STRINGSTRING
KLRK1 KLRK1 LRRK2 LRRK2 FZD10 FZD10 FICD FICD SPRY2 SPRY2 ARRB2 ARRB2 LRCH1 LRCH1 RGN-2 RGN-2 MKKS MKKS RRP1B RRP1B ARFGEF1 ARFGEF1 RGN RGN AMOT AMOT CPEB2 CPEB2 SH3BP4 SH3BP4 RDX RDX GPSM1 GPSM1 WNK1 WNK1 CK820_G0021556 CK820_G0021556 SPRY1 SPRY1 LOC751039 LOC751039 TMED2 TMED2 F11R F11R ENSPTRP00000086247 ENSPTRP00000086247 ENSPTRP00000089747 ENSPTRP00000089747 PLXNB3 PLXNB3 BCAS3 BCAS3 TTC8 TTC8 TSC1 TSC1 ARL2 ARL2 GMIP GMIP BBS4 BBS4 DAB2IP DAB2IP RAP1GDS1 RAP1GDS1 RCC2 RCC2 HRAS HRAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KLRK1NKG2-D type II integral membrane protein; Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress- inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-exp [...] (216 aa)
LRRK2Leucine-rich repeat kinase 2. (2527 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
FICDFIC domain containing. (458 aa)
SPRY2Sprouty homolog 2. (338 aa)
ARRB2ARRB2 isoform 2. (430 aa)
LRCH1Leucine rich repeats and calponin homology domain containing 1. (761 aa)
RGN-2Regucalcin. (299 aa)
MKKSMcKusick-Kaufman syndrome. (570 aa)
RRP1BRibosomal RNA processing 1 homolog B. (758 aa)
ARFGEF1ADP-ribosylation factor guanine nucleotide-exchange factor 1(Brefeldin A-inhibited). (1849 aa)
RGNRegucalcin (Senescence marker protein-30). (299 aa)
AMOTAMOT isoform 2. (1094 aa)
CPEB2Cytoplasmic polyadenylation element binding protein 2. (1036 aa)
SH3BP4SH3 domain-binding protein 4. (963 aa)
RDXRDX isoform 3. (609 aa)
GPSM1G-protein-signaling modulator 1. (707 aa)
WNK1WNK1 isoform 4. (2833 aa)
CK820_G0021556TMED2 isoform 3. (200 aa)
SPRY1Sprouty homolog 1, antagonist of FGF signaling. (319 aa)
LOC751039Uncharacterized protein. (613 aa)
TMED2Transmembrane emp24 domain trafficking protein 2. (208 aa)
F11RF11R isoform 1. (322 aa)
ENSPTRP00000086247annotation not available (513 aa)
ENSPTRP00000089747annotation not available (156 aa)
PLXNB3PLXNB3 isoform 1. (1932 aa)
BCAS3BCAS3 microtubule associated cell migration factor. (950 aa)
TTC8Tetratricopeptide repeat domain 8. (531 aa)
TSC1TSC complex subunit 1. (1164 aa)
ARL2ARL2-SNX15 isoform 1; Belongs to the small GTPase superfamily. Arf family. (184 aa)
GMIPGEM interacting protein. (970 aa)
BBS4Bardet-Biedl syndrome 4. (519 aa)
DAB2IPDAB2 interacting protein. (1189 aa)
RAP1GDS1RAP1GDS1 isoform 18. (608 aa)
RCC2Regulator of chromosome condensation 2. (522 aa)
HRASV-Ha-ras Harvey rat sarcoma viral oncogene homolog. (189 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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