STRINGSTRING
HDAC2 HDAC2 BECN1-2 BECN1-2 SIRT1-2 SIRT1-2 PAX2 PAX2 EZH2-2 EZH2-2 MMP2 MMP2 HSF1 HSF1 AXL AXL ENSPTRP00000084892 ENSPTRP00000084892 CHUK CHUK FXN FXN SOD2 SOD2 MAPK13 MAPK13 AKT1 AKT1 IMPACT IMPACT PLEKHA1 PLEKHA1 ROMO1-2 ROMO1-2 ERCC6L2 ERCC6L2 IL6-2 IL6-2 ERN1 ERN1 ENSPTRP00000079686 ENSPTRP00000079686 PTPRK PTPRK AKR1C3 AKR1C3 PARK7 PARK7 RNF112 RNF112 FOS FOS PDGFD PDGFD FYN FYN PPARGC1B PPARGC1B EZH2 EZH2 ECT2 ECT2 CDKN2A CDKN2A ENSPTRP00000076878 ENSPTRP00000076878 SRC SRC ENSPTRP00000076749 ENSPTRP00000076749 PXN-2 PXN-2 LOC100615743 LOC100615743 ENSPTRP00000072952 ENSPTRP00000072952 ABL1 ABL1 ENSPTRP00000072507 ENSPTRP00000072507 ENSPTRP00000072249 ENSPTRP00000072249 LOC100610468 LOC100610468 PXN PXN ENSPTRP00000070902 ENSPTRP00000070902 CK820_G0021831 CK820_G0021831 AIFM1 AIFM1 MAPK10 MAPK10 EGFR EGFR IL6 IL6 TRPM2 TRPM2 ENSPTRP00000066724 ENSPTRP00000066724 RHOB RHOB ANKZF1 ANKZF1 NET1 NET1 NFE2L2 NFE2L2 ATP7A ATP7A SLC8A1 SLC8A1 RPS3 RPS3 LOC101057058 LOC101057058 ENSPTRP00000062077 ENSPTRP00000062077 CK820_G0012168 CK820_G0012168 KDM6B KDM6B TREX1 TREX1 RELA RELA MAPK3 MAPK3 SPHK1 SPHK1 SIRPA SIRPA GLRX2 GLRX2 CDK1 CDK1 ANXA1 ANXA1 PJVK PJVK PRKAA1 PRKAA1 STK25 STK25 TRPA1 TRPA1 BECN1 BECN1 ROMO1 ROMO1 SETX SETX MAP3K5 MAP3K5 TPM1 TPM1 MAPK8 MAPK8 ZNF277 ZNF277 BTK BTK HDAC6 HDAC6 AMBP AMBP FANCC FANCC SIGMAR1 SIGMAR1 AGAP3 AGAP3 NOS3 NOS3 NCF1 NCF1 NME8 NME8 AQP1 AQP1 TNFAIP3 TNFAIP3 ARG1 ARG1 EDN1 EDN1 RIPK1 RIPK1 MAPK9 MAPK9 FER FER UCP1 UCP1 PKD2 PKD2 SOD3 SOD3 ENSPTRP00000026978 ENSPTRP00000026978 PDCD10 PDCD10 PRKCD PRKCD MAPK1 MAPK1 SOD1 SOD1 MMP9 MMP9 OSER1 OSER1 MAP1LC3A MAP1LC3A PCNA PCNA LOC458036 LOC458036 CRYGD CRYGD FABP1 FABP1 CYP1B1 CYP1B1 MPV17 MPV17 ZNF580 ZNF580 KLF2 KLF2 PRDX2 PRDX2 MPO MPO PDK2 PDK2 PCGF2 PCGF2 MAPK7 MAPK7 NQO1 NQO1 SMPD3 SMPD3 MT3 MT3 RIPK3 RIPK3 CAMKK2 CAMKK2 STAT6 STAT6 APOA4 APOA4 IL18BP IL18BP CCS CCS PRDX5 PRDX5 CAT CAT BNIP3 BNIP3 PRDX3 PRDX3 PPIF PPIF SIRT1 SIRT1 PRDX1 PRDX1 ADPRHL2 ADPRHL2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HDAC2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (581 aa)
BECN1-2BECN1 isoform 3. (371 aa)
SIRT1-2Sirtuin 1. (751 aa)
PAX2PAX2 isoform 1. (417 aa)
EZH2-2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (751 aa)
MMP2Matrix metallopeptidase 2. (660 aa)
HSF1Heat shock transcription factor 1. (529 aa)
AXLAXL receptor tyrosine kinase. (894 aa)
ENSPTRP00000084892annotation not available (374 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (760 aa)
FXNFXN isoform 1. (210 aa)
SOD2Superoxide dismutase [Mn], mitochondrial; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (238 aa)
MAPK13Mitogen-activated protein kinase 13; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studie [...] (366 aa)
AKT1AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa)
IMPACTIMPACT isoform 1. (320 aa)
PLEKHA1Pleckstrin homology domain containing, family A (Phosphoinositide binding specific) member 1. (404 aa)
ROMO1-2Reactive oxygen species modulator 1. (79 aa)
ERCC6L2ERCC excision repair 6 like 2. (712 aa)
IL6-2Interleukin 6. (234 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (977 aa)
ENSPTRP00000079686annotation not available (213 aa)
PTPRKProtein tyrosine phosphatase receptor type K. (1472 aa)
AKR1C3Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II). (323 aa)
PARK7PARK7 isoform 1. (189 aa)
RNF112Ring finger protein 112. (631 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
PDGFDPlatelet derived growth factor D. (370 aa)
FYNTyrosine-protein kinase. (537 aa)
PPARGC1BPPARGC1B isoform 2. (1023 aa)
EZH2Enhancer of zeste homolog 2. (754 aa)
ECT2Epithelial cell transforming sequence 2 oncogene. (958 aa)
CDKN2ACyclin-dependent kinase inhibitor 2A (Melanoma, p16, inhibits CDK4). (173 aa)
ENSPTRP00000076878annotation not available (139 aa)
SRCTyrosine-protein kinase. (542 aa)
ENSPTRP00000076749annotation not available (243 aa)
PXN-2PXN isoform 9. (1081 aa)
LOC100615743Peroxiredoxin-1-like. (171 aa)
ENSPTRP00000072952annotation not available (212 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
ENSPTRP00000072507annotation not available (659 aa)
ENSPTRP00000072249annotation not available (396 aa)
LOC100610468Gamma-crystallin F-like. (161 aa)
PXNPXN isoform 20. (1078 aa)
ENSPTRP00000070902annotation not available (168 aa)
CK820_G0021831RPS3 isoform 18; Belongs to the universal ribosomal protein uS3 family. (100 aa)
AIFM1Apoptosis-inducing factor, mitochondrion-associated, 1. (603 aa)
MAPK10Mitogen-activated protein kinase. (551 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
IL6Interleukin 6 (Interferon, beta 2). (234 aa)
TRPM2TRPM2 isoform 4. (1393 aa)
ENSPTRP00000066724annotation not available (166 aa)
RHOBRas homolog gene family, member B. (286 aa)
ANKZF1Ankyrin repeat and zinc finger domain containing 1. (733 aa)
NET1Neuroepithelial cell transforming 1. (603 aa)
NFE2L2Nuclear factor (Erythroid-derived 2)-like 2. (605 aa)
ATP7AATPase, Cu++ transporting, alpha polypeptide. (1500 aa)
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
RPS3RPS3 isoform 13; Belongs to the universal ribosomal protein uS3 family. (243 aa)
LOC10105705840S ribosomal protein S3 pseudogene. (270 aa)
ENSPTRP00000062077annotation not available (236 aa)
CK820_G0012168ABL1 isoform 3. (1149 aa)
KDM6BLysine demethylase 6B. (1679 aa)
TREX1Three prime repair exonuclease 1. (369 aa)
RELAV-rel reticuloendotheliosis viral oncogene homolog A (Avian). (551 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
SPHK1Sphingosine kinase 1. (470 aa)
SIRPASignal-regulatory protein alpha. (504 aa)
GLRX2GLRX2 isoform 1. (165 aa)
CDK1Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
ANXA1Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of Fthe formyl peptide receptors (By similarity). Contribu [...] (346 aa)
PJVKDFNB59 isoform 1. (352 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
STK25Serine/threonine kinase 25. (426 aa)
TRPA1Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family. (1119 aa)
BECN1Beclin 1, autophagy related. (450 aa)
ROMO1Reactive oxygen species modulator 1. (79 aa)
SETXSETX isoform 1. (2668 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1374 aa)
TPM1TPM1 isoform 3; Belongs to the tropomyosin family. (326 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
ZNF277ZNF277 isoform 1. (456 aa)
BTKBTK isoform 2. (693 aa)
HDAC6Histone deacetylase 6. (146 aa)
AMBPAlpha-1-microglobulin/bikunin precursor. (364 aa)
FANCCFanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. (558 aa)
SIGMAR1Sigma non-opioid intracellular receptor 1. (223 aa)
AGAP3AGAP3 isoform 5. (864 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1203 aa)
NCF1Neutrophil cytosolic factor 1. (390 aa)
NME8NME/NM23 family member 8. (588 aa)
AQP1Aquaporin-1 isoform X2. (269 aa)
TNFAIP3Tumor necrosis factor, alpha-induced protein 3. (790 aa)
ARG1Arginase. (322 aa)
EDN1EDN1 isoform 1. (212 aa)
RIPK1Receptor (TNFRSF)-interacting serine-threonine kinase 1. (671 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
UCP1Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (307 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (968 aa)
SOD3Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (240 aa)
ENSPTRP00000026978annotation not available (268 aa)
PDCD10Programmed cell death 10. (212 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (154 aa)
MMP9Matrix metallopeptidase 9. (699 aa)
OSER1Oxidative stress responsive serine rich 1. (292 aa)
MAP1LC3AMicrotubule associated protein 1 light chain 3 alpha. (125 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
LOC458036T0061165 isoform 1. (427 aa)
CRYGDCrystallin gamma D; Belongs to the beta/gamma-crystallin family. (174 aa)
FABP1Fatty acid binding protein 1. (127 aa)
CYP1B1Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (543 aa)
MPV17Mitochondrial inner membrane protein MPV17; Belongs to the peroxisomal membrane protein PXMP2/4 family. (176 aa)
ZNF580Zinc finger protein 580. (172 aa)
KLF2Kruppel-like factor 2 (Lung). (355 aa)
PRDX2PRDX2 isoform 1. (198 aa)
MPOMyeloperoxidase. (745 aa)
PDK2Protein-serine/threonine kinase. (407 aa)
PCGF2Polycomb group ring finger 2. (344 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (816 aa)
NQO1NAD(P)H quinone dehydrogenase 1. (274 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (655 aa)
MT3MT3 isoform 5; Belongs to the metallothionein superfamily. Type 1 family. (113 aa)
RIPK3Receptor interacting serine/threonine kinase 3. (518 aa)
CAMKK2Calcium/calmodulin-dependent protein kinase kinase 2, beta. (588 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
APOA4Apolipoprotein A4. (396 aa)
IL18BPInterleukin 18 binding protein. (194 aa)
CCSCopper chaperone for superoxide dismutase. (274 aa)
PRDX5Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily. (214 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
BNIP3BCL2 interacting protein 3. (259 aa)
PRDX3PRDX3 isoform 1. (256 aa)
PPIFPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (207 aa)
SIRT1SIRT1 isoform 2. (751 aa)
PRDX1PRDX1 isoform 1. (199 aa)
ADPRHL2ADPRHL2 isoform 1. (364 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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