STRINGSTRING
ARHGEF2 ARHGEF2 ENSPTRP00000071392 ENSPTRP00000071392 LOC104003887 LOC104003887 PTPN22 PTPN22 IRF5 IRF5 TRIM41 TRIM41 CARD9 CARD9 ENSPTRP00000069712 ENSPTRP00000069712 INAVA INAVA VIM VIM NFKBIA NFKBIA NOD2 NOD2 NLRP1 NLRP1 JAG1 JAG1 RIPK2 RIPK2 ERBIN ERBIN RELA RELA NOTCH1 NOTCH1 CHMP5 CHMP5 NOD1 NOD1 TNFAIP3 TNFAIP3 MAPK14 MAPK14
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (1031 aa)
ENSPTRP00000071392annotation not available (233 aa)
LOC104003887Charged multivesicular body protein 5 pseudogene. (198 aa)
PTPN22Protein tyrosine phosphatase, non-receptor type 22 (Lymphoid). (807 aa)
IRF5Interferon regulatory factor 5. (515 aa)
TRIM41Tripartite motif containing 41. (632 aa)
CARD9Caspase recruitment domain family, member 9. (536 aa)
ENSPTRP00000069712annotation not available (201 aa)
INAVAINAVA isoform 1. (663 aa)
VIMVimentin; Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. (466 aa)
NFKBIANuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha. (317 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2; Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3, INAVA and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macroph [...] (1040 aa)
NLRP1NLR family, pyrin domain containing 1. (1471 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (551 aa)
ERBINErbb2 interacting protein. (1419 aa)
RELAV-rel reticuloendotheliosis viral oncogene homolog A (Avian). (551 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
CHMP5Charged multivesicular body protein 5. (219 aa)
NOD1Nucleotide-binding oligomerization domain containing 1. (953 aa)
TNFAIP3Tumor necrosis factor, alpha-induced protein 3. (790 aa)
MAPK14Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] (360 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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