STRINGSTRING
PRMT5 PRMT5 PRPS2 PRPS2 ENSPTRP00000092743 ENSPTRP00000092743 EZH2-2 EZH2-2 BAAT BAAT PTCH1 PTCH1 AXL AXL GATA1 GATA1 CCND1 CCND1 CEBPB CEBPB FPGS FPGS PNPT1 PNPT1 NR4A3 NR4A3 IL6-2 IL6-2 PFKFB1 PFKFB1 ENSPTRP00000078515 ENSPTRP00000078515 GLI1 GLI1 EZH2 EZH2 ENSPTRP00000076749 ENSPTRP00000076749 PPARG PPARG TGFBR2 TGFBR2 RGN-2 RGN-2 LPIN1 LPIN1 HGF HGF PTPRU PTPRU CPT1A CPT1A PTPN3 PTPN3 GFER GFER IL6 IL6 CXCL12 CXCL12 TGFBR3 TGFBR3 IGF2R IGF2R ENSPTRP00000062077 ENSPTRP00000062077 PGF PGF CSNK2A2 CSNK2A2 CDK1 CDK1 BAK1 BAK1 ATIC ATIC RGN RGN NOTCH1 NOTCH1 ANGPT2 ANGPT2 CCNA2 CCNA2 ANXA3 ANXA3 CLDN1 CLDN1 HMOX1 HMOX1 AURKA AURKA PCNA PCNA IHH IHH TGFB1 TGFB1 HAMP HAMP TYMS TYMS MED1 MED1 SLC7A5 SLC7A5 SERPINA10 SERPINA10 SRSF5 SRSF5 LCP1 LCP1 CPB2 CPB2 FLT3 FLT3 WNT1 WNT1 NNMT NNMT UCP2 UCP2 ADM ADM MKI67 MKI67 UPF2 UPF2 NR0B2 NR0B2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRMT5Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily. (620 aa)
PRPS2Phosphoribosyl pyrophosphate synthetase 2. (321 aa)
ENSPTRP00000092743annotation not available (379 aa)
EZH2-2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (751 aa)
BAATBile acid-CoA:amino acid N-acyltransferase. (418 aa)
PTCH1PTCH1 isoform 8. (1428 aa)
AXLAXL receptor tyrosine kinase. (894 aa)
GATA1GATA binding protein 1. (413 aa)
CCND1CCND1 isoform 1; Belongs to the cyclin family. (295 aa)
CEBPBCCAAT/enhancer-binding protein. (347 aa)
FPGSFolylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. (587 aa)
PNPT1Polyribonucleotide nucleotidyltransferase 1. (784 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (637 aa)
IL6-2Interleukin 6. (234 aa)
PFKFB16-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1. (471 aa)
ENSPTRP00000078515annotation not available (198 aa)
GLI1GLI family zinc finger 1. (1106 aa)
EZH2Enhancer of zeste homolog 2. (754 aa)
ENSPTRP00000076749annotation not available (243 aa)
PPARGPeroxisome proliferator-activated receptor gamma isoform X2. (505 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (581 aa)
RGN-2Regucalcin. (299 aa)
LPIN1LPIN1 isoform 7. (975 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (812 aa)
PTPRUProtein tyrosine phosphatase receptor type U. (1454 aa)
CPT1ACarnitine palmitoyltransferase 1A (Liver); Belongs to the carnitine/choline acetyltransferase family. (773 aa)
PTPN3Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton. (1027 aa)
GFERSulfhydryl oxidase. (204 aa)
IL6Interleukin 6 (Interferon, beta 2). (234 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (140 aa)
TGFBR3Transforming growth factor, beta receptor III. (861 aa)
IGF2RIGF2R isoform 2. (2491 aa)
ENSPTRP00000062077annotation not available (236 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (221 aa)
CSNK2A2Casein kinase 2, alpha prime polypeptide; Belongs to the protein kinase superfamily. (350 aa)
CDK1Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
BAK1BCL2-antagonist/killer 1. (211 aa)
ATIC5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. (592 aa)
RGNRegucalcin (Senescence marker protein-30). (299 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
ANGPT2ANGPT2 isoform 1. (496 aa)
CCNA2CCNA2 isoform 1; Belongs to the cyclin family. (432 aa)
ANXA3Annexin. (323 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (311 aa)
AURKASerine/threonine-protein kinase 6; Belongs to the protein kinase superfamily. (403 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
HAMPHepcidin antimicrobial peptide. (84 aa)
TYMSThymidylate synthetase. (313 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1581 aa)
SLC7A5SLC7A5 isoform 2. (507 aa)
SERPINA10SERPINA10 isoform 2; Belongs to the serpin family. (484 aa)
SRSF5Serine and arginine rich splicing factor 5. (272 aa)
LCP1Lymphocyte cytosolic protein 1. (627 aa)
CPB2Carboxypeptidase B2. (423 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (993 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
NNMTNicotinamide N-methyltransferase. (264 aa)
UCP2Uncoupling protein 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (309 aa)
ADMAdrenomedullin. (185 aa)
MKI67MKI67 isoform 1. (3257 aa)
UPF2UPF2 regulator of nonsense mediated mRNA decay. (1272 aa)
NR0B2Nuclear receptor subfamily 0 group B member 2. (257 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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