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CACNG7 CACNG7 FKBP1B FKBP1B CACNG2 CACNG2 SMDT1 SMDT1 MCUB MCUB CACNB4 CACNB4 CACNA1I CACNA1I TMEM249 TMEM249 CATSPERD CATSPERD ENSPTRP00000063671 ENSPTRP00000063671 PKD1L1 PKD1L1 RYR2 RYR2 CK820_G0056924 CK820_G0056924 CACNA1G CACNA1G PDE4B PDE4B PDE4D PDE4D PKD1L1-2 PKD1L1-2 PTPA-2 PTPA-2 CACNA2D1 CACNA2D1 CACNA2D4 CACNA2D4 CACNA1S CACNA1S CACNA1D CACNA1D MCU MCU MICU1 MICU1 CACNG4 CACNG4 ENSPTRP00000078278 ENSPTRP00000078278 LOC107966461-2 LOC107966461-2 HSPA2 HSPA2 ATP2A1 ATP2A1 CALM1 CALM1 CACNA1A CACNA1A CK820_G0054628 CK820_G0054628 TRPV5 TRPV5 CACNB1 CACNB1 CACNB3 CACNB3 PTPA PTPA CACNA2D2 CACNA2D2 TMEM262 TMEM262 ENSPTRP00000090392 ENSPTRP00000090392 CK820_G0030361 CK820_G0030361 TMEM249-2 TMEM249-2 CATSPERE CATSPERE RYR1 RYR1 ENSPTRP00000093907 ENSPTRP00000093907 CATSPER4 CATSPER4 CACHD1 CACHD1 CASQ2 CASQ2 CACNA1E CACNA1E PKD2L1 PKD2L1 CATSPER1 CATSPER1 CACNA1C CACNA1C STAC3 STAC3 ORAI1 ORAI1 MICU2 MICU2 AKAP6 AKAP6 CATSPERB CATSPERB LOC107966461 LOC107966461 CACNA1H CACNA1H CACNG1 CACNG1 PRKACA PRKACA CATSPERG CATSPERG CALM3 CALM3 CACNG6 CACNG6 CATSPER3 CATSPER3 TRPV5-2 TRPV5-2 MICU3 MICU3 CACNA1B CACNA1B CACNA1F CACNA1F TRPC5 TRPC5 EFCAB9 EFCAB9 TRPV6 TRPV6 CACNB2 CACNB2 TRPC4 TRPC4 CACNG8 CACNG8 CACNA2D3 CACNA2D3 ASPH ASPH
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (275 aa)
FKBP1BPeptidylprolyl isomerase. (108 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
SMDT1SMDT1 isoform 1. (107 aa)
MCUBMitochondrial calcium uniporter dominant negative beta subunit. (336 aa)
CACNB4Calcium voltage-gated channel auxiliary subunit beta 4. (520 aa)
CACNA1IVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2223 aa)
TMEM249Transmembrane protein 249. (235 aa)
CATSPERDCATSPERD isoform 1. (798 aa)
ENSPTRP00000063671annotation not available (122 aa)
PKD1L1PKD1L1 isoform 1. (2857 aa)
RYR2RYR2 isoform 1. (4941 aa)
CK820_G0056924NPIPA2 isoform 1. (277 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2377 aa)
PDE4BPhosphodiesterase. (736 aa)
PDE4DPhosphodiesterase. (809 aa)
PKD1L1-2Polycystin 1 like 1, transient receptor potential channel interacting. (2857 aa)
PTPA-2Serine/threonine-protein phosphatase 2A activator; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. (373 aa)
CACNA2D1Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (1103 aa)
CACNA2D4CACNA2D4 isoform 6. (1154 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1873 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
MCUCoiled-coil domain containing 109A. (352 aa)
MICU1Mitochondrial calcium uptake 1. (482 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (327 aa)
ENSPTRP00000078278annotation not available (260 aa)
LOC107966461-2Cation channel sperm-associated protein 2. (563 aa)
HSPA2Heat shock 70kDa protein 2; Belongs to the heat shock protein 70 family. (642 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1068 aa)
CALM1CALM1 isoform 3; Belongs to the calmodulin family. (150 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2504 aa)
CK820_G0054628PKD1 isoform 4. (3384 aa)
TRPV5Transient receptor potential cation channel subfamily V member 5. (732 aa)
CACNB1Calcium voltage-gated channel auxiliary subunit beta 1. (626 aa)
CACNB3Calcium channel, voltage-dependent, beta 3 subunit. (487 aa)
PTPAProtein phosphatase 2 phosphatase activator. (357 aa)
CACNA2D2Calcium voltage-gated channel auxiliary subunit alpha2delta 2. (1156 aa)
TMEM262Transmembrane protein 262. (116 aa)
ENSPTRP00000090392annotation not available (93 aa)
CK820_G0030361RYR1 isoform 5. (4901 aa)
TMEM249-2Transmembrane protein 249. (235 aa)
CATSPERECatsper channel auxiliary subunit epsilon. (959 aa)
RYR1RYR1 isoform 3. (5037 aa)
ENSPTRP00000093907annotation not available (528 aa)
CATSPER4Cation channel sperm associated 4. (464 aa)
CACHD1CACHD1 isoform 4. (1274 aa)
CASQ2Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (399 aa)
CACNA1EVoltage-dependent R-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. (2313 aa)
PKD2L1Polycystin 2 like 1, transient receptor potential cation channel. (805 aa)
CATSPER1Cation channel sperm associated 1. (780 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2186 aa)
STAC3SH3 and cysteine rich domain 3. (364 aa)
ORAI1ORAI1 isoform 1. (301 aa)
MICU2EF-hand domain family, member A1. (434 aa)
AKAP6A-kinase anchoring protein 6. (2319 aa)
CATSPERBCATSPERB isoform 2. (1086 aa)
LOC107966461CATSPER2 isoform 1. (563 aa)
CACNA1HCACNA1H isoform 1. (2240 aa)
CACNG1Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics. (222 aa)
PRKACAPRKACA isoform 7; Belongs to the protein kinase superfamily. (289 aa)
CATSPERGCation channel sperm associated auxiliary subunit gamma. (1159 aa)
CALM3Calmodulin 1 (Phosphorylase kinase, delta); Belongs to the calmodulin family. (149 aa)
CACNG6Voltage-dependent calcium channel gamma-6 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (260 aa)
CATSPER3Cation channel sperm associated 3. (398 aa)
TRPV5-2Transient receptor potential cation channel subfamily V member 5; Belongs to the transient receptor (TC 1.A.4) family. (732 aa)
MICU3Mitochondrial calcium uptake family member 3. (530 aa)
CACNA1BVoltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. (2312 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1984 aa)
TRPC5Transient receptor potential cation channel subfamily C member 5; Belongs to the transient receptor (TC 1.A.4) family. (973 aa)
EFCAB9EF-hand calcium binding domain 9. (197 aa)
TRPV6Transient receptor potential cation channel subfamily V member 6. (765 aa)
CACNB2Calcium voltage-gated channel auxiliary subunit beta 2. (660 aa)
TRPC4Transient receptor potential cation channel, subfamily C, member 4; Belongs to the transient receptor (TC 1.A.4) family. (977 aa)
CACNG8Voltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (427 aa)
CACNA2D3CACNA2D3 isoform 3. (1091 aa)
ASPHASPH isoform 1. (762 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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