STRINGSTRING
NODAL NODAL ACVRL1 ACVRL1 ACVR1B ACVR1B AMHR2 AMHR2 FGF9 FGF9 SMAD4 SMAD4 ACVR2A ACVR2A ACVR1C ACVR1C TGIF2 TGIF2 TDGF1 TDGF1 FOXH1 FOXH1 BMPR2 BMPR2 FOXH1-2 FOXH1-2 SMAD2 SMAD2 GDF2 GDF2 TGFBR1 TGFBR1 TGFBR2 TGFBR2 ACVR1 ACVR1 GDF6 GDF6 ENSPTRP00000076822 ENSPTRP00000076822 ACVR2B ACVR2B BMP10 BMP10 ENSPTRP00000079019 ENSPTRP00000079019 CITED2 CITED2 HJV HJV ENSPTRP00000088702 ENSPTRP00000088702 SMAD3 SMAD3 INHBB INHBB LOC459608 LOC459608 INHBA INHBA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NODALNODAL isoform 2. (347 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (546 aa)
AMHR2Anti-Muellerian hormone type-2 receptor; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone. (573 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (493 aa)
TGIF2Homeobox protein TGIF2. (237 aa)
TDGF1Growth factor; Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family. (188 aa)
FOXH1FOXH1 isoform 1. (365 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (891 aa)
FOXH1-2Forkhead box H1. (365 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
GDF2GDF2 isoform 1. (429 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (581 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
GDF6Growth differentiation factor 6. (455 aa)
ENSPTRP00000076822annotation not available (142 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (512 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
ENSPTRP00000079019annotation not available (165 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
HJVHFE2 isoform 1. (426 aa)
ENSPTRP00000088702annotation not available (170 aa)
SMAD3Mothers against decapentaplegic homolog. (442 aa)
INHBBInhibin subunit beta B. (407 aa)
LOC459608CFC1B isoform 2. (223 aa)
INHBAInhibin subunit beta A. (426 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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