29 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	EFEMP1	EGF-containing fibulin-like extracellular matrix protein 1. (493 aa)
	ENSPTRP00000092364	annotation not available (574 aa)
	RARG	Retinoic acid receptor, gamma. (456 aa)
	RARB	Retinoic acid receptor, beta. (448 aa)
	BMP4-2	Bone morphogenetic protein 4. (408 aa)
	ENSPTRP00000077211	annotation not available (269 aa)
	ENSPTRP00000074763	annotation not available (520 aa)
	PTPN11-2	Protein tyrosine phosphatase non-receptor type 11. (579 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
	NKX3-2	NKX3-2 isoform 1. (333 aa)
	ENSPTRP00000067174	annotation not available (502 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
	ADAMTS12	ADAM metallopeptidase with thrombospondin type 1 motif 12. (1509 aa)
	RFLNA	RFLNA isoform 1. (216 aa)
	CHADL	Chondroadherin like. (762 aa)
	CTNNB1	Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
	PTHLH	PTHLH isoform 7. (209 aa)
	CCN4	WISP1 isoform 1. (367 aa)
	SNAI2	Snail family transcriptional repressor 2. (268 aa)
	GLI3	Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa)
	GDF5	GDF5 isoform 1. (501 aa)
	IHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
	SOX9	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
	RFLNB	RFLNB isoform 1. (144 aa)
	ADAMTS7	ADAMTS7 isoform 1. (932 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	LTBP3	Latent transforming growth factor beta binding protein 3. (1297 aa)
	PTH	Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa)
	WNT9A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	CTNNB1	ENSPTRP00000010780	ENSPTRP00000044466	Bone morphogenetic protein 4.	Catenin (Cadherin-associated protein), beta 1, 88kDa.	0.551
BMP4	IHH	ENSPTRP00000010780	ENSPTRP00000022106	Bone morphogenetic protein 4.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.421
BMP4	SOX9	ENSPTRP00000010780	ENSPTRP00000016293	Bone morphogenetic protein 4.	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219.	0.509
BMP4	TGFBR1	ENSPTRP00000010780	ENSPTRP00000073078	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.724
BMP4-2	CTNNB1	ENSPTRP00000080656	ENSPTRP00000044466	Bone morphogenetic protein 4.	Catenin (Cadherin-associated protein), beta 1, 88kDa.	0.551
BMP4-2	IHH	ENSPTRP00000080656	ENSPTRP00000022106	Bone morphogenetic protein 4.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.421
BMP4-2	SOX9	ENSPTRP00000080656	ENSPTRP00000016293	Bone morphogenetic protein 4.	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219.	0.509
BMP4-2	TGFBR1	ENSPTRP00000080656	ENSPTRP00000073078	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.724
CCN4	CTNNB1	ENSPTRP00000035228	ENSPTRP00000044466	WISP1 isoform 1.	Catenin (Cadherin-associated protein), beta 1, 88kDa.	0.463
CTNNB1	BMP4	ENSPTRP00000044466	ENSPTRP00000010780	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Bone morphogenetic protein 4.	0.551
CTNNB1	BMP4-2	ENSPTRP00000044466	ENSPTRP00000080656	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Bone morphogenetic protein 4.	0.551
CTNNB1	CCN4	ENSPTRP00000044466	ENSPTRP00000035228	Catenin (Cadherin-associated protein), beta 1, 88kDa.	WISP1 isoform 1.	0.463
CTNNB1	ENSPTRP00000067174	ENSPTRP00000044466	ENSPTRP00000067174	Catenin (Cadherin-associated protein), beta 1, 88kDa.	annotation not available	0.578
CTNNB1	ENSPTRP00000074763	ENSPTRP00000044466	ENSPTRP00000074763	Catenin (Cadherin-associated protein), beta 1, 88kDa.	annotation not available	0.504
CTNNB1	ENSPTRP00000077211	ENSPTRP00000044466	ENSPTRP00000077211	Catenin (Cadherin-associated protein), beta 1, 88kDa.	annotation not available	0.504
CTNNB1	ENSPTRP00000092364	ENSPTRP00000044466	ENSPTRP00000092364	Catenin (Cadherin-associated protein), beta 1, 88kDa.	annotation not available	0.504
CTNNB1	GLI3	ENSPTRP00000044466	ENSPTRP00000032656	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...]	0.520
CTNNB1	IHH	ENSPTRP00000044466	ENSPTRP00000022106	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.461
CTNNB1	PTH	ENSPTRP00000044466	ENSPTRP00000005898	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family.	0.461
CTNNB1	PTPN11	ENSPTRP00000044466	ENSPTRP00000061336	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.578