(34 nodes) miRNA-mediated gene silencing network (Pan troglodytes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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Your Input:
	AGO1	Eukaryotic translation initiation factor 2C, 1; Belongs to the argonaute family. (860 aa)
	AGO3	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (860 aa)
	MOV10	Mov10, Moloney leukemia virus 10, homolog. (1005 aa)
	CNOT1	CCR4-NOT transcription complex, subunit 1. (2383 aa)
	WTIP	WT1 interacting protein. (428 aa)
	ZFP36	Zinc finger protein 36, C3H type, homolog. (332 aa)
	EIF6	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity. In tissues responsive to insulin, contro [...] (245 aa)
	LIMD1	LIM domains containing 1. (676 aa)
	EIF4G1	Eukaryotic translation initiation factor 4 gamma 1. (1559 aa)
	CNOT8	CCR4-NOT transcription complex, subunit 8. (292 aa)
	XPO5	XPO5 isoform 1. (1204 aa)
	AGO2	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (878 aa)
	EIF4ENIF1	Eukaryotic translation initiation factor 4E nuclear import factor 1. (985 aa)
	AGO4	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (861 aa)
	DDX6	DEAD (Asp-Glu-Ala-Asp) box polypeptide 6; Belongs to the DEAD box helicase family. (483 aa)
	TNRC6A	TNRC6A isoform 3. (1937 aa)
	TRIM71	Tripartite motif containing 71. (868 aa)
	AJUBA	LIM domain-containing protein ajuba isoform X1. (538 aa)
	CK820_G0038659	CNOT7 isoform 10. (245 aa)
	NCBP1	Nuclear cap binding protein subunit 1, 80kDa. (790 aa)
	CNOT6	CCR4-NOT transcription complex, subunit 6. (557 aa)
	ENSPTRP00000074149	annotation not available (212 aa)
	ENSPTRP00000076468	annotation not available (140 aa)
	CNOT7	CCR4-NOT transcription complex, subunit 7. (285 aa)
	NCBP2	Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...] (148 aa)
	RAN	GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family. (234 aa)
	TNRC6B	TNRC6B isoform 2. (1832 aa)
	ENSPTRP00000083112	annotation not available (413 aa)
	EIF4ENIF1-2	Eukaryotic translation initiation factor 4E nuclear import factor 1. (985 aa)
	TNRC6C	Trinucleotide repeat containing adaptor 6C. (1943 aa)
	ENSPTRP00000090981	annotation not available (244 aa)
	ENSPTRP00000091556	annotation not available (277 aa)
	ENSPTRP00000092190	annotation not available (433 aa)
	EIF4E2	Eukaryotic translation initiation factor 4E family member 2; Belongs to the eukaryotic initiation factor 4E family. (249 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGO1	AGO2	ENSPTRP00000081341	ENSPTRP00000035263	Eukaryotic translation initiation factor 2C, 1; Belongs to the argonaute family.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.996
AGO1	AGO3	ENSPTRP00000081341	ENSPTRP00000000933	Eukaryotic translation initiation factor 2C, 1; Belongs to the argonaute family.	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	0.938
AGO1	AGO4	ENSPTRP00000081341	ENSPTRP00000044180	Eukaryotic translation initiation factor 2C, 1; Belongs to the argonaute family.	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	0.885
AGO1	DDX6	ENSPTRP00000081341	ENSPTRP00000044660	Eukaryotic translation initiation factor 2C, 1; Belongs to the argonaute family.	DEAD (Asp-Glu-Ala-Asp) box polypeptide 6; Belongs to the DEAD box helicase family.	0.899
AGO1	EIF4G1	ENSPTRP00000081341	ENSPTRP00000026995	Eukaryotic translation initiation factor 2C, 1; Belongs to the argonaute family.	Eukaryotic translation initiation factor 4 gamma 1.	0.517
AGO1	ENSPTRP00000083112	ENSPTRP00000081341	ENSPTRP00000083112	Eukaryotic translation initiation factor 2C, 1; Belongs to the argonaute family.	annotation not available	0.699
AGO1	ENSPTRP00000092190	ENSPTRP00000081341	ENSPTRP00000092190	Eukaryotic translation initiation factor 2C, 1; Belongs to the argonaute family.	annotation not available	0.699
AGO1	LIMD1	ENSPTRP00000081341	ENSPTRP00000025578	Eukaryotic translation initiation factor 2C, 1; Belongs to the argonaute family.	LIM domains containing 1.	0.438
AGO1	MOV10	ENSPTRP00000081341	ENSPTRP00000001914	Eukaryotic translation initiation factor 2C, 1; Belongs to the argonaute family.	Mov10, Moloney leukemia virus 10, homolog.	0.913
AGO1	NCBP2	ENSPTRP00000081341	ENSPTRP00000080568	Eukaryotic translation initiation factor 2C, 1; Belongs to the argonaute family.	Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...]	0.443
AGO1	RAN	ENSPTRP00000081341	ENSPTRP00000081544	Eukaryotic translation initiation factor 2C, 1; Belongs to the argonaute family.	GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family.	0.410
AGO1	TNRC6A	ENSPTRP00000081341	ENSPTRP00000047103	Eukaryotic translation initiation factor 2C, 1; Belongs to the argonaute family.	TNRC6A isoform 3.	0.998
AGO1	TNRC6B	ENSPTRP00000081341	ENSPTRP00000081774	Eukaryotic translation initiation factor 2C, 1; Belongs to the argonaute family.	TNRC6B isoform 2.	0.961
AGO1	TNRC6C	ENSPTRP00000081341	ENSPTRP00000084787	Eukaryotic translation initiation factor 2C, 1; Belongs to the argonaute family.	Trinucleotide repeat containing adaptor 6C.	0.958
AGO1	XPO5	ENSPTRP00000081341	ENSPTRP00000031109	Eukaryotic translation initiation factor 2C, 1; Belongs to the argonaute family.	XPO5 isoform 1.	0.818
AGO1	ZFP36	ENSPTRP00000081341	ENSPTRP00000018802	Eukaryotic translation initiation factor 2C, 1; Belongs to the argonaute family.	Zinc finger protein 36, C3H type, homolog.	0.699
AGO2	AGO1	ENSPTRP00000035263	ENSPTRP00000081341	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Eukaryotic translation initiation factor 2C, 1; Belongs to the argonaute family.	0.996
AGO2	AGO3	ENSPTRP00000035263	ENSPTRP00000000933	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	0.979
AGO2	AGO4	ENSPTRP00000035263	ENSPTRP00000044180	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	0.937
AGO2	CNOT1	ENSPTRP00000035263	ENSPTRP00000013973	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	CCR4-NOT transcription complex, subunit 1.	0.738