STRINGSTRING
PINK1 PINK1 MAD2L2 MAD2L2 OPRD1 OPRD1 HAX1 HAX1 PTGS2 PTGS2 SMYD3 SMYD3 RET RET ERCC6 ERCC6 STOX1 STOX1 PAK1 PAK1 IAPP IAPP RAPGEF3 RAPGEF3 TBK1 TBK1 IFNG IFNG SPRY2 SPRY2 PRKD1 PRKD1 TCL1A TCL1A TERF2IP TERF2IP ARRB2 ARRB2 RPTOR RPTOR SH2D3A SH2D3A TGFB1 TGFB1 GSK3A GSK3A PRKD2 PRKD2 NTF4 NTF4 IL11 IL11 UCN UCN AVP AVP LIF LIF OSM OSM HCLS1 HCLS1 PFN2 PFN2 PDCD10 PDCD10 EIF4G1 EIF4G1 SFRP2 SFRP2 HSP90AB1 HSP90AB1 LATS1 LATS1 RAMP3 RAMP3 CAV1 CAV1 BAG4 BAG4 IFNB1 IFNB1 IFNA21 IFNA21 IFNA5 IFNA5 IFNE IFNE IFNK IFNK TXN TXN MAPKAP1 MAPKAP1 SH2D3C SH2D3C HDAC6 HDAC6 TENM1 TENM1 CSF3 CSF3 AXIN1 AXIN1 TNKS1BP1 TNKS1BP1 TFRC TFRC AKAP9 AKAP9 GCG GCG WNT3A WNT3A MTCP1 MTCP1 BDNF BDNF IFNA6 IFNA6 ENSPTRP00000062048 ENSPTRP00000062048 CNOT9 CNOT9 STK4 STK4 AKAP9-2 AKAP9-2 FNIP1 FNIP1 IL6 IL6 IFNA17 IFNA17 RIPK2 RIPK2 ATP2B4 ATP2B4 EGFR EGFR TNF TNF TCL1B TCL1B NGF NGF ENSPTRP00000070902 ENSPTRP00000070902 IFNA14 IFNA14 DOCK7 DOCK7 NRXN1 NRXN1 CALCR CALCR CREBL2 CREBL2 IRGM IRGM NTRK2 NTRK2 LOC472932 LOC472932 PARK7 PARK7 BRAF BRAF IL6-2 IL6-2 CK820_G0014527 CK820_G0014527 AKT1 AKT1 FNIP2 FNIP2 BCAR3 BCAR3 ARAF ARAF IFNA8 IFNA8 PIK3CA PIK3CA LOC741747 LOC741747 ENSPTRP00000085116 ENSPTRP00000085116 NTRK3 NTRK3 CAMK1 CAMK1 WNT5A WNT5A RAF1 RAF1 BRAF-2 BRAF-2 CAPRIN2 CAPRIN2 LOC742651 LOC742651 NTF3 NTF3 BCL2 BCL2 ENSPTRP00000090382 ENSPTRP00000090382 MIF MIF CD44 CD44 SNCA SNCA ANGPT1 ANGPT1 NOS1 NOS1 IFNW1 IFNW1 APP APP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PINK1PTEN induced putative kinase 1. (581 aa)
MAD2L2MAD2 mitotic arrest deficient-like 2. (211 aa)
OPRD1Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. (372 aa)
HAX1HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (279 aa)
PTGS2Prostaglandin-endoperoxide synthase 2 (Prostaglandin G/H synthase and cyclooxygenase). (604 aa)
SMYD3SET and MYND domain containing 3. (428 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1116 aa)
ERCC6ERCC6 isoform 1. (1491 aa)
STOX1STOX1 isoform 1. (887 aa)
PAK1Non-specific serine/threonine protein kinase. (553 aa)
IAPPIslet amyloid polypeptide. (89 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (923 aa)
TBK1TANK-binding kinase 1. (729 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). (166 aa)
SPRY2Sprouty homolog 2. (338 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (873 aa)
TCL1AT cell leukemia/lymphoma 1A. (114 aa)
TERF2IPTelomeric repeat binding factor 2, interacting protein. (399 aa)
ARRB2ARRB2 isoform 2. (430 aa)
RPTORRegulatory associated protein of MTOR, complex 1. (1324 aa)
SH2D3ASH2 domain containing 3A. (576 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
GSK3AGlycogen synthase kinase 3 alpha. (483 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa)
NTF4NTF4 isoform 1; Belongs to the NGF-beta family. (210 aa)
IL11IL11 isoform 1. (199 aa)
UCNUCN isoform 1. (124 aa)
AVPArginine vasopressin; Belongs to the vasopressin/oxytocin family. (164 aa)
LIFLeukemia inhibitory factor (Cholinergic differentiation factor). (202 aa)
OSMOSM isoform 1. (252 aa)
HCLS1Hematopoietic cell-specific Lyn substrate 1. (484 aa)
PFN2Profilin; Belongs to the profilin family. (188 aa)
PDCD10Programmed cell death 10. (212 aa)
EIF4G1Eukaryotic translation initiation factor 4 gamma 1. (1559 aa)
SFRP2Secreted frizzled-related protein 2. (295 aa)
HSP90AB1HSP90AB1 isoform 1. (688 aa)
LATS1LATS, large tumor suppressor, homolog 1. (1130 aa)
RAMP3Receptor activity modifying protein 3. (151 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
BAG4BCL2-associated athanogene 4. (457 aa)
IFNB1Interferon beta 1. (187 aa)
IFNA21Interferon alpha 21. (189 aa)
IFNA5Interferon alpha 5. (189 aa)
IFNEInterferon, epsilon. (208 aa)
IFNKIFNK isoform 1. (208 aa)
TXNThioredoxin; Belongs to the thioredoxin family. (105 aa)
MAPKAP1Mitogen-activated protein kinase associated protein 1. (522 aa)
SH2D3CSH2 domain containing 3C. (860 aa)
HDAC6Histone deacetylase 6. (146 aa)
TENM1Teneurin transmembrane protein 1. (2732 aa)
CSF3Colony stimulating factor 3 (Granulocyte). (204 aa)
AXIN1AXIN1 isoform 2. (859 aa)
TNKS1BP1Tankyrase 1 binding protein 1. (1729 aa)
TFRCTransferrin receptor (P90, CD71). (760 aa)
AKAP9A kinase (PRKA) anchor protein (Yotiao) 9. (3908 aa)
GCGGCG isoform 1. (180 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
MTCP1Mature T cell proliferation 1. (107 aa)
BDNFBrain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (329 aa)
IFNA6Interferon alpha 6. (190 aa)
ENSPTRP00000062048annotation not available (257 aa)
CNOT9CCR4-NOT transcription complex subunit 9. (331 aa)
STK4Serine/threonine-protein kinase 4. (487 aa)
AKAP9-2A-kinase anchoring protein 9. (3896 aa)
FNIP1Folliculin-interacting protein 1 isoform X1. (1166 aa)
IL6Interleukin 6 (Interferon, beta 2). (234 aa)
IFNA17IFNA17 isoform 1. (189 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (551 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1205 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
TCL1BT cell leukemia/lymphoma 1B. (128 aa)
NGFBeta-nerve growth factor; Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (By similarity). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone colla [...] (123 aa)
ENSPTRP00000070902annotation not available (168 aa)
IFNA14Interferon alpha 14. (189 aa)
DOCK7Dedicator of cytokinesis 7; Belongs to the DOCK family. (2129 aa)
NRXN1NRXN1 isoform 9. (1547 aa)
CALCRCalcitonin receptor; Belongs to the G-protein coupled receptor 2 family. (509 aa)
CREBL2cAMP-responsive element-binding protein-like 2. (193 aa)
IRGMImmunity-related GTPase M. (214 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
LOC472932BCL2 associated athanogene 4 pseudogene. (356 aa)
PARK7PARK7 isoform 1. (189 aa)
BRAFBRAF isoform 1; Belongs to the protein kinase superfamily. (767 aa)
IL6-2Interleukin 6. (234 aa)
CK820_G0014527IFNA13 isoform 2. (198 aa)
AKT1AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa)
FNIP2Folliculin interacting protein 2. (1167 aa)
BCAR3Breast cancer anti-estrogen resistance 3. (825 aa)
ARAFV-raf murine sarcoma 3611 viral oncogene homolog. (606 aa)
IFNA8Interferon alpha 8. (189 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1034 aa)
LOC741747IFNA7 isoform 1. (189 aa)
ENSPTRP00000085116annotation not available (227 aa)
NTRK3NT-3 growth factor receptor; Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation. (864 aa)
CAMK1Calcium/calmodulin-dependent protein kinase I; Belongs to the protein kinase superfamily. (380 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
RAF1RAF1 isoform 2; Belongs to the protein kinase superfamily. (668 aa)
BRAF-2BRAF isoform 2. (766 aa)
CAPRIN2Caprin family member 2. (1077 aa)
LOC742651IFNA1 isoform 1. (195 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (275 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
ENSPTRP00000090382annotation not available (493 aa)
MIFMacrophage migration inhibitory factor. (115 aa)
CD44CD44 isoform 3. (742 aa)
SNCAAlpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] (140 aa)
ANGPT1ANGPT1 isoform 2. (498 aa)
NOS1Nitric oxide synthase 1. (1468 aa)
IFNW1IFNW1 isoform 1. (200 aa)
APPGamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (771 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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