STRINGSTRING
PSEN1 PSEN1 ALDH1A2 ALDH1A2 IFT140 IFT140 RPGRIP1L RPGRIP1L TMEM107 TMEM107 B9D1 B9D1 MED1 MED1 WNT3 WNT3 NOG NOG MKS1 MKS1 SKI SKI ALX3 ALX3 CRABP2 CRABP2 PRRX1 PRRX1 PLXNA2 PLXNA2 FLVCR1 FLVCR1 TBX2 TBX2 TGFB2 TGFB2 TBX4 TBX4 SOX9 SOX9 RNF165 RNF165 SMAD4 SMAD4 MEGF8 MEGF8 OSR1 OSR1 PKDCC PKDCC AFF3 AFF3 MAP3K20 MAP3K20 LNPK LNPK EVX2 EVX2 HOXD13 HOXD13 HOXD10 HOXD10 COL3A1 COL3A1 IHH IHH GDF5 GDF5 IFT52 IFT52 BMP7 BMP7 TP63 TP63 ZNF141 ZNF141 WDR19 WDR19 INTU INTU SFRP2 SFRP2 CPLANE1 CPLANE1 PITX1 PITX1 PBX2 PBX2 GNA12 GNA12 HOXA11 HOXA11 GLI3 GLI3 SEMA3C SEMA3C DLX5 DLX5 CHD7 CHD7 RDH10 RDH10 GRHL2 GRHL2 EXT1 EXT1 RECK RECK PCSK5 PCSK5 NOTCH1 NOTCH1 LMBR1 LMBR1 COL2A1 COL2A1 FZD6 FZD6 WDPCP WDPCP CTNNB1 CTNNB1 FRAS1 FRAS1 HOXA13-2 HOXA13-2 TWIST1 TWIST1 NIPBL NIPBL ZNF358 ZNF358 EN1 EN1 HDAC2 HDAC2 BAK1 BAK1 SOX4 SOX4 HAND2 HAND2 ASPH ASPH TMEM231 TMEM231 MSX1 MSX1 SP8 SP8 DLX6 DLX6 HOXD12 HOXD12 PBX1 PBX1 LOC104003639 LOC104003639 HOXA13 HOXA13 C2CD3 C2CD3 FMN1 FMN1 RSPO2 RSPO2 ENSPTRP00000064416 ENSPTRP00000064416 SALL1 SALL1 WNT7A WNT7A RUNX2 RUNX2 ZIC3 ZIC3 HOXA10 HOXA10 TMEM107-2 TMEM107-2 ENSPTRP00000066776 ENSPTRP00000066776 HOXA10-2 HOXA10-2 LOC748850 LOC748850 TULP3 TULP3 LRP5 LRP5 TBX5 TBX5 ENSPTRP00000069764 ENSPTRP00000069764 IQCE IQCE IMPAD1 IMPAD1 MYH3 MYH3 LOC100614251 LOC100614251 CREBBP CREBBP FGF8 FGF8 SHH SHH NOTCH2 NOTCH2 HDAC1 HDAC1 SALL4 SALL4 BCL2L11 BCL2L11 ENSPTRP00000077262 ENSPTRP00000077262 FBXW4 FBXW4 TFAP2B TFAP2B DYNC2H1 DYNC2H1 WNT3-2 WNT3-2 ENSPTRP00000078515 ENSPTRP00000078515 HOXD9 HOXD9 SP9 SP9 LEF1 LEF1 CYP26B1 CYP26B1 BMP4-2 BMP4-2 LRP4 LRP4 ACD ACD RARB RARB RARG RARG ALX4 ALX4 FGF10 FGF10 MBNL1 MBNL1 HNF1A HNF1A TBX3 TBX3 WNT5A WNT5A TFAP2A TFAP2A ATRX ATRX PTCH1 PTCH1 ECE1 ECE1 SOX11 SOX11 FBN2 FBN2 SHOX2 SHOX2 CHST11 CHST11 BAX BAX ZNF219 ZNF219 TBC1D32 TBC1D32 OSR2 OSR2 DKK1 DKK1 BMPR1A BMPR1A FGFR2 FGFR2 FGF4 FGF4 ZBTB16 ZBTB16 CACNA1C CACNA1C HOXC11 HOXC11 HOXC10 HOXC10 FGF9 FGF9 FREM2 FREM2 BMP4 BMP4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
IFT140Intraflagellar transport 140 homolog. (1471 aa)
RPGRIP1LRPGRIP1L isoform 4. (1269 aa)
TMEM107Transmembrane protein 107. (146 aa)
B9D1B9 domain containing 1. (204 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1581 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
MKS1MKS transition zone complex subunit 1. (559 aa)
SKIV-ski sarcoma viral oncogene homolog (Avian). (736 aa)
ALX3ALX homeobox 3. (343 aa)
CRABP2Cellular retinoic acid binding protein 2; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (138 aa)
PRRX1Paired related homeobox 1. (245 aa)
PLXNA2PLXNA2 isoform 1. (1909 aa)
FLVCR1Feline leukemia virus subgroup C cellular receptor 1. (569 aa)
TBX2T-box transcription factor 2. (712 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
TBX4TBX4 isoform 1. (545 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
RNF165Ring finger protein 165. (346 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
MEGF8Multiple EGF like domains 8. (2842 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
PKDCCPKDCC isoform 1. (461 aa)
AFF3AFF3 isoform 5. (1233 aa)
MAP3K20Sterile alpha motif and leucine zipper containing kinase AZK. (803 aa)
LNPKLunapark, ER junction formation factor. (459 aa)
EVX2Even-skipped homeobox 2. (476 aa)
HOXD13HOXD13 isoform 1. (344 aa)
HOXD10Homeobox protein Hox-D10; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Abd-B homeobox family. (410 aa)
COL3A1Collagen type III alpha 1 chain. (1466 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
GDF5GDF5 isoform 1. (501 aa)
IFT52Intraflagellar transport 52 homolog. (437 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
ZNF141Zinc finger protein 141. (474 aa)
WDR19WD repeat domain 19. (1342 aa)
INTUInturned planar cell polarity effector homolog. (911 aa)
SFRP2Secreted frizzled-related protein 2. (295 aa)
CPLANE1Ciliogenesis and planar polarity effector 1. (3197 aa)
PITX1Homeobox protein. (314 aa)
PBX2Pre-B-cell leukemia homeobox 2. (430 aa)
GNA12Guanine nucleotide binding protein (G protein) alpha 12. (381 aa)
HOXA11HOXA11 isoform 2. (313 aa)
GLI3Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa)
SEMA3CSEMA3C isoform 1; Belongs to the semaphorin family. (751 aa)
DLX5Distal-less homeobox 5. (289 aa)
CHD7CHD7 isoform 1. (2997 aa)
RDH10Retinol dehydrogenase 10 (All-trans); Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
GRHL2Grainyhead like transcription factor 2. (625 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
RECKReversion-inducing-cysteine-rich protein with kazal motifs. (965 aa)
PCSK5PCSK5 isoform 1; Belongs to the peptidase S8 family. (1860 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
LMBR1LMBR1 isoform 7; Belongs to the LIMR family. (531 aa)
COL2A1Collagen type II alpha 1 chain. (1487 aa)
FZD6Frizzled homolog 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa)
WDPCPWDPCP isoform 2. (746 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
FRAS1Fraser extracellular matrix complex subunit 1. (4012 aa)
HOXA13-2HOXA13 isoform 1. (388 aa)
TWIST1TWIST1 isoform 2. (163 aa)
NIPBLNipped-B protein. (2804 aa)
ZNF358Zinc finger protein 358. (559 aa)
EN1Homeobox protein engrailed-like. (396 aa)
HDAC2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (581 aa)
BAK1BCL2-antagonist/killer 1. (211 aa)
SOX4Transcription factor SOX. (474 aa)
HAND2Heart and neural crest derivatives expressed 2. (217 aa)
ASPHASPH isoform 1. (762 aa)
TMEM231T0150531 isoform 1. (345 aa)
MSX1Homeobox protein MSX-1; Acts as a transcriptional repressor. May play a role in limb- pattern formation. Acts in cranofacial development and specifically in odontogenesis (By similarity). (303 aa)
SP8Sp8 transcription factor. (507 aa)
DLX6DLX6 isoform 1. (295 aa)
HOXD12HOXD12 isoform 1. (270 aa)
PBX1Pre-B-cell leukemia homeobox 1. (486 aa)
LOC104003639Guanine nucleotide-binding protein G(s) subunit alpha. (245 aa)
HOXA13Homeobox A13. (388 aa)
C2CD3C2CD3 isoform 3. (2298 aa)
FMN1FMN1 isoform 1. (1425 aa)
RSPO2R-spondin 2 homolog. (243 aa)
ENSPTRP00000064416annotation not available (502 aa)
SALL1SALL1 isoform 2. (1326 aa)
WNT7AProtein Wnt-7a; Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta- catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes. Required for normal [...] (349 aa)
RUNX2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (569 aa)
ZIC3Zic family member 3. (466 aa)
HOXA10HOXA10 isoform 2. (410 aa)
TMEM107-2Transmembrane protein 107. (140 aa)
ENSPTRP00000066776annotation not available (570 aa)
HOXA10-2Homeobox A10. (410 aa)
LOC748850HDAC2 isoform 9. (445 aa)
TULP3TULP3 isoform 3; Belongs to the TUB family. (501 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1606 aa)
TBX5T-box transcription factor 5. (518 aa)
ENSPTRP00000069764annotation not available (1213 aa)
IQCEIQCE isoform 2. (841 aa)
IMPAD1Inositol monophosphatase domain containing 1. (388 aa)
MYH3Myosin, heavy chain 3, skeletal muscle, embryonic; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1940 aa)
LOC100614251F-box/WD repeat-containing protein 4 pseudogene. (342 aa)
CREBBPCREB binding protein. (2442 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
NOTCH2NOTCH2 isoform 1. (2612 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
SALL4SALL4 isoform 1. (1053 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
ENSPTRP00000077262annotation not available (314 aa)
FBXW4F-box and WD repeat domain containing 4. (412 aa)
TFAP2BTranscription factor AP-2 beta. (467 aa)
DYNC2H1DYNC2H1 isoform 4. (4314 aa)
WNT3-2Wnt family member 3. (290 aa)
ENSPTRP00000078515annotation not available (198 aa)
HOXD9HOXD9 isoform 1. (356 aa)
SP9Sp9 transcription factor. (481 aa)
LEF1Lymphoid enhancer binding factor 1. (414 aa)
CYP26B1Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
LRP4Low density lipoprotein receptor-related protein 4. (1906 aa)
ACDACD isoform 1. (458 aa)
RARBRetinoic acid receptor, beta. (448 aa)
RARGRetinoic acid receptor, gamma. (456 aa)
ALX4ALX homeobox 4. (411 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
MBNL1Muscleblind like splicing regulator 1. (400 aa)
HNF1AHNF1 homeobox A. (662 aa)
TBX3T-box transcription factor 3. (743 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
TFAP2ATranscription factor AP-2 alpha. (439 aa)
ATRXTranscriptional regulator ATRX; Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase a [...] (2492 aa)
PTCH1PTCH1 isoform 8. (1428 aa)
ECE1Endothelin converting enzyme 1. (770 aa)
SOX11Transcription factor SOX. (441 aa)
FBN2FBN2 isoform 1. (2912 aa)
SHOX2SHOX2 isoform 2. (343 aa)
CHST11Carbohydrate sulfotransferase. (352 aa)
BAXBAX isoform 7. (123 aa)
ZNF219Zinc finger protein 219. (722 aa)
TBC1D32TBC1D32 isoform 4. (1298 aa)
OSR2Protein odd-skipped-related 2 isoform X4. (433 aa)
DKK1Dickkopf-like protein 1. (289 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
ZBTB16Zinc finger and BTB domain containing 16. (673 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2186 aa)
HOXC11HOXC11 isoform 1. (304 aa)
HOXC10Homeobox protein Hox-C10. (342 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FREM2FRAS1 related extracellular matrix 2. (3169 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.