STRINGSTRING
PIFO PIFO VANGL2 VANGL2 NODAL NODAL MICAL2 MICAL2 CK820_G0005744 CK820_G0005744 APLNR APLNR FOLR1 FOLR1 YAP1 YAP1 FOXN4 FOXN4 HIF1A HIF1A PSEN1 PSEN1 ASB2 ASB2 MESP1 MESP1 TBX6 TBX6 NDRG4 NDRG4 MED1 MED1 CCDC103 CCDC103 TBX2 TBX2 CCDC40 CCDC40 MEGF8 MEGF8 BBS5 BBS5 IHH IHH MKKS MKKS IFT52 IFT52 SOX18 SOX18 ARL13B ARL13B IFT57 IFT57 IFT122 IFT122 PKD2 PKD2 PITX2 PITX2 BBS7 BBS7 EDNRA EDNRA HAND1 HAND1 NKX2-5 NKX2-5 EDN1 EDN1 SRF SRF AHI1 AHI1 DLL1 DLL1 TBX20 TBX20 SMO SMO NKX2-6 NKX2-6 SOX17 SOX17 FOXH1 FOXH1 ENG ENG NOTCH1 NOTCH1 SETDB2 SETDB2 CTNNB1 CTNNB1 DNAAF1 DNAAF1 LBX1 LBX1 HAND2 HAND2 CCDC39 CCDC39 WNT3A WNT3A FOXH1-2 FOXH1-2 FOXC2 FOXC2 NOTO NOTO BBS4 BBS4 PLXNA4 PLXNA4 S1PR2 S1PR2 APELA APELA C2CD3 C2CD3 HES1 HES1 RYR2 RYR2 FOXC1 FOXC1 ZIC3 ZIC3 SMO-2 SMO-2 IFT172 IFT172 SUFU SUFU CK820_G0042370 CK820_G0042370 TGFBR2 TGFBR2 FGF8 FGF8 SHH SHH ACVR1 ACVR1 NOTCH2 NOTCH2 GATA4 GATA4 CDC42 CDC42 CK820_G0021556 CK820_G0021556 CITED2 CITED2 TEAD2 TEAD2 TMED2 TMED2 STIL STIL TBX3 TBX3 WNT5A WNT5A CLUAP1 CLUAP1 ENSPTRP00000089747 ENSPTRP00000089747 ECE1 ECE1 MEF2C MEF2C SMAD3 SMAD3 OVOL2 OVOL2 MIB1 MIB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIFOPrimary cilia formation. (191 aa)
VANGL2Vang-like protein. (521 aa)
NODALNODAL isoform 2. (347 aa)
MICAL2Microtubule associated monooxygenase, calponin and LIM domain containing 2. (1124 aa)
CK820_G0005744MICALCL isoform 1. (689 aa)
APLNRAPLNR isoform 1; Belongs to the G-protein coupled receptor 1 family. (380 aa)
FOLR1Folate receptor alpha. (257 aa)
YAP1Yes-associated protein 1. (508 aa)
FOXN4FOXN4 isoform 2. (517 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
ASB2Ankyrin repeat and SOCS box containing 2. (635 aa)
MESP1Mesoderm posterior bHLH transcription factor 1. (268 aa)
TBX6T-box transcription factor 6. (443 aa)
NDRG4NDRG family member 4. (226 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1581 aa)
CCDC103Coiled-coil domain containing 103. (242 aa)
TBX2T-box transcription factor 2. (712 aa)
CCDC40CCDC40 isoform 3. (1142 aa)
MEGF8Multiple EGF like domains 8. (2842 aa)
BBS5T0004560 isoform 1. (341 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
MKKSMcKusick-Kaufman syndrome. (570 aa)
IFT52Intraflagellar transport 52 homolog. (437 aa)
SOX18SOX18 isoform 1. (384 aa)
ARL13BADP ribosylation factor like GTPase 13B. (428 aa)
IFT57Intraflagellar transport 57 homolog. (429 aa)
IFT122IFT122 isoform 10. (1286 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (968 aa)
PITX2Homeobox protein. (324 aa)
BBS7Bardet-Biedl syndrome 7 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. (715 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
HAND1Heart and neural crest derivatives expressed 1. (215 aa)
NKX2-5NKX2-5 isoform 1. (325 aa)
EDN1EDN1 isoform 1. (212 aa)
SRFSerum response factor (C-fos serum response element-binding transcription factor). (508 aa)
AHI1Abelson helper integration site 1. (1196 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
TBX20T-box transcription factor 20. (447 aa)
SMOSMO isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
NKX2-6NKX2-6 isoform 1. (301 aa)
SOX17SOX17 isoform 1. (416 aa)
FOXH1FOXH1 isoform 1. (365 aa)
ENGENG isoform 1. (658 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
SETDB2SET domain bifurcated histone lysine methyltransferase 2. (719 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
DNAAF1Dynein assembly factor 1, axonemal. (725 aa)
LBX1Ladybird homeobox 1. (281 aa)
HAND2Heart and neural crest derivatives expressed 2. (217 aa)
CCDC39Coiled-coil domain containing 39. (941 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
FOXH1-2Forkhead box H1. (365 aa)
FOXC2Forkhead box C2 (MFH-1, mesenchyme forkhead 1). (501 aa)
NOTONotochord homeobox. (251 aa)
BBS4Bardet-Biedl syndrome 4. (519 aa)
PLXNA4PLXNA4 isoform 1. (1894 aa)
S1PR2Sphingosine-1-phosphate receptor 2; Belongs to the G-protein coupled receptor 1 family. (353 aa)
APELAApelin receptor early endogenous ligand. (54 aa)
C2CD3C2CD3 isoform 3. (2298 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
RYR2RYR2 isoform 1. (4941 aa)
FOXC1FOXC1 isoform 1. (550 aa)
ZIC3Zic family member 3. (466 aa)
SMO-2Smoothened, frizzled class receptor. (786 aa)
IFT172Intraflagellar transport 172 homolog. (1767 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (519 aa)
CK820_G0042370TEAD2 isoform 6. (427 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (581 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
NOTCH2NOTCH2 isoform 1. (2612 aa)
GATA4GATA binding protein 4. (443 aa)
CDC42Cell division cycle 42 (GTP binding protein, 25kDa). (191 aa)
CK820_G0021556TMED2 isoform 3. (200 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
TEAD2TEA domain transcription factor 2. (451 aa)
TMED2Transmembrane emp24 domain trafficking protein 2. (208 aa)
STILSTIL centriolar assembly protein. (1288 aa)
TBX3T-box transcription factor 3. (743 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
CLUAP1CLUAP1 isoform 5. (432 aa)
ENSPTRP00000089747annotation not available (156 aa)
ECE1Endothelin converting enzyme 1. (770 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
SMAD3Mothers against decapentaplegic homolog. (442 aa)
OVOL2Ovo like zinc finger 2. (275 aa)
MIB1Mindbomb E3 ubiquitin protein ligase 1. (1014 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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