. (403 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (311 aa)
LAMB2Laminin, beta 2 (Laminin S). (1798 aa)
DAG1Dystroglycan 1 (Dystrophin-associated glycoprotein 1). (895 aa)
MUSTN1Musculoskeletal embryonic nuclear protein 1 isoform X1. (87 aa)
GAP43Neuromodulin; This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction (By similarity). (274 aa)
KPNA1Importin subunit alpha; Functions in nuclear protein import. (538 aa)
TM4SF4Transmembrane 4 L six family member 4. (202 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
ANXA3Annexin. (323 aa)
CCNA2CCNA2 isoform 1; Belongs to the cyclin family. (432 aa)
ISL1ISL LIM homeobox 1. (349 aa)
MAP1BMicrotubule associated protein 1B. (2468 aa)
DHFRDihydrofolate reductase; Belongs to the dihydrofolate reductase family. (187 aa)
CTNNA1CTNNA1 isoform 21. (906 aa)
PLGPlasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (813 aa)
IGFBP1IGFBP1 isoform 1. (281 aa)
PTPN12Tyrosine-protein phosphatase non-receptor type 12; Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades. (780 aa)
ANGPT2ANGPT2 isoform 1. (496 aa)
CCN3NOV isoform 1. (357 aa)
NINJ1NINJ1 isoform 1. (152 aa)
TNCTNC isoform 1. (2201 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
RGNRegucalcin (Senescence marker protein-30). (299 aa)
ADAM15ADAM metallopeptidase domain 15. (863 aa)
ATIC5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. (592 aa)
TSPOTranslocator protein. (169 aa)
IFRD1Interferon-related developmental regulator 1. (452 aa)
MTPNMTPN isoform 1. (118 aa)
MYMKMyomaker, myoblast fusion factor. (221 aa)
SOX2SRY-box transcription factor 2. (319 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa)
CD22-2B-cell receptor CD22. (626 aa)
ANXA1Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of Fthe formyl peptide receptors (By similarity). Contribu [...] (346 aa)
BAK1BCL2-antagonist/killer 1. (211 aa)
TARBP2RISC-loading complex subunit TARBP2; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from [...] (366 aa)
CDK1Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
MTRMethionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1267 aa)
SGCASarcoglycan, alpha (50kDa dystrophin-associated glycoprotein). (387 aa)
CSNK2A2Casein kinase 2, alpha prime polypeptide; Belongs to the protein kinase superfamily. (350 aa)
IFRD2Interferon-related developmental regulator 2. (510 aa)
BIN3Bridging integrator 3. (253 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (221 aa)
CDKN1ACyclin-dependent kinase inhibitor 1A (P21, Cip1). (276 aa)
KLF5Kruppel-like factor 5 (Intestinal). (457 aa)
RTN4RL2Reticulon 4 receptor like 2. (420 aa)
ENSPTRP00000062077annotation not available (236 aa)
GFAPGlial fibrillary acidic protein; Belongs to the intermediate filament family. (505 aa)
IGF2RIGF2R isoform 2. (2491 aa)
ERBB4Receptor protein-tyrosine kinase. (1386 aa)
PRMT5Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily. (620 aa)
CK820_G0046635NACA isoform 1. (1839 aa)
WNT7AProtein Wnt-7a; Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta- catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes. Required for normal [...] (349 aa)
TGFBR3Transforming growth factor, beta receptor III. (861 aa)
TEC-2Tec protein tyrosine kinase. (51 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
IGF1Insulin-like growth factor 1 (Somatomedin C). (196 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (140 aa)
IL6Interleukin 6 (Interferon, beta 2). (234 aa)
CK820_G0051040EYS isoform 4. (318 aa)
GFERSulfhydryl oxidase. (204 aa)
PTPN3Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton. (1027 aa)
DMDDMD isoform 3. (3685 aa)
ENSPTRP00000069878annotation not available (125 aa)
AKIRIN1AKIRIN1 isoform 1. (216 aa)
ENSPTRP00000070684annotation not available (183 aa)
CPQPlasma glutamate carboxypeptidase. (471 aa)
CPT1ACarnitine palmitoyltransferase 1A (Liver); Belongs to the carnitine/choline acetyltransferase family. (773 aa)
PTPRUProtein tyrosine phosphatase receptor type U. (1454 aa)
TECTyrosine-protein kinase. (631 aa)
KLK6Kallikrein related peptidase 6; Belongs to the peptidase S1 family. (244 aa)
ENSPTRP00000072249annotation not available (396 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (812 aa)
LPIN1LPIN1 isoform 7. (975 aa)
PTPRFProtein tyrosine phosphatase, receptor type, F. (1914 aa)
RGN-2Regucalcin. (299 aa)
ENSPTRP00000074270annotation not available (297 aa)
CD81CD81 antigen; Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Essential for trafficking and compartmentalization of CD19 receptor on the surface of activated B cells. Upon initial encounter with microbial pathogens, enables the assembly of CD19-CR2/CD21 and B cell receptor (BCR) complexes at signaling TERMs, lowering the threshold dose of antigen required to trigger B cell clonal expansion and antibody production. In T cells, facilitates the localization of CD247/ [...] (303 aa)
ENSPTRP00000074929annotation not available (367 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (581 aa)
GATA4GATA binding protein 4. (443 aa)
ENSPTRP00000075906annotation not available (68 aa)
NINJ2NINJ2 isoform 1. (188 aa)
NEFLNeurofilament light; Belongs to the intermediate filament family. (543 aa)
PPARGPeroxisome proliferator-activated receptor gamma isoform X2. (505 aa)
ENSPTRP00000076749annotation not available (243 aa)
EZH2Enhancer of zeste homolog 2. (754 aa)
GLI1GLI family zinc finger 1. (1106 aa)
ENSPTRP00000078515annotation not available (198 aa)
CFLARCASP8 and FADD-like apoptosis regulator; Belongs to the peptidase C14A family. (480 aa)
MYMXMyomixer, myoblast fusion factor. (84 aa)
TXK-2TXK tyrosine kinase. (530 aa)
PFKFB16-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1. (471 aa)
IL6-2Interleukin 6. (234 aa)
APODApolipoprotein D. (215 aa)
PTNPTN isoform 2. (172 aa)
ENSPTRP00000081721annotation not available (70 aa)
JAK2Tyrosine-protein kinase. (1143 aa)
CSPG5Chondroitin sulfate proteoglycan 5. (566 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (637 aa)
ENSPTRP00000084090annotation not available (121 aa)
PNPT1Polyribonucleotide nucleotidyltransferase 1. (784 aa)
DMD-2Dystrophin. (643 aa)
MDKMidkine (Neurite growth-promoting factor 2). (143 aa)
TXKTyrosine-protein kinase. (527 aa)
FPGSFolylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. (587 aa)
CEBPBCCAAT/enhancer-binding protein. (347 aa)
ENSPTRP00000085831annotation not available (79 aa)
CCND1CCND1 isoform 1; Belongs to the cyclin family. (295 aa)
SELENONT0161445 isoform 2. (581 aa)
GATA1GATA binding protein 1. (413 aa)
HDGFL2Hepatoma-derived growth factor-related protein 2. (670 aa)
AXLAXL receptor tyrosine kinase. (894 aa)
EYSEYS isoform 1. (3144 aa)
PTCH1PTCH1 isoform 8. (1428 aa)
MMP2Matrix metallopeptidase 2. (660 aa)
ENSPTRP00000087800annotation not available (170 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
ENSPTRP00000089676annotation not available (850 aa)
BAATBile acid-CoA:amino acid N-acyltransferase. (418 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
EZH2-2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (751 aa)
NREPNeuronal regeneration related protein. (112 aa)
ENSPTRP00000091066annotation not available (366 aa)
ENSPTRP00000091596annotation not available (183 aa)
MAPK8IP3MAPK8IP3 isoform 2. (1314 aa)
ENSPTRP00000092743annotation not available (379 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa)
PRPS2Phosphoribosyl pyrophosphate synthetase 2. (321 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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