STRINGSTRING
CD34 CD34 NID1 NID1 EDNRB EDNRB BMP4 BMP4 MYO1E MYO1E IQGAP1 IQGAP1 NPHS2 NPHS2 FOXJ1 FOXJ1 NOTCH3 NOTCH3 OSR1 OSR1 MPV17 MPV17 COL4A3 COL4A3 JAG1 JAG1 PDGFB PDGFB LAMB2 LAMB2 PROM1 PROM1 EDNRA EDNRA TCF21 TCF21 AQP1 AQP1 MAGI2 MAGI2 ANGPT2 ANGPT2 EXT1 EXT1 NOTCH1 NOTCH1 WWTR1 WWTR1 COL4A4 COL4A4 FOXC2 FOXC2 PLCE1 PLCE1 NPHS1 NPHS1 ENPEP ENPEP HES1 HES1 KLF15 KLF15 FOXC1 FOXC1 BASP1 BASP1 TEK TEK ASXL1 ASXL1 PODXL PODXL SULF1 SULF1 NOTCH2 NOTCH2 PTPRO PTPRO GPR4 GPR4 PDGFRB PDGFRB LOC107968591 LOC107968591 BMP4-2 BMP4-2 PECAM1 PECAM1 SULF2 SULF2 CD24 CD24 KIRREL3 KIRREL3 MTSS1 MTSS1 EGR1 EGR1 WT1 WT1 HEYL HEYL BCL2 BCL2 MEF2C MEF2C ANGPT1 ANGPT1 LGR4 LGR4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CD34CD34 isoform 1. (328 aa)
NID1NID1 isoform 2. (1247 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (532 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
MYO1EMYO1E isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1108 aa)
IQGAP1IQ motif containing GTPase activating protein 1. (1657 aa)
NPHS2NPHS2 stomatin family member, podocin. (383 aa)
FOXJ1FOXJ1 isoform 1. (421 aa)
NOTCH3NOTCH3 isoform 1. (2321 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
MPV17Mitochondrial inner membrane protein MPV17; Belongs to the peroxisomal membrane protein PXMP2/4 family. (176 aa)
COL4A3Collagen type IV alpha 3 chain. (1670 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
LAMB2Laminin, beta 2 (Laminin S). (1798 aa)
PROM1PROM1 isoform 12. (865 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
TCF21Transcription factor 21. (179 aa)
AQP1Aquaporin-1 isoform X2. (269 aa)
MAGI2Membrane associated guanylate kinase, WW and PDZ domain containing 2. (1283 aa)
ANGPT2ANGPT2 isoform 1. (496 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
WWTR1WW domain containing transcription regulator 1. (400 aa)
COL4A4COL4A4 isoform 1. (1690 aa)
FOXC2Forkhead box C2 (MFH-1, mesenchyme forkhead 1). (501 aa)
PLCE1Phosphoinositide phospholipase C. (2301 aa)
NPHS1NPHS1 isoform 1. (1241 aa)
ENPEPAminopeptidase. (979 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
KLF15Kruppel-like factor 15. (416 aa)
FOXC1FOXC1 isoform 1. (550 aa)
BASP1Brain abundant, membrane attached signal protein 1. (226 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
ASXL1ASXL transcriptional regulator 1. (1548 aa)
PODXLPodocalyxin; Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Belongs to the podocalyxin family. (556 aa)
SULF1Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (901 aa)
NOTCH2NOTCH2 isoform 1. (2612 aa)
PTPROProtein tyrosine phosphatase receptor type O. (1216 aa)
GPR4G protein-coupled receptor 4; Belongs to the G-protein coupled receptor 1 family. (362 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
LOC107968591CD24 isoform 1. (80 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
PECAM1Platelet/endothelial cell adhesion molecule. (745 aa)
SULF2Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (870 aa)
CD24CD24 isoform 8. (129 aa)
KIRREL3Kirre like nephrin family adhesion molecule 3. (787 aa)
MTSS1MTSS I-BAR domain containing 1. (759 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa)
WT1WT1 transcription factor. (514 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (328 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
ANGPT1ANGPT1 isoform 2. (498 aa)
LGR4LGR4 isoform 2. (951 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: medium (42%) [HD]