STRINGSTRING
H2AFV H2AFV ESR1 ESR1 SLC34A1 SLC34A1 CRHBP CRHBP MAP1B MAP1B HPGD HPGD SRD5A1 SRD5A1 POU4F2 POU4F2 CCNA2 CCNA2 TACR3 TACR3 H2AZ1 H2AZ1 HNRNPD HNRNPD CSN1S1 CSN1S1 CD38 CD38 GHSR GHSR SLC6A1 SLC6A1 OGG1 OGG1 OXTR OXTR BMP7 BMP7 FAM210B FAM210B NCOA3 NCOA3 PCNA PCNA OXT OXT IHH IHH IGFBP2 IGFBP2 CASP8 CASP8 TACR1 TACR1 CYP1B1 CYP1B1 UCN UCN TGFB1 TGFB1 CALR CALR MBD3L1 MBD3L1 COL1A1 COL1A1 SLC6A4 SLC6A4 NQO1 NQO1 MMP15 MMP15 LOC101056957 LOC101056957 IGF1R IGF1R ALDH1A2 ALDH1A2 CYP19A1 CYP19A1 ESR2 ESR2 CCDC62 CCDC62 SOCS2 SOCS2 CDKN1B CDKN1B CRYAB CRYAB KAT5 KAT5 ESRRA ESRRA CAT CAT MYOD1 MYOD1 TH TH WNT8B WNT8B LCOR LCOR PTGS2 PTGS2 TXNIP TXNIP POU4F1 POU4F1 BAD BAD ENSPTRP00000092628 ENSPTRP00000092628 STAT3 STAT3 ENSPTRP00000090987 ENSPTRP00000090987 EZH2-2 EZH2-2 CCN2 CCN2 CASP9 CASP9 GPI GPI STAT5B STAT5B NCOR2 NCOR2 ENSPTRP00000088102 ENSPTRP00000088102 MMP2 MMP2 HSF1 HSF1 PTCH1 PTCH1 STXBP1 STXBP1 CCND1 CCND1 CK820_G0031483 CK820_G0031483 FGF10 FGF10 ITGA2 ITGA2 SSTR2 SSTR2 NRIP1 NRIP1 PDGFRB PDGFRB LOC100612565 LOC100612565 NR2F2 NR2F2 CFLAR CFLAR LOC107971060 LOC107971060 ADCYAP1R1-2 ADCYAP1R1-2 EZH2 EZH2 ENSPTRP00000077036 ENSPTRP00000077036 ENSPTRP00000076749 ENSPTRP00000076749 BCL2L11 BCL2L11 DHH DHH ADCYAP1R1 ADCYAP1R1 GHR GHR PPP1R9B PPP1R9B ENSPTRP00000073414 ENSPTRP00000073414 HTR5A-2 HTR5A-2 ENSPTRP00000071015 ENSPTRP00000071015 LOC100609621 LOC100609621 LOC461877 LOC461877 AIFM1 AIFM1 EGFR EGFR H2AFV-2 H2AFV-2 SSTR3 SSTR3 SSTR1 SSTR1 ENO2 ENO2 ENSPTRP00000065421 ENSPTRP00000065421 KIF18A KIF18A RUVBL2 RUVBL2 FOXA1 FOXA1 ENSPTRP00000062077 ENSPTRP00000062077 ENSPTRP00000062039 ENSPTRP00000062039 AREG AREG DNMT3A DNMT3A SFRP1 SFRP1 RARA RARA PTGFR PTGFR APOB APOB MBD2 MBD2 ANXA1 ANXA1 GPX4 GPX4 ENDOG ENDOG PAM PAM MBD3 MBD3 CTNNB1 CTNNB1 MYOG MYOG STRN3 STRN3 ASS1 ASS1 PENK PENK ZNF703 ZNF703 HTR5A HTR5A RAMP3 RAMP3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
H2AFVH2AFV isoform 6. (128 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
SLC34A1SLC34A1 isoform 1. (626 aa)
CRHBPCorticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (322 aa)
MAP1BMicrotubule associated protein 1B. (2468 aa)
HPGD15-hydroxyprostaglandin dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (266 aa)
SRD5A13-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (259 aa)
POU4F2POU domain protein. (406 aa)
CCNA2CCNA2 isoform 1; Belongs to the cyclin family. (432 aa)
TACR3Tachykinin receptor 3; Belongs to the G-protein coupled receptor 1 family. (465 aa)
H2AZ1H2AFZ isoform 3. (128 aa)
HNRNPDHNRNPD isoform 1. (356 aa)
CSN1S1CSN1S1 isoform 1. (185 aa)
CD38CD38 isoform 1. (300 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
SLC6A1Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (599 aa)
OGG18-oxoguanine DNA glycosylase. (424 aa)
OXTROxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (389 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
FAM210BFAM210B isoform 1. (192 aa)
NCOA3Nuclear receptor coactivator. (1426 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
OXTOxytocin/neurophysin I prepropeptide; Belongs to the vasopressin/oxytocin family. (125 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
IGFBP2Insulin-like growth factor binding protein 2, 36kDa. (325 aa)
CASP8Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (538 aa)
TACR1Tachykinin receptor 1; Belongs to the G-protein coupled receptor 1 family. (407 aa)
CYP1B1Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (543 aa)
UCNUCN isoform 1. (124 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
CALRCalreticulin. (414 aa)
MBD3L1Methyl-CpG binding domain protein 3 like 1. (194 aa)
COL1A1Collagen type I alpha 1 chain. (1464 aa)
SLC6A4Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (630 aa)
NQO1NAD(P)H quinone dehydrogenase 1. (274 aa)
MMP15Matrix metallopeptidase 15. (669 aa)
LOC101056957T0109256 isoform 1. (3229 aa)
IGF1RTyrosine-protein kinase receptor. (1364 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
CYP19A1Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family. (503 aa)
ESR2Estrogen receptor 2. (530 aa)
CCDC62Coiled-coil domain containing 62. (683 aa)
SOCS2Suppressor of cytokine signaling 2. (198 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B (P27, Kip1). (198 aa)
CRYABCrystallin alpha B; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (175 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (513 aa)
ESRRAEstrogen-related receptor alpha. (422 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
MYOD1Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (320 aa)
THTyrosine hydroxylase. (528 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
LCORLigand dependent nuclear receptor corepressor. (1556 aa)
PTGS2Prostaglandin-endoperoxide synthase 2 (Prostaglandin G/H synthase and cyclooxygenase). (604 aa)
TXNIPArrestin_C domain-containing protein. (391 aa)
POU4F1POU domain protein. (350 aa)
BADBcl2-associated agonist of cell death. (168 aa)
ENSPTRP00000092628annotation not available (129 aa)
STAT3Signal transducer and activator of transcription. (790 aa)
ENSPTRP00000090987annotation not available (87 aa)
EZH2-2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (751 aa)
CCN2CTGF isoform 1. (349 aa)
CASP9CASP9 isoform 4; Belongs to the peptidase C14A family. (421 aa)
GPIGlucose-6-phosphate isomerase; Belongs to the GPI family. (597 aa)
STAT5BSignal transducer and activator of transcription. (772 aa)
NCOR2Nuclear receptor corepressor 2. (2514 aa)
ENSPTRP00000088102annotation not available (203 aa)
MMP2Matrix metallopeptidase 2. (660 aa)
HSF1Heat shock transcription factor 1. (529 aa)
PTCH1PTCH1 isoform 8. (1428 aa)
STXBP1Syntaxin binding protein 1; Belongs to the STXBP/unc-18/SEC1 family. (603 aa)
CCND1CCND1 isoform 1; Belongs to the cyclin family. (295 aa)
CK820_G0031483H2AFV isoform 8. (118 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ITGA2Integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); Belongs to the integrin alpha chain family. (1183 aa)
SSTR2Somatostatin receptor type 2; Belongs to the G-protein coupled receptor 1 family. (369 aa)
NRIP1Nuclear receptor interacting protein 1. (1158 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
LOC100612565Steroid hormone receptor ERR1 pseudogene. (396 aa)
NR2F2Nuclear receptor subfamily 2, group F, member 2. (414 aa)
CFLARCASP8 and FADD-like apoptosis regulator; Belongs to the peptidase C14A family. (480 aa)
LOC107971060SRD5A1 isoform 2. (141 aa)
ADCYAP1R1-2ADCYAP receptor type I; Belongs to the G-protein coupled receptor 2 family. (517 aa)
EZH2Enhancer of zeste homolog 2. (754 aa)
ENSPTRP00000077036annotation not available (396 aa)
ENSPTRP00000076749annotation not available (243 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
DHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (396 aa)
ADCYAP1R1ADCYAP receptor type I; Belongs to the G-protein coupled receptor 2 family. (524 aa)
GHRGrowth hormone receptor. (645 aa)
PPP1R9BProtein phosphatase 1, regulatory (Inhibitor) subunit 9B. (817 aa)
ENSPTRP00000073414annotation not available (393 aa)
HTR5A-25-hydroxytryptamine receptor 5A. (357 aa)
ENSPTRP00000071015annotation not available (408 aa)
LOC100609621Argininosuccinate synthase pseudogene. (245 aa)
LOC461877Argininosuccinate synthase pseudogene. (389 aa)
AIFM1Apoptosis-inducing factor, mitochondrion-associated, 1. (603 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
H2AFV-2H2A histone family member V. (127 aa)
SSTR3Somatostatin receptor 3; Belongs to the G-protein coupled receptor 1 family. (418 aa)
SSTR1Somatostatin receptor 1; Belongs to the G-protein coupled receptor 1 family. (391 aa)
ENO2Enolase 2 (Gamma, neuronal). (434 aa)
ENSPTRP00000065421annotation not available (120 aa)
KIF18AKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (898 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa)
FOXA1FOXA1 isoform 1. (471 aa)
ENSPTRP00000062077annotation not available (236 aa)
ENSPTRP00000062039annotation not available (397 aa)
AREGAREG isoform 2. (274 aa)
DNMT3ADNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (912 aa)
SFRP1Secreted frizzled-related protein 1. (314 aa)
RARARARA isoform 4. (624 aa)
PTGFRProstaglandin F receptor (FP); Belongs to the G-protein coupled receptor 1 family. (359 aa)
APOBAPOB isoform 1. (4562 aa)
MBD2MBD2 isoform 1. (382 aa)
ANXA1Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of Fthe formyl peptide receptors (By similarity). Contribu [...] (346 aa)
GPX4Glutathione peroxidase; Belongs to the glutathione peroxidase family. (233 aa)
ENDOGEndonuclease. (297 aa)
PAMPeptidylglycine alpha-amidating monooxygenase. (973 aa)
MBD3Methyl-CpG binding domain protein 3. (291 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
MYOGMYOG isoform 1. (249 aa)
STRN3Striatin, calmodulin binding protein 3. (797 aa)
ASS1Argininosuccinate synthetase 1. (412 aa)
PENKPENK isoform 3. (267 aa)
ZNF703Zinc finger protein 703. (590 aa)
HTR5A5-hydroxytryptamine receptor 5A. (357 aa)
RAMP3Receptor activity modifying protein 3. (151 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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