STRINGSTRING
APP APP PAPOLA PAPOLA LEO1 LEO1 NUDT21 NUDT21 CPSF4L CPSF4L ZNF473 ZNF473 CPSF3 CPSF3 PAPOLG PAPOLG WDR33 WDR33 POLR2D POLR2D RPRD1B RPRD1B PABPC1L PABPC1L CSTF1 CSTF1 GRSF1 GRSF1 LSM11 LSM11 CPSF4 CPSF4 ZC3H3 ZC3H3 TENT4B TENT4B RPRD2 RPRD2 TENT2 TENT2 MBLAC1 MBLAC1 MTPAP MTPAP APLP1 APLP1 FNDC10 FNDC10 NCBP1 NCBP1 CLP1 CLP1 CPSF1 CPSF1 SYMPK SYMPK AHCYL1 AHCYL1 CSTF2 CSTF2 ENSPTRP00000068740 ENSPTRP00000068740 PABPC1 PABPC1 ENSPTRP00000074297 ENSPTRP00000074297 CPSF1-2 CPSF1-2 SSU72P8 SSU72P8 CK820_G0008138 CK820_G0008138 NCBP2 NCBP2 PAF1 PAF1 CK820_G0020029 CK820_G0020029 CK820_G0053209 CK820_G0053209 PNPT1 PNPT1 TMEM240 TMEM240 RPRD1A RPRD1A SLBP SLBP CDC73 CDC73 FIP1L1 FIP1L1 ENSPTRP00000091616 ENSPTRP00000091616 SCAF8 SCAF8 PAPOLB PAPOLB ENSPTRP00000093260 ENSPTRP00000093260 SSU72 SSU72 LSM10 LSM10 CSTF3 CSTF3 CPSF7 CPSF7 TUT1 TUT1 PCF11 PCF11 CPSF6 CPSF6 CPSF2 CPSF2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
APPGamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (771 aa)
PAPOLAPoly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's. (745 aa)
LEO1Leo1, Paf1/RNA polymerase II complex component, homolog. (666 aa)
NUDT21Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...] (227 aa)
CPSF4LCleavage and polyadenylation specific factor 4 like. (179 aa)
ZNF473Zinc finger protein 473. (871 aa)
CPSF3Cleavage and polyadenylation specificity factor 73 kDa subunit. (684 aa)
PAPOLGPoly(A) polymerase gamma. (736 aa)
WDR33WD repeat domain 33. (1336 aa)
POLR2DPolymerase (RNA) II (DNA directed) polypeptide D. (142 aa)
RPRD1BRegulation of nuclear pre-mRNA domain containing 1B. (326 aa)
PABPC1LPoly(A) binding protein cytoplasmic 1 like. (330 aa)
CSTF1Cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa. (431 aa)
GRSF1G-rich RNA sequence binding factor 1. (481 aa)
LSM11LSM11, U7 small nuclear RNA associated. (338 aa)
CPSF4Cleavage and polyadenylation specific factor 4, 30kDa. (269 aa)
ZC3H3Zinc finger CCCH-type containing 3. (952 aa)
TENT4BTerminal nucleotidyltransferase 4B. (700 aa)
RPRD2Regulation of nuclear pre-mRNA domain containing 2. (1461 aa)
TENT2PAPD4 isoform 1. (484 aa)
MBLAC1Metallo-beta-lactamase domain containing 1. (266 aa)
MTPAPMitochondrial poly(A) polymerase. (582 aa)
APLP1APLP1 isoform 2. (650 aa)
FNDC10Fibronectin type III domain containing 10. (226 aa)
NCBP1Nuclear cap binding protein subunit 1, 80kDa. (790 aa)
CLP1Polyribonucleotide 5'-hydroxyl-kinase Clp1; Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; thi [...] (425 aa)
CPSF1CPSF1 isoform 10. (1467 aa)
SYMPKSYMPK isoform 3. (1310 aa)
AHCYL1Adenosylhomocysteinase. (499 aa)
CSTF2Cleavage stimulation factor subunit 2. (597 aa)
ENSPTRP00000068740annotation not available (675 aa)
PABPC1Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (636 aa)
ENSPTRP00000074297annotation not available (184 aa)
CPSF1-2Cleavage and polyadenylation specific factor 1, 160kDa. (1442 aa)
SSU72P8SSU72 pseudogene 8. (194 aa)
CK820_G0008138CSTF2T isoform 1. (302 aa)
NCBP2Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...] (148 aa)
PAF1Paf1, RNA polymerase II associated factor, homolog. (533 aa)
CK820_G0020029PABPC1L isoform 9. (171 aa)
CK820_G0053209T0188532 isoform 1. (194 aa)
PNPT1Polyribonucleotide nucleotidyltransferase 1. (784 aa)
TMEM240Chromosome 1 open reading frame 70. (173 aa)
RPRD1ARegulation of nuclear pre-mRNA domain containing 1A. (312 aa)
SLBPHistone RNA hairpin-binding protein. (272 aa)
CDC73Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog. (531 aa)
FIP1L1Pre-mRNA 3'-end-processing factor FIP1 isoform X1. (603 aa)
ENSPTRP00000091616annotation not available (183 aa)
SCAF8SR-related CTD associated factor 8. (1352 aa)
PAPOLBPoly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's. (687 aa)
ENSPTRP00000093260annotation not available (603 aa)
SSU72SSU72 RNA polymerase II CTD phosphatase homolog. (183 aa)
LSM10LSM10, U7 small nuclear RNA associated. (123 aa)
CSTF3Cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa. (717 aa)
CPSF7CPSF7 isoform 1. (471 aa)
TUT1Terminal uridylyl transferase 1, U6 snRNA-specific. (912 aa)
PCF11PCF11, cleavage and polyadenylation factor subunit, homolog. (1686 aa)
CPSF6CPSF6 isoform 3. (589 aa)
CPSF2Cleavage and polyadenylation specificity factor subunit 2. (782 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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