13 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	IHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
	IL1A	Interleukin-1; Belongs to the IL-1 family. (271 aa)
	CLEC4G	C-type lectin domain family 4 member G. (293 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	BMP4-2	Bone morphogenetic protein 4. (408 aa)
	TNFRSF9	TNF receptor superfamily member 9. (255 aa)
	CDKN2A	Cyclin-dependent kinase inhibitor 2A (Melanoma, p16, inhibits CDK4). (173 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
	ERBB2	Receptor protein-tyrosine kinase. (1255 aa)
	RIPK2	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (551 aa)
	FOXP3	FOXP3 isoform 4. (456 aa)
	TMEM131L	TMEM131L isoform 3. (1617 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	IHH	ENSPTRP00000010780	ENSPTRP00000022106	Bone morphogenetic protein 4.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.421
BMP4	SHH	ENSPTRP00000010780	ENSPTRP00000075730	Bone morphogenetic protein 4.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.720
BMP4-2	IHH	ENSPTRP00000080656	ENSPTRP00000022106	Bone morphogenetic protein 4.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.421
BMP4-2	SHH	ENSPTRP00000080656	ENSPTRP00000075730	Bone morphogenetic protein 4.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.720
ERBB2	FOXP3	ENSPTRP00000069840	ENSPTRP00000037587	Receptor protein-tyrosine kinase.	FOXP3 isoform 4.	0.457
ERBB2	RIPK2	ENSPTRP00000069840	ENSPTRP00000069317	Receptor protein-tyrosine kinase.	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.	0.408
ERBB2	SHH	ENSPTRP00000069840	ENSPTRP00000075730	Receptor protein-tyrosine kinase.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.469
ERBB2	TNFRSF9	ENSPTRP00000069840	ENSPTRP00000092872	Receptor protein-tyrosine kinase.	TNF receptor superfamily member 9.	0.581
FOXP3	ERBB2	ENSPTRP00000037587	ENSPTRP00000069840	FOXP3 isoform 4.	Receptor protein-tyrosine kinase.	0.457
FOXP3	IL1A	ENSPTRP00000037587	ENSPTRP00000021189	FOXP3 isoform 4.	Interleukin-1; Belongs to the IL-1 family.	0.502
FOXP3	IL1B	ENSPTRP00000037587	ENSPTRP00000021191	FOXP3 isoform 4.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.662
FOXP3	TNFRSF9	ENSPTRP00000037587	ENSPTRP00000092872	FOXP3 isoform 4.	TNF receptor superfamily member 9.	0.509
IHH	BMP4	ENSPTRP00000022106	ENSPTRP00000010780	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Bone morphogenetic protein 4.	0.421
IHH	BMP4-2	ENSPTRP00000022106	ENSPTRP00000080656	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Bone morphogenetic protein 4.	0.421
IHH	SHH	ENSPTRP00000022106	ENSPTRP00000075730	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.951
IL1A	FOXP3	ENSPTRP00000021189	ENSPTRP00000037587	Interleukin-1; Belongs to the IL-1 family.	FOXP3 isoform 4.	0.502
IL1A	IL1B	ENSPTRP00000021189	ENSPTRP00000021191	Interleukin-1; Belongs to the IL-1 family.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.998
IL1A	RIPK2	ENSPTRP00000021189	ENSPTRP00000069317	Interleukin-1; Belongs to the IL-1 family.	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.	0.486
IL1B	FOXP3	ENSPTRP00000021191	ENSPTRP00000037587	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	FOXP3 isoform 4.	0.662
IL1B	IL1A	ENSPTRP00000021191	ENSPTRP00000021189	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	Interleukin-1; Belongs to the IL-1 family.	0.998