54 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	XBP1	XBP1 isoform 4. (381 aa)
	HTT	HTT isoform 1. (3131 aa)
	ENSPTRP00000064998	annotation not available (175 aa)
	FBXW9	F-box and WD repeat domain containing 9. (478 aa)
	LOC453361	CAPN3 isoform 4; Belongs to the peptidase C2 family. (821 aa)
	RNF5	Ring finger protein 5. (180 aa)
	ISOC1	Isochorismatase domain containing 1. (298 aa)
	UTP25	Digestive organ expansion factor homolog (Zebrafish). (756 aa)
	PRKDC	Protein kinase, DNA-activated, catalytic polypeptide; Belongs to the PI3/PI4-kinase family. (4128 aa)
	FBXL3	F-box and leucine-rich repeat protein 3. (428 aa)
	PEX2	Peroxisomal membrane protein 3, 35kDa. (305 aa)
	MYLIP	Myosin regulatory light chain interacting protein. (445 aa)
	HDAC6	Histone deacetylase 6. (146 aa)
	GSN	GSN isoform 3. (782 aa)
	RNF139	Ring finger protein 139. (664 aa)
	DERL1	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (251 aa)
	SOX17	SOX17 isoform 1. (416 aa)
	PRKN	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (465 aa)
	FBXO4	F-box protein 4. (387 aa)
	FBXW7	F-box and WD repeat domain containing 7. (707 aa)
	SENP2	SUMO1/sentrin/SMT3 specific peptidase 2. (589 aa)
	EP300	E1A binding protein p300. (2175 aa)
	BMP2	Bone morphogenetic protein 2. (398 aa)
	CUL3	CUL3 isoform 2; Belongs to the cullin family. (768 aa)
	ISOC2	Isochorismatase domain containing 2. (205 aa)
	RAD23A	RAD23 homolog A, nucleotide excision repair protein. (363 aa)
	SIRT6	SIRT6 isoform 1. (355 aa)
	NR1D1	Nuclear receptor subfamily 1, group D, member 1. (614 aa)
	VPS35	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (796 aa)
	KDM8	KDM8 isoform 5. (454 aa)
	CTSH	CTSH isoform 11; Belongs to the peptidase C1 family. (335 aa)
	SERF2	Small EDRK-rich factor 2. (170 aa)
	CCDC88C	CCDC88C isoform 3. (2028 aa)
	IAPP	Islet amyloid polypeptide. (89 aa)
	TRIM21	Tripartite motif containing 21. (475 aa)
	SIRT1-2	Sirtuin 1. (751 aa)
	PLK1	Serine/threonine-protein kinase PLK. (621 aa)
	SIRT1	SIRT1 isoform 2. (751 aa)
	PYHIN1	Pyrin and HIN domain family member 1. (483 aa)
	MUL1	Mitochondrial E3 ubiquitin protein ligase 1. (352 aa)
	ENSPTRP00000092749	annotation not available (128 aa)
	SNCA	Alpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] (140 aa)
	CDC73	Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog. (531 aa)
	LOC741943	SERF1B isoform 3. (86 aa)
	CHFR	Checkpoint with forkhead and ring finger domains. (664 aa)
	FBXW11	F-box and WD repeat domain containing 11. (563 aa)
	IRGM	Immunity-related GTPase M. (214 aa)
	BTRC	Beta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
	CDKN2A	Cyclin-dependent kinase inhibitor 2A (Melanoma, p16, inhibits CDK4). (173 aa)
	SRC	Tyrosine-protein kinase. (542 aa)
	PRNP	Major prion protein; Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan s [...] (253 aa)
	CREBBP	CREB binding protein. (2442 aa)
	ENSPTRP00000074041	annotation not available (223 aa)
	GGA3	Golgi-associated, gamma adaptin ear containing, ARF binding protein 3. (723 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP2	EP300	ENSPTRP00000022701	ENSPTRP00000024841	Bone morphogenetic protein 2.	E1A binding protein p300.	0.499
BTRC	CREBBP	ENSPTRP00000077054	ENSPTRP00000074980	Beta-transducin repeat containing E3 ubiquitin protein ligase.	CREB binding protein.	0.463
BTRC	CUL3	ENSPTRP00000077054	ENSPTRP00000022190	Beta-transducin repeat containing E3 ubiquitin protein ligase.	CUL3 isoform 2; Belongs to the cullin family.	0.889
BTRC	ENSPTRP00000074041	ENSPTRP00000077054	ENSPTRP00000074041	Beta-transducin repeat containing E3 ubiquitin protein ligase.	annotation not available	0.568
BTRC	EP300	ENSPTRP00000077054	ENSPTRP00000024841	Beta-transducin repeat containing E3 ubiquitin protein ligase.	E1A binding protein p300.	0.503
BTRC	FBXL3	ENSPTRP00000077054	ENSPTRP00000043543	Beta-transducin repeat containing E3 ubiquitin protein ligase.	F-box and leucine-rich repeat protein 3.	0.572
BTRC	FBXO4	ENSPTRP00000077054	ENSPTRP00000028852	Beta-transducin repeat containing E3 ubiquitin protein ligase.	F-box protein 4.	0.933
BTRC	FBXW11	ENSPTRP00000077054	ENSPTRP00000078073	Beta-transducin repeat containing E3 ubiquitin protein ligase.	F-box and WD repeat domain containing 11.	0.907
BTRC	FBXW7	ENSPTRP00000077054	ENSPTRP00000028353	Beta-transducin repeat containing E3 ubiquitin protein ligase.	F-box and WD repeat domain containing 7.	0.965
BTRC	PLK1	ENSPTRP00000077054	ENSPTRP00000093799	Beta-transducin repeat containing E3 ubiquitin protein ligase.	Serine/threonine-protein kinase PLK.	0.798
CHFR	DERL1	ENSPTRP00000085984	ENSPTRP00000035139	Checkpoint with forkhead and ring finger domains.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.666
CHFR	PLK1	ENSPTRP00000085984	ENSPTRP00000093799	Checkpoint with forkhead and ring finger domains.	Serine/threonine-protein kinase PLK.	0.593
CHFR	RAD23A	ENSPTRP00000085984	ENSPTRP00000018011	Checkpoint with forkhead and ring finger domains.	RAD23 homolog A, nucleotide excision repair protein.	0.461
CREBBP	BTRC	ENSPTRP00000074980	ENSPTRP00000077054	CREB binding protein.	Beta-transducin repeat containing E3 ubiquitin protein ligase.	0.463
CREBBP	EP300	ENSPTRP00000074980	ENSPTRP00000024841	CREB binding protein.	E1A binding protein p300.	0.999
CREBBP	FBXW7	ENSPTRP00000074980	ENSPTRP00000028353	CREB binding protein.	F-box and WD repeat domain containing 7.	0.473
CREBBP	HDAC6	ENSPTRP00000074980	ENSPTRP00000037550	CREB binding protein.	Histone deacetylase 6.	0.564
CREBBP	HTT	ENSPTRP00000074980	ENSPTRP00000065166	CREB binding protein.	HTT isoform 1.	0.966
CREBBP	SIRT1	ENSPTRP00000074980	ENSPTRP00000004394	CREB binding protein.	SIRT1 isoform 2.	0.565
CREBBP	SIRT1-2	ENSPTRP00000074980	ENSPTRP00000093057	CREB binding protein.	Sirtuin 1.	0.565