STRINGSTRING
PIH1D1 PIH1D1 SPHK2 SPHK2 PWWP2A PWWP2A CHEK1 CHEK1 PIWIL2 PIWIL2 ENSPTRP00000066171 ENSPTRP00000066171 RPS6KA5 RPS6KA5 RUVBL2 RUVBL2 GATA3 GATA3 ENSPTRP00000063205 ENSPTRP00000063205 PWWP2B PWWP2B PAXIP1 PAXIP1 SETD5 SETD5 GATA2 GATA2 MAPK3 MAPK3 TWIST1 TWIST1 SIN3A SIN3A ARRB1 ARRB1 SMARCB1 SMARCB1 NOC2L NOC2L FOXP3 FOXP3 SNAI2 SNAI2 BAZ1B BAZ1B ATG5 ATG5 ZNF451 ZNF451 DEK DEK TGFB1 TGFB1 SMAD4 SMAD4 WBP2 WBP2 ENSPTRP00000069476 ENSPTRP00000069476 KMT2E KMT2E BRCA1 BRCA1 ENSPTRP00000070902 ENSPTRP00000070902 ENSPTRP00000072783 ENSPTRP00000072783 CK820_G0021068 CK820_G0021068 FLCN FLCN CTBP1 CTBP1 PARK7 PARK7 LOC460817 LOC460817 ENSPTRP00000079733 ENSPTRP00000079733 ZMPSTE24 ZMPSTE24 ENSPTRP00000080780 ENSPTRP00000080780 BRD7 BRD7 NFYA NFYA GLYR1 GLYR1 ENSPTRP00000083779 ENSPTRP00000083779 SPI1 SPI1 SDR16C5 SDR16C5 AUTS2 AUTS2 NFYC NFYC MYO1C MYO1C SNCA SNCA NOS1 NOS1 SIRT1-2 SIRT1-2 NFYB NFYB KAT7 KAT7 KAT2A KAT2A TADA2A TADA2A MYOCD MYOCD MYBBP1A MYBBP1A CTCF CTCF LIF LIF ISL1 ISL1 SMARCA5 SMARCA5 THAP7 THAP7 PPARGC1A PPARGC1A TADA2B TADA2B SF3B1 SF3B1 IWS1 IWS1 IL1B IL1B RPS6KA4 RPS6KA4 DDX21 DDX21 SIRT1 SIRT1 ERCC6 ERCC6 MUC1 MUC1 PYGO2 PYGO2 ARID5A ARID5A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIH1D1PIH1 domain containing 1. (321 aa)
SPHK2Sphingosine kinase 2. (255 aa)
PWWP2APWWP domain containing 2A. (755 aa)
CHEK1CHEK1 isoform 10. (485 aa)
PIWIL2Piwi-like RNA-mediated gene silencing 2; Belongs to the argonaute family. (973 aa)
ENSPTRP00000066171annotation not available (772 aa)
RPS6KA5Ribosomal protein S6 kinase. (802 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa)
GATA3GATA binding protein 3. (444 aa)
ENSPTRP00000063205annotation not available (297 aa)
PWWP2BPWWP domain containing 2B. (589 aa)
PAXIP1PAX interacting protein 1. (1067 aa)
SETD5SET domain containing 5. (1442 aa)
GATA2GATA binding protein 2. (480 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
TWIST1TWIST1 isoform 2. (163 aa)
SIN3ASIN3 transcription regulator family member A. (1273 aa)
ARRB1ARRB1 isoform 1. (418 aa)
SMARCB1SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family. (394 aa)
NOC2LNOC2L isoform 4. (745 aa)
FOXP3FOXP3 isoform 4. (456 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
BAZ1BBromodomain adjacent to zinc finger domain, 1B. (1484 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
ZNF451Zinc finger protein 451. (1060 aa)
DEKDEK proto-oncogene. (374 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
WBP2WW domain-binding protein 2. (261 aa)
ENSPTRP00000069476annotation not available (708 aa)
KMT2EMyeloid/lymphoid or mixed-lineage leukemia 5. (1877 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1884 aa)
ENSPTRP00000070902annotation not available (168 aa)
ENSPTRP00000072783annotation not available (203 aa)
CK820_G0021068Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (341 aa)
FLCNT0180863 isoform 1. (579 aa)
CTBP1C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (440 aa)
PARK7PARK7 isoform 1. (189 aa)
LOC460817Bromodomain-containing protein 7 pseudogene. (397 aa)
ENSPTRP00000079733annotation not available (1251 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (480 aa)
ENSPTRP00000080780annotation not available (683 aa)
BRD7Bromodomain containing 7. (652 aa)
NFYANuclear transcription factor Y subunit alpha. (347 aa)
GLYR1Glyoxylate reductase 1 homolog. (553 aa)
ENSPTRP00000083779annotation not available (309 aa)
SPI1Spi-1 proto-oncogene. (270 aa)
SDR16C5SDR16C5 isoform 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (328 aa)
AUTS2Activator of transcription and developmental regulator AUTS2. (1259 aa)
NFYCNuclear transcription factor Y subunit gamma. (458 aa)
MYO1CMYO1C isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1063 aa)
SNCAAlpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] (140 aa)
NOS1Nitric oxide synthase 1. (1468 aa)
SIRT1-2Sirtuin 1. (751 aa)
NFYBNuclear transcription factor Y subunit beta. (208 aa)
KAT7Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (611 aa)
KAT2AHistone acetyltransferase KAT2A isoform X1. (837 aa)
TADA2ATranscriptional adapter. (443 aa)
MYOCDMYOCD isoform 2. (986 aa)
MYBBP1AMYB binding protein (P160) 1a. (1338 aa)
CTCFCCCTC-binding factor (Zinc finger protein). (727 aa)
LIFLeukemia inhibitory factor (Cholinergic differentiation factor). (202 aa)
ISL1ISL LIM homeobox 1. (349 aa)
SMARCA5SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1052 aa)
THAP7THAP domain containing 7. (309 aa)
PPARGC1APPARG coactivator 1 alpha. (809 aa)
TADA2BTranscriptional adapter. (420 aa)
SF3B1Splicing factor 3b, subunit 1, 155kDa. (1267 aa)
IWS1Interacts with SUPT6H, CTD assembly factor 1. (819 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
RPS6KA4Ribosomal protein S6 kinase. (772 aa)
DDX21DEAD (Asp-Glu-Ala-Asp) box polypeptide 21. (783 aa)
SIRT1SIRT1 isoform 2. (751 aa)
ERCC6ERCC6 isoform 1. (1491 aa)
MUC1Mucin 1, cell surface associated. (484 aa)
PYGO2Pygopus family PHD finger 2. (405 aa)
ARID5AAT rich interactive domain 5A (MRF1-like). (594 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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