STRINGSTRING
OSR2 OSR2 ALX3 ALX3 CRABP2 CRABP2 ZBTB16 ZBTB16 CACNA1C CACNA1C ALDH1A2 ALDH1A2 RPGRIP1L RPGRIP1L WNT3 WNT3 RNF165 RNF165 OSR1 OSR1 LNPK LNPK HOXD10 HOXD10 GDF5 GDF5 TP63 TP63 HOXA11 HOXA11 RDH10 RDH10 RECK RECK CTNNB1 CTNNB1 HOXA13-2 HOXA13-2 TWIST1 TWIST1 NIPBL NIPBL ZNF358 ZNF358 EN1 EN1 MSX1 MSX1 HOXA13 HOXA13 FMN1 FMN1 RSPO2 RSPO2 WNT7A WNT7A RUNX2 RUNX2 TBX5 TBX5 SHH SHH ENSPTRP00000077262 ENSPTRP00000077262 TFAP2B TFAP2B WNT3-2 WNT3-2 HOXD9 HOXD9 ALX4 ALX4 TBX3 TBX3 TFAP2A TFAP2A ATRX ATRX SHOX2 SHOX2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
OSR2Protein odd-skipped-related 2 isoform X4. (433 aa)
ALX3ALX homeobox 3. (343 aa)
CRABP2Cellular retinoic acid binding protein 2; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (138 aa)
ZBTB16Zinc finger and BTB domain containing 16. (673 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2186 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
RPGRIP1LRPGRIP1L isoform 4. (1269 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
RNF165Ring finger protein 165. (346 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
LNPKLunapark, ER junction formation factor. (459 aa)
HOXD10Homeobox protein Hox-D10; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Abd-B homeobox family. (410 aa)
GDF5GDF5 isoform 1. (501 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
HOXA11HOXA11 isoform 2. (313 aa)
RDH10Retinol dehydrogenase 10 (All-trans); Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
RECKReversion-inducing-cysteine-rich protein with kazal motifs. (965 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
HOXA13-2HOXA13 isoform 1. (388 aa)
TWIST1TWIST1 isoform 2. (163 aa)
NIPBLNipped-B protein. (2804 aa)
ZNF358Zinc finger protein 358. (559 aa)
EN1Homeobox protein engrailed-like. (396 aa)
MSX1Homeobox protein MSX-1; Acts as a transcriptional repressor. May play a role in limb- pattern formation. Acts in cranofacial development and specifically in odontogenesis (By similarity). (303 aa)
HOXA13Homeobox A13. (388 aa)
FMN1FMN1 isoform 1. (1425 aa)
RSPO2R-spondin 2 homolog. (243 aa)
WNT7AProtein Wnt-7a; Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta- catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes. Required for normal [...] (349 aa)
RUNX2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (569 aa)
TBX5T-box transcription factor 5. (518 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
ENSPTRP00000077262annotation not available (314 aa)
TFAP2BTranscription factor AP-2 beta. (467 aa)
WNT3-2Wnt family member 3. (290 aa)
HOXD9HOXD9 isoform 1. (356 aa)
ALX4ALX homeobox 4. (411 aa)
TBX3T-box transcription factor 3. (743 aa)
TFAP2ATranscription factor AP-2 alpha. (439 aa)
ATRXTranscriptional regulator ATRX; Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase a [...] (2492 aa)
SHOX2SHOX2 isoform 2. (343 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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