(14 nodes) High-density lipoprotein particle assembly network (Pan troglodytes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

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Your Input:
	PRKACG	Protein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (351 aa)
	APOE	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (317 aa)
	ENSPTRP00000091066	annotation not available (366 aa)
	ENSPTRP00000080550	Apolipoprotein A-I Proapolipoprotein A-I Truncated apolipoprotein A-I. (267 aa)
	ENSPTRP00000072249	annotation not available (396 aa)
	APOA2	Truncated apolipoprotein A-II; May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism; Belongs to the apolipoprotein A2 family. (133 aa)
	ABCA7	ABCA7 isoform 3. (1829 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
	APOA5	Apolipoprotein A5. (366 aa)
	APOA4	Apolipoprotein A4. (396 aa)
	APOA1	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity). (267 aa)
	PRKACA	PRKACA isoform 7; Belongs to the protein kinase superfamily. (289 aa)
	APOM	Apolipoprotein M. (188 aa)
	ABCA1	ATP-binding cassette, sub-family A (ABC1), member 1. (2264 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCA1	APOA1	ENSPTRP00000062700	ENSPTRP00000007404	ATP-binding cassette, sub-family A (ABC1), member 1.	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity).	0.943
ABCA1	APOA2	ENSPTRP00000062700	ENSPTRP00000069102	ATP-binding cassette, sub-family A (ABC1), member 1.	Truncated apolipoprotein A-II; May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism; Belongs to the apolipoprotein A2 family.	0.760
ABCA1	APOA5	ENSPTRP00000062700	ENSPTRP00000007401	ATP-binding cassette, sub-family A (ABC1), member 1.	Apolipoprotein A5.	0.447
ABCA1	APOE	ENSPTRP00000062700	ENSPTRP00000054411	ATP-binding cassette, sub-family A (ABC1), member 1.	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	0.851
ABCA1	ENSPTRP00000080550	ENSPTRP00000062700	ENSPTRP00000080550	ATP-binding cassette, sub-family A (ABC1), member 1.	Apolipoprotein A-I Proapolipoprotein A-I Truncated apolipoprotein A-I.	0.465
ABCA1	ENSPTRP00000091066	ENSPTRP00000062700	ENSPTRP00000091066	ATP-binding cassette, sub-family A (ABC1), member 1.	annotation not available	0.461
ABCA1	PRKACA	ENSPTRP00000062700	ENSPTRP00000018062	ATP-binding cassette, sub-family A (ABC1), member 1.	PRKACA isoform 7; Belongs to the protein kinase superfamily.	0.470
ABCA1	PRKACB	ENSPTRP00000062700	ENSPTRP00000042330	ATP-binding cassette, sub-family A (ABC1), member 1.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.472
ABCA1	PRKACG	ENSPTRP00000062700	ENSPTRP00000035898	ATP-binding cassette, sub-family A (ABC1), member 1.	Protein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily.	0.470
ABCA7	APOE	ENSPTRP00000063044	ENSPTRP00000054411	ABCA7 isoform 3.	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	0.645
APOA1	ABCA1	ENSPTRP00000007404	ENSPTRP00000062700	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity).	ATP-binding cassette, sub-family A (ABC1), member 1.	0.943
APOA1	APOA2	ENSPTRP00000007404	ENSPTRP00000069102	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity).	Truncated apolipoprotein A-II; May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism; Belongs to the apolipoprotein A2 family.	0.800
APOA1	APOA4	ENSPTRP00000007404	ENSPTRP00000007402	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity).	Apolipoprotein A4.	0.757
APOA1	APOA5	ENSPTRP00000007404	ENSPTRP00000007401	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity).	Apolipoprotein A5.	0.640
APOA1	APOE	ENSPTRP00000007404	ENSPTRP00000054411	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity).	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	0.862
APOA1	APOM	ENSPTRP00000007404	ENSPTRP00000030671	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity).	Apolipoprotein M.	0.601
APOA1	ENSPTRP00000072249	ENSPTRP00000007404	ENSPTRP00000072249	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity).	annotation not available	0.757
APOA1	ENSPTRP00000080550	ENSPTRP00000007404	ENSPTRP00000080550	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity).	Apolipoprotein A-I Proapolipoprotein A-I Truncated apolipoprotein A-I.	0.545
APOA1	ENSPTRP00000091066	ENSPTRP00000007404	ENSPTRP00000091066	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity).	annotation not available	0.640
APOA2	ABCA1	ENSPTRP00000069102	ENSPTRP00000062700	Truncated apolipoprotein A-II; May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism; Belongs to the apolipoprotein A2 family.	ATP-binding cassette, sub-family A (ABC1), member 1.	0.760