STRINGSTRING
ENSPTRP00000063809 ENSPTRP00000063809 PHACTR4 PHACTR4 GATA3 GATA3 ENSPTRP00000065244 ENSPTRP00000065244 LUZP1 LUZP1 ENSPTRP00000066737 ENSPTRP00000066737 ATOH8 ATOH8 TULP3 TULP3 LOC459002 LOC459002 SIX1 SIX1 ENSPTRP00000070303 ENSPTRP00000070303 BCAS3 BCAS3 IFT172 IFT172 PAX2 PAX2 ENSPTRP00000093474 ENSPTRP00000093474 MIB1 MIB1 ENSPTRP00000091667 ENSPTRP00000091667 OVOL2 OVOL2 VEGFA VEGFA FZD1-2 FZD1-2 SCRIB-2 SCRIB-2 SOX11 SOX11 ST14 ST14 ENSPTRP00000089747 ENSPTRP00000089747 BRD2 BRD2 VASP VASP ENSPTRP00000088582 ENSPTRP00000088582 PRICKLE1 PRICKLE1 FZD1 FZD1 PTCH1 PTCH1 PTK7 PTK7 CLUAP1 CLUAP1 WNT5A WNT5A PAX8 PAX8 SHROOM3 SHROOM3 MED12 MED12 STIL STIL TMED2 TMED2 TEAD2 TEAD2 FGF10 FGF10 SDC4 SDC4 RARG RARG ITGB1BP1 ITGB1BP1 GRHL3 GRHL3 COBL COBL ENSPTRP00000082302 ENSPTRP00000082302 ENSPTRP00000081955 ENSPTRP00000081955 CITED2 CITED2 STK3 STK3 BMP4-2 BMP4-2 HES5-2 HES5-2 HOXA1-2 HOXA1-2 WNT6 WNT6 HS2ST1 HS2ST1 ENSPTRP00000078649 ENSPTRP00000078649 CECR2 CECR2 CK820_G0021556 CK820_G0021556 LOC100611246 LOC100611246 OPA1 OPA1 PLXNB2 PLXNB2 BCL2L11 BCL2L11 WNT9B-2 WNT9B-2 SALL4 SALL4 SHH SHH FGF8 FGF8 SKI SKI MTHFR MTHFR BCL10 BCL10 LMO4 LMO4 GLMN GLMN VANGL2 VANGL2 TGFB2 TGFB2 SDCCAG8 SDCCAG8 RET RET NODAL NODAL FGFR2 FGFR2 ADM ADM TRAF6 TRAF6 FOLR1 FOLR1 CEP290 CEP290 KDM2B KDM2B BMP4 BMP4 HIF1A HIF1A MTHFD1 MTHFD1 SPINT1 SPINT1 SOX8 SOX8 IRX3 IRX3 PFN1 PFN1 DVL2 DVL2 TCAP TCAP KAT2A KAT2A FZD2 FZD2 NOG NOG MKS1 MKS1 SOX9 SOX9 PRKACA PRKACA TGFB1 TGFB1 FUZ FUZ RPS7 RPS7 OSR1 OSR1 SEMA4C SEMA4C EDAR EDAR LRP2 LRP2 TGM2 TGM2 IFT52 IFT52 BMP7 BMP7 SETD2 SETD2 HESX1 HESX1 IFT57 IFT57 IFT122 IFT122 DVL3 DVL3 LIAS LIAS SEC24B SEC24B SFRP2 SFRP2 IRX2 IRX2 IRX1 IRX1 HAND1 HAND1 LRRC1 LRRC1 BMP5 BMP5 MTHFD1L MTHFD1L TBXT TBXT HOXA1 HOXA1 RALA RALA DLC1 DLC1 FZD3 FZD3 GRHL2 GRHL2 CTHRC1 CTHRC1 LHX2 LHX2 NOTCH1 NOTCH1 EDA EDA HES5 HES5 PRKACB PRKACB APAF1 APAF1 TSC2 TSC2 FZD6 FZD6 CTNNB1 CTNNB1 KIF20B KIF20B TWIST1 TWIST1 GDNF GDNF SOX4 SOX4 PROX1 PROX1 TRIM71 TRIM71 RARA RARA SFRP1 SFRP1 CASP3 CASP3 ENSPTRP00000055426 ENSPTRP00000055426 TCTN1 TCTN1 DAB2IP DAB2IP BBS4 BBS4 HECTD1 HECTD1 NFIB NFIB CELSR1 CELSR1 WNT9B WNT9B CK820_G0012168 CK820_G0012168 SCRIB SCRIB RGMA RGMA ARHGAP35 ARHGAP35 ENSPTRP00000074987 ENSPTRP00000074987 KDM6A KDM6A CDK20 CDK20 YWHAZ YWHAZ CK820_G0042370 CK820_G0042370 ENSPTRP00000074059 ENSPTRP00000074059 SUFU SUFU DVL1 DVL1 PODXL PODXL ABL1 ABL1 DEAF1 DEAF1 CC2D2A CC2D2A STK4 STK4 WNT4 WNT4 ENSPTRP00000063424 ENSPTRP00000063424 LOC735645 LOC735645 SHANK3 SHANK3 TSC1 TSC1
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSPTRP00000063809annotation not available (177 aa)
PHACTR4Phosphatase and actin regulator. (712 aa)
GATA3GATA binding protein 3. (444 aa)
ENSPTRP00000065244annotation not available (463 aa)
LUZP1Leucine zipper protein 1. (1076 aa)
ENSPTRP00000066737annotation not available (186 aa)
ATOH8Atonal bHLH transcription factor 8. (323 aa)
TULP3TULP3 isoform 3; Belongs to the TUB family. (501 aa)
LOC45900240S ribosomal protein S7 pseudogene. (189 aa)
SIX1SIX homeobox 1. (284 aa)
ENSPTRP00000070303annotation not available (117 aa)
BCAS3BCAS3 microtubule associated cell migration factor. (950 aa)
IFT172Intraflagellar transport 172 homolog. (1767 aa)
PAX2PAX2 isoform 1. (417 aa)
ENSPTRP00000093474Cadherin EGF LAG seven-pass G-type receptor 1. (124 aa)
MIB1Mindbomb E3 ubiquitin protein ligase 1. (1014 aa)
ENSPTRP00000091667annotation not available (191 aa)
OVOL2Ovo like zinc finger 2. (275 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (395 aa)
FZD1-2Frizzled class receptor 1. (580 aa)
SCRIB-2Scribbled homolog. (1662 aa)
SOX11Transcription factor SOX. (441 aa)
ST14Suppressor of tumorigenicity 14 protein homolog; Degrades extracellular matrix. Belongs to the peptidase S1 family. (862 aa)
ENSPTRP00000089747annotation not available (156 aa)
BRD2Bromodomain containing 2. (835 aa)
VASPVasodilator-stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (380 aa)
ENSPTRP00000088582annotation not available (66 aa)
PRICKLE1PRICKLE1 isoform 11. (831 aa)
FZD1FZD1 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (580 aa)
PTCH1PTCH1 isoform 8. (1428 aa)
PTK7Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1078 aa)
CLUAP1CLUAP1 isoform 5. (432 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
PAX8PAX8 isoform 1. (456 aa)
SHROOM3SHROOM3 isoform 1. (1945 aa)
MED12Mediator of RNA polymerase II transcription subunit 12; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifi [...] (2182 aa)
STILSTIL centriolar assembly protein. (1288 aa)
TMED2Transmembrane emp24 domain trafficking protein 2. (208 aa)
TEAD2TEA domain transcription factor 2. (451 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
SDC4Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (198 aa)
RARGRetinoic acid receptor, gamma. (456 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (200 aa)
GRHL3Grainyhead like transcription factor 3. (626 aa)
COBLCordon-bleu WH2 repeat protein. (1333 aa)
ENSPTRP00000082302annotation not available (814 aa)
ENSPTRP00000081955annotation not available (66 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
STK3Serine/threonine kinase 3. (519 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
HES5-2Hes family bHLH transcription factor 5. (165 aa)
HOXA1-2Homeobox A1. (335 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
HS2ST1T0142978 isoform 1. (356 aa)
ENSPTRP00000078649annotation not available (188 aa)
CECR2CECR2 isoform 2. (1485 aa)
CK820_G0021556TMED2 isoform 3. (200 aa)
LOC10061124614-3-3 protein zeta/delta pseudogene. (212 aa)
OPA1OPA1 mitochondrial dynamin like GTPase; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (1015 aa)
PLXNB2PLXNB2 isoform 1. (1838 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
WNT9B-2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
SALL4SALL4 isoform 1. (1053 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
SKIV-ski sarcoma viral oncogene homolog (Avian). (736 aa)
MTHFRMethylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (656 aa)
BCL10B-cell CLL/lymphoma 10. (316 aa)
LMO4LIM domain only 4. (165 aa)
GLMNGlomulin, FKBP associated protein. (594 aa)
VANGL2Vang-like protein. (521 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
SDCCAG8Serologically defined colon cancer antigen 8. (713 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1116 aa)
NODALNODAL isoform 2. (347 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
ADMAdrenomedullin. (185 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
FOLR1Folate receptor alpha. (257 aa)
CEP290CEP290 isoform 5. (2454 aa)
KDM2BLysine (K)-specific demethylase 2B. (1336 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
MTHFD1MTHFD1 isoform 1. (1020 aa)
SPINT1SPINT1 isoform 2. (529 aa)
SOX8SOX8 isoform 1. (446 aa)
IRX3Iroquois homeobox 3. (500 aa)
PFN1Profilin; Belongs to the profilin family. (140 aa)
DVL2Dishevelled segment polarity protein 2. (736 aa)
TCAPTCAP isoform 1. (167 aa)
KAT2AHistone acetyltransferase KAT2A isoform X1. (837 aa)
FZD2FZD2 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (548 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
MKS1MKS transition zone complex subunit 1. (559 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
PRKACAPRKACA isoform 7; Belongs to the protein kinase superfamily. (289 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
FUZFuzzy planar cell polarity protein. (418 aa)
RPS740S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (194 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
SEMA4CSEMA4C isoform 2; Belongs to the semaphorin family. (833 aa)
EDAREctodysplasin A receptor. (496 aa)
LRP2LRP2 isoform 1. (4655 aa)
TGM2Transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase). (687 aa)
IFT52Intraflagellar transport 52 homolog. (437 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
SETD2SET domain containing 2, histone lysine methyltransferase. (2564 aa)
HESX1Homeobox expressed in ES cells 1; Required for the normal development of the forebrain, eyes and other anterior structures such as the olfactory placodes and pituitary gland. Possible transcriptional repressor. Binds to the palindromic PIII sequence, 5'-AGCTTGAGTCTAATTGAATTAACTGTAC-3'. HESX1 and PROP1 bind as heterodimers on this palindromic site, and, in vitro, HESX1 can antagonize PROP1 activation (By similarity). (185 aa)
IFT57Intraflagellar transport 57 homolog. (429 aa)
IFT122IFT122 isoform 10. (1286 aa)
DVL3Dishevelled segment polarity protein 3. (716 aa)
LIASLipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (372 aa)
SEC24BSEC24B isoform 1. (1286 aa)
SFRP2Secreted frizzled-related protein 2. (295 aa)
IRX2Iroquois homeobox 2. (471 aa)
IRX1Iroquois homeobox 1. (480 aa)
HAND1Heart and neural crest derivatives expressed 1. (215 aa)
LRRC1Leucine rich repeat containing 1. (524 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
MTHFD1LMethylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like. (805 aa)
TBXTT-box transcription factor T. (435 aa)
HOXA1HOXA1 isoform 2. (335 aa)
RALAV-ral simian leukemia viral oncogene homolog A (Ras related). (206 aa)
DLC1DLC1 Rho GTPase activating protein. (1528 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
GRHL2Grainyhead like transcription factor 2. (625 aa)
CTHRC1Collagen triple helix repeat containing 1. (243 aa)
LHX2LHX2 isoform 1. (406 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
EDAEctodysplasin A; Belongs to the tumor necrosis factor family. (391 aa)
HES5Hes family bHLH transcription factor 5. (165 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
TSC2Tuberous sclerosis 2. (1689 aa)
FZD6Frizzled homolog 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
KIF20BKIF20B isoform 2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1822 aa)
TWIST1TWIST1 isoform 2. (163 aa)
GDNFGlial cell derived neurotrophic factor. (228 aa)
SOX4Transcription factor SOX. (474 aa)
PROX1Prospero homeobox 1. (737 aa)
TRIM71Tripartite motif containing 71. (868 aa)
RARARARA isoform 4. (624 aa)
SFRP1Secreted frizzled-related protein 1. (314 aa)
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. (277 aa)
ENSPTRP00000055426annotation not available (200 aa)
TCTN1Tectonic family member 1. (592 aa)
DAB2IPDAB2 interacting protein. (1189 aa)
BBS4Bardet-Biedl syndrome 4. (519 aa)
HECTD1HECT domain E3 ubiquitin protein ligase 1. (2610 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (570 aa)
CELSR1CELSR1 isoform 1; Belongs to the G-protein coupled receptor 2 family. (2998 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
CK820_G0012168ABL1 isoform 3. (1149 aa)
SCRIBSCRIB isoform 8. (959 aa)
RGMARepulsive guidance molecule BMP co-receptor a. (458 aa)
ARHGAP35Glucocorticoid receptor DNA binding factor 1. (1519 aa)
ENSPTRP00000074987annotation not available (189 aa)
KDM6AKDM6A isoform 1. (1453 aa)
CDK20Cyclin-dependent kinase 20; Belongs to the protein kinase superfamily. (376 aa)
YWHAZTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide; Belongs to the 14-3-3 family. (245 aa)
CK820_G0042370TEAD2 isoform 6. (427 aa)
ENSPTRP00000074059annotation not available (180 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (519 aa)
DVL1Segment polarity protein dishevelled homolog DVL-1; Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) (By simi [...] (743 aa)
PODXLPodocalyxin; Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Belongs to the podocalyxin family. (556 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
DEAF1Deformed epidermal autoregulatory factor 1 homolog; Transcription factor that binds to sequence with multiple copies of 5'-TTC[CG]G-3' present in its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid response element (RARE) 5'-AGGGTTCACCGAAAGTTCA-3'. Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction. Regulates epithelial cell proliferation and side-branching in the mammary gland. Required for neural tube closure and skeletal patterning. Controls the expressio [...] (537 aa)
CC2D2ACC2D2A isoform 1. (1627 aa)
STK4Serine/threonine-protein kinase 4. (487 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
ENSPTRP00000063424annotation not available (1563 aa)
LOC73564540S ribosomal protein S7 pseudogene. (177 aa)
SHANK3SHANK3 isoform 2. (1744 aa)
TSC1TSC complex subunit 1. (1164 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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