28 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Others

textmining

co-expression

protein homology

Your Input:
	CCN1	CCN family member 1; Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5 (By similarity). CCN1-mediated gene regulation is dependent on heparin-binding (By similarity). Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1 (By similarity). Promotes cell adhesion and adhesive s [...] (381 aa)
	TNN	TNN isoform 1. (1299 aa)
	FGFR2	Fibroblast growth factor receptor. (841 aa)
	NELL1	Neural EGFL like 1. (838 aa)
	IGF1R	Tyrosine-protein kinase receptor. (1364 aa)
	SOX8	SOX8 isoform 1. (446 aa)
	AXIN2	AXIN2 isoform 1. (843 aa)
	ATRAID	All-trans retinoic acid induced differentiation factor. (284 aa)
	BMP2	Bone morphogenetic protein 2. (398 aa)
	LTF	Lactotransferrin; Belongs to the transferrin family. (711 aa)
	PLXNB1	PLXNB1 isoform 1. (2135 aa)
	RHOA	Ras homolog family member A. (193 aa)
	HPSE	HPSE isoform 1. (592 aa)
	CTHRC1	Collagen triple helix repeat containing 1. (243 aa)
	ITGAV	Integrin, alpha V (Vitronectin receptor, alpha polypeptide, antigen CD51); Belongs to the integrin alpha chain family. (1048 aa)
	SFRP1	Secreted frizzled-related protein 1. (314 aa)
	CK820_G0012168	ABL1 isoform 3. (1149 aa)
	EIF2AK2	Eukaryotic translation initiation factor 2-alpha kinase 2. (552 aa)
	ITGB3	Integrin beta-3 isoform X2. (837 aa)
	NPR3	Natriuretic peptide receptor 3. (541 aa)
	LRP5	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1606 aa)
	TMEM119	Transmembrane protein 119. (283 aa)
	NF2	Neurofibromin 2 (Merlin). (595 aa)
	ABL1	Tyrosine-protein kinase. (1149 aa)
	MN1	MN1 proto-oncogene, transcriptional regulator. (1325 aa)
	GATA1	GATA binding protein 1. (413 aa)
	BCL2	BCL2 apoptosis regulator. (239 aa)
	SMAD3	Mothers against decapentaplegic homolog. (442 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	BCL2	ENSPTRP00000072918	ENSPTRP00000090293	Tyrosine-protein kinase.	BCL2 apoptosis regulator.	0.497
ABL1	RHOA	ENSPTRP00000072918	ENSPTRP00000025759	Tyrosine-protein kinase.	Ras homolog family member A.	0.407
AXIN2	LRP5	ENSPTRP00000016228	ENSPTRP00000068813	AXIN2 isoform 1.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.823
AXIN2	SFRP1	ENSPTRP00000016228	ENSPTRP00000053182	AXIN2 isoform 1.	Secreted frizzled-related protein 1.	0.610
BCL2	ABL1	ENSPTRP00000090293	ENSPTRP00000072918	BCL2 apoptosis regulator.	Tyrosine-protein kinase.	0.497
BCL2	CK820_G0012168	ENSPTRP00000090293	ENSPTRP00000061635	BCL2 apoptosis regulator.	ABL1 isoform 3.	0.400
BCL2	EIF2AK2	ENSPTRP00000090293	ENSPTRP00000065741	BCL2 apoptosis regulator.	Eukaryotic translation initiation factor 2-alpha kinase 2.	0.406
BCL2	IGF1R	ENSPTRP00000090293	ENSPTRP00000012792	BCL2 apoptosis regulator.	Tyrosine-protein kinase receptor.	0.591
BCL2	RHOA	ENSPTRP00000090293	ENSPTRP00000025759	BCL2 apoptosis regulator.	Ras homolog family member A.	0.476
BCL2	SMAD3	ENSPTRP00000090293	ENSPTRP00000090625	BCL2 apoptosis regulator.	Mothers against decapentaplegic homolog.	0.412
BMP2	NELL1	ENSPTRP00000022701	ENSPTRP00000005988	Bone morphogenetic protein 2.	Neural EGFL like 1.	0.410
BMP2	SMAD3	ENSPTRP00000022701	ENSPTRP00000090625	Bone morphogenetic protein 2.	Mothers against decapentaplegic homolog.	0.630
CK820_G0012168	BCL2	ENSPTRP00000061635	ENSPTRP00000090293	ABL1 isoform 3.	BCL2 apoptosis regulator.	0.400
CK820_G0012168	RHOA	ENSPTRP00000061635	ENSPTRP00000025759	ABL1 isoform 3.	Ras homolog family member A.	0.407
EIF2AK2	BCL2	ENSPTRP00000065741	ENSPTRP00000090293	Eukaryotic translation initiation factor 2-alpha kinase 2.	BCL2 apoptosis regulator.	0.406
FGFR2	IGF1R	ENSPTRP00000005308	ENSPTRP00000012792	Fibroblast growth factor receptor.	Tyrosine-protein kinase receptor.	0.430
FGFR2	ITGAV	ENSPTRP00000005308	ENSPTRP00000048970	Fibroblast growth factor receptor.	Integrin, alpha V (Vitronectin receptor, alpha polypeptide, antigen CD51); Belongs to the integrin alpha chain family.	0.464
FGFR2	NF2	ENSPTRP00000005308	ENSPTRP00000072446	Fibroblast growth factor receptor.	Neurofibromin 2 (Merlin).	0.405
IGF1R	BCL2	ENSPTRP00000012792	ENSPTRP00000090293	Tyrosine-protein kinase receptor.	BCL2 apoptosis regulator.	0.591
IGF1R	FGFR2	ENSPTRP00000012792	ENSPTRP00000005308	Tyrosine-protein kinase receptor.	Fibroblast growth factor receptor.	0.430