STRINGSTRING
MED12 MED12 MED14 MED14 RAF1 RAF1 BRAF-2 BRAF-2 MED28 MED28 ENSPTRP00000090382 ENSPTRP00000090382 NR2E1-2 NR2E1-2 STAT3 STAT3 RIF1 RIF1 ASCL2 ASCL2 SKI SKI BCL9 BCL9 VPS72 VPS72 NODAL NODAL BMPR1A BMPR1A FGF4 FGF4 YAP1 YAP1 BCL9L BCL9L CUL4A CUL4A NOG NOG SOX9 SOX9 SIX2 SIX2 LIF LIF KIT KIT MED7 MED7 MED30 MED30 KLF4 KLF4 SMC1A SMC1A REST REST LDB1 LDB1 LIG4 LIG4 SOX2 SOX2 NKAP NKAP NIPBL NIPBL SOX4 SOX4 ENSPTRP00000052836 ENSPTRP00000052836 ZHX2 ZHX2 SFRP1 SFRP1 GATA2 GATA2 KLF10 KLF10 WNT9B WNT9B ENSPTRP00000059998 ENSPTRP00000059998 MED21 MED21 ENSPTRP00000063941 ENSPTRP00000063941 HES1 HES1 MED27 MED27 ENSPTRP00000064416 ENSPTRP00000064416 WNT7A WNT7A ZFP36L2 ZFP36L2 LRP5 LRP5 MED15 MED15 CDX2 CDX2 NR2E1 NR2E1 SALL4 SALL4 WNT9B-2 WNT9B-2 CDKN2A CDKN2A CUL4A-2 CUL4A-2 RBPJ RBPJ BRAF BRAF LDB2 LDB2 FGF10 FGF10 MED6 MED6 SPI1 SPI1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MED12Mediator of RNA polymerase II transcription subunit 12; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifi [...] (2182 aa)
MED14Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1454 aa)
RAF1RAF1 isoform 2; Belongs to the protein kinase superfamily. (668 aa)
BRAF-2BRAF isoform 2. (766 aa)
MED28Mediator complex subunit 28. (178 aa)
ENSPTRP00000090382annotation not available (493 aa)
NR2E1-2Nuclear receptor subfamily 2 group E member 1. (385 aa)
STAT3Signal transducer and activator of transcription. (790 aa)
RIF1Replication timing regulatory factor 1. (2473 aa)
ASCL2Achaete-scute family bHLH transcription factor 2. (193 aa)
SKIV-ski sarcoma viral oncogene homolog (Avian). (736 aa)
BCL9BCL9 transcription coactivator. (1426 aa)
VPS72Vacuolar protein sorting 72 homolog. (375 aa)
NODALNODAL isoform 2. (347 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
YAP1Yes-associated protein 1. (508 aa)
BCL9LB-cell CLL/lymphoma 9-like. (1499 aa)
CUL4ACUL4A isoform 5; Belongs to the cullin family. (759 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
SIX2SIX homeobox 2. (291 aa)
LIFLeukemia inhibitory factor (Cholinergic differentiation factor). (202 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
MED7Mediator of RNA polymerase II transcription subunit 7; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. (233 aa)
MED30Mediator complex subunit 30. (178 aa)
KLF4Kruppel-like factor 4 (Gut). (479 aa)
SMC1AStructural maintenance of chromosomes protein. (1233 aa)
RESTRE1 silencing transcription factor. (1097 aa)
LDB1LIM domain binding 1. (411 aa)
LIG4DNA ligase. (911 aa)
SOX2SRY-box transcription factor 2. (319 aa)
NKAPNFKB activating protein. (415 aa)
NIPBLNipped-B protein. (2804 aa)
SOX4Transcription factor SOX. (474 aa)
ENSPTRP00000052836annotation not available (439 aa)
ZHX2Zinc fingers and homeoboxes 2. (837 aa)
SFRP1Secreted frizzled-related protein 1. (314 aa)
GATA2GATA binding protein 2. (480 aa)
KLF10Kruppel-like factor 10. (480 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
ENSPTRP00000059998annotation not available (311 aa)
MED21Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (159 aa)
ENSPTRP00000063941annotation not available (134 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
MED27Mediator complex subunit 27. (311 aa)
ENSPTRP00000064416annotation not available (502 aa)
WNT7AProtein Wnt-7a; Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta- catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes. Required for normal [...] (349 aa)
ZFP36L2Zinc finger protein 36, C3H type-like 2. (492 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1606 aa)
MED15Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (786 aa)
CDX2Caudal type homeobox 2. (313 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (422 aa)
SALL4SALL4 isoform 1. (1053 aa)
WNT9B-2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
CDKN2ACyclin-dependent kinase inhibitor 2A (Melanoma, p16, inhibits CDK4). (173 aa)
CUL4A-2Cullin 4A. (763 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (500 aa)
BRAFBRAF isoform 1; Belongs to the protein kinase superfamily. (767 aa)
LDB2LIM domain binding 2. (373 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
MED6Mediator of RNA polymerase II transcription subunit 6; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (249 aa)
SPI1Spi-1 proto-oncogene. (270 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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