STRINGSTRING
IL6R IL6R BMPR1A BMPR1A NKX6-2 NKX6-2 MEN1 MEN1 WNT11 WNT11 SIDT2 SIDT2 GDF11 GDF11 GSX1 GSX1 PDX1 PDX1 BMP4 BMP4 DUOX2 DUOX2 ALDH1A2 ALDH1A2 CDH1 CDH1 NF1 NF1 THRA THRA GIP GIP NOG NOG SOX9 SOX9 GATA6 GATA6 SMAD4 SMAD4 MAP2K2 MAP2K2 CYP1B1 CYP1B1 SIX3 SIX3 EIF2AK3 EIF2AK3 BMP2 BMP2 NKX2-2 NKX2-2 PAX1 PAX1 GHRH GHRH TBX1 TBX1 MAPK1 MAPK1 HESX1 HESX1 POU1F1 POU1F1 NKX6-1 NKX6-1 PITX2 PITX2 EDNRA EDNRA SLC6A3 SLC6A3 SRD5A1 SRD5A1 ISL1 ISL1 OTP OTP PCSK1 PCSK1 PITX1 PITX1 NR3C1 NR3C1 NKX2-5 NKX2-5 PROP1 PROP1 BMP6 BMP6 GCM2 GCM2 EDN1 EDN1 SRF SRF BMP5 BMP5 RFX6 RFX6 DLL1 DLL1 HOXA5 HOXA5 CDK6 CDK6 BHLHA15 BHLHA15 PAX4 PAX4 SMO SMO CRH CRH TG TG NR5A1 NR5A1 GLI2 GLI2 TSPO TSPO FOXE1 FOXE1 CRKL CRKL SOX2 SOX2 NR0B1 NR0B1 MNX1 MNX1 ANXA1 ANXA1 BAK1 BAK1 SOX4 SOX4 ARMC5 ARMC5 MAPK3 MAPK3 GATA2 GATA2 NEUROG3 NEUROG3 PBX1 PBX1 GIPR GIPR SMAD2 SMAD2 HOXB3 HOXB3 INSR INSR WNT4 WNT4 LHX3 LHX3 GHRHR GHRHR HES1 HES1 ENSPTRP00000064416 ENSPTRP00000064416 SALL1 SALL1 GATA3 GATA3 TBX19 TBX19 PAX6 PAX6 HOXA3 HOXA3 SMO-2 SMO-2 IL6 IL6 DRD2 DRD2 ENSPTRP00000069764 ENSPTRP00000069764 SIX1 SIX1 BHLHA15-2 BHLHA15-2 HOXA3-2 HOXA3-2 NKX2-1 NKX2-1 CREB1 CREB1 TGFBR1 TGFBR1 GHRHR-2 GHRHR-2 ONECUT1 ONECUT1 FGF8 FGF8 SHH SHH ASCL1 ASCL1 GLI1 GLI1 LOC107971060 LOC107971060 ENSPTRP00000078515 ENSPTRP00000078515 STRA6 STRA6 RBPJ RBPJ BRAF BRAF IL6-2 IL6-2 ENSPTRP00000080279 ENSPTRP00000080279 BMP4-2 BMP4-2 ONECUT2 ONECUT2 CITED2 CITED2 HNF1B HNF1B FGF10 FGF10 MDK MDK PAX8 PAX8 WNT5A WNT5A RFX3 RFX3 HOXD3 HOXD3 HNF4A HNF4A WT1 WT1 ARID5B ARID5B CGA CGA RAF1 RAF1 BRAF-2 BRAF-2 ENSPTRP00000089450 ENSPTRP00000089450 DKK3 DKK3 FOXA2 FOXA2 PDPK1 PDPK1 ENSPTRP00000090382 ENSPTRP00000090382 SMAD3 SMAD3 INHBB INHBB SOX3 SOX3 CDH2 CDH2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL6RInterleukin 6 receptor. (442 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
NKX6-2NKX6-2 isoform 1. (276 aa)
MEN1MEN1 isoform 14. (615 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
SIDT2SID1 transmembrane family member 2 isoform X7. (854 aa)
GDF11GDF11 isoform 1. (407 aa)
GSX1GSX1 isoform 1. (264 aa)
PDX1Pancreas/duodenum homeobox protein 1; Activates insulin and somatostatin gene transcription. Key regulator of islet peptide hormone expression but also responsible for the development of the pancreas, most probably by determining maturation and differentiation of common pancreatic precursor cells in the developing gut. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element [...] (283 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
DUOX2DUOX2 isoform 1. (1548 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
CDH1CDH1 isoform 1; Cadherins are calcium-dependent cell adhesion proteins. (882 aa)
NF1Neurofibromin 1. (2839 aa)
THRAThyroid hormone receptor, alpha (Erythroblastic leukemia viral (V-erb-a) oncogene homolog, avian). (617 aa)
GIPGastric inhibitory polypeptide. (153 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
GATA6GATA binding protein 6. (594 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
CYP1B1Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (543 aa)
SIX3SIX homeobox 3. (331 aa)
EIF2AK3Eukaryotic translation initiation factor 2-alpha kinase 3. (1116 aa)
BMP2Bone morphogenetic protein 2. (398 aa)
NKX2-2NKX2-2 isoform 1. (273 aa)
PAX1PAX1 isoform 1. (457 aa)
GHRHGrowth hormone releasing hormone. (108 aa)
TBX1TBX1 isoform 1. (478 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
HESX1Homeobox expressed in ES cells 1; Required for the normal development of the forebrain, eyes and other anterior structures such as the olfactory placodes and pituitary gland. Possible transcriptional repressor. Binds to the palindromic PIII sequence, 5'-AGCTTGAGTCTAATTGAATTAACTGTAC-3'. HESX1 and PROP1 bind as heterodimers on this palindromic site, and, in vitro, HESX1 can antagonize PROP1 activation (By similarity). (185 aa)
POU1F1POU domain protein. (317 aa)
NKX6-1NKX6-1 isoform 2. (367 aa)
PITX2Homeobox protein. (324 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
SLC6A3Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (620 aa)
SRD5A13-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (259 aa)
ISL1ISL LIM homeobox 1. (349 aa)
OTPOrthopedia homeobox. (325 aa)
PCSK1Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family. (753 aa)
PITX1Homeobox protein. (314 aa)
NR3C1NR3C1 isoform 5. (778 aa)
NKX2-5NKX2-5 isoform 1. (325 aa)
PROP1PROP paired-like homeobox 1. (226 aa)
BMP6Bone morphogenetic protein 6. (512 aa)
GCM2GCM2 isoform 1. (506 aa)
EDN1EDN1 isoform 1. (212 aa)
SRFSerum response factor (C-fos serum response element-binding transcription factor). (508 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
RFX6RFX6 isoform 1. (928 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
HOXA5HOXA5 isoform 1. (270 aa)
CDK6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
BHLHA15Basic helix-loop-helix family member a15. (189 aa)
PAX4PAX4 isoform 1. (351 aa)
SMOSMO isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
CRHCorticotropin releasing hormone. (196 aa)
TGTG isoform 3. (2766 aa)
NR5A1Nuclear receptor subfamily 5 group A member 1. (461 aa)
GLI2GLI family zinc finger 2. (1587 aa)
TSPOTranslocator protein. (169 aa)
FOXE1FOXE1 isoform 1. (371 aa)
CRKLV-crk sarcoma virus CT10 oncogene homolog (Avian)-like. (303 aa)
SOX2SRY-box transcription factor 2. (319 aa)
NR0B1Nuclear receptor subfamily 0 group B member 1; Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity). Belongs to the nuclear hormone receptor family. NR0 subfamily. (470 aa)
MNX1Motor neuron and pancreas homeobox 1. (398 aa)
ANXA1Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of Fthe formyl peptide receptors (By similarity). Contribu [...] (346 aa)
BAK1BCL2-antagonist/killer 1. (211 aa)
SOX4Transcription factor SOX. (474 aa)
ARMC5Armadillo repeat containing 5. (1030 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
GATA2GATA binding protein 2. (480 aa)
NEUROG3NEUROG3 isoform 1. (214 aa)
PBX1Pre-B-cell leukemia homeobox 1. (486 aa)
GIPRGastric inhibitory polypeptide receptor; Belongs to the G-protein coupled receptor 2 family. (466 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
HOXB3HOXB3 isoform 13. (431 aa)
INSRTyrosine-protein kinase receptor. (1408 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
LHX3LHX3 isoform 2. (402 aa)
GHRHRGrowth hormone releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family. (423 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
ENSPTRP00000064416annotation not available (502 aa)
SALL1SALL1 isoform 2. (1326 aa)
GATA3GATA binding protein 3. (444 aa)
TBX19T-box transcription factor 19. (448 aa)
PAX6PAX6 isoform 13. (436 aa)
HOXA3HOXA3 isoform 3. (443 aa)
SMO-2Smoothened, frizzled class receptor. (786 aa)
IL6Interleukin 6 (Interferon, beta 2). (234 aa)
DRD2D(2) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. (490 aa)
ENSPTRP00000069764annotation not available (1213 aa)
SIX1SIX homeobox 1. (284 aa)
BHLHA15-2Basic helix-loop-helix family member a15. (189 aa)
HOXA3-2Homeobox A3. (443 aa)
NKX2-1NKX2-1 isoform 1. (401 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
GHRHR-2Growth hormone-releasing hormone receptor isoform X1. (447 aa)
ONECUT1One cut domain family member. (465 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (232 aa)
GLI1GLI family zinc finger 1. (1106 aa)
LOC107971060SRD5A1 isoform 2. (141 aa)
ENSPTRP00000078515annotation not available (198 aa)
STRA6Stimulated by retinoic acid 6. (706 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (500 aa)
BRAFBRAF isoform 1; Belongs to the protein kinase superfamily. (767 aa)
IL6-2Interleukin 6. (234 aa)
ENSPTRP00000080279annotation not available (270 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
ONECUT2One cut domain family member. (504 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
HNF1BHNF1 homeobox B. (557 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
MDKMidkine (Neurite growth-promoting factor 2). (143 aa)
PAX8PAX8 isoform 1. (456 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
RFX3RFX3 isoform 4. (761 aa)
HOXD3HOXD3 isoform 3. (432 aa)
HNF4AHepatocyte nuclear factor 4 alpha. (474 aa)
WT1WT1 transcription factor. (514 aa)
ARID5BARID5B isoform 1. (1187 aa)
CGAGlycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (147 aa)
RAF1RAF1 isoform 2; Belongs to the protein kinase superfamily. (668 aa)
BRAF-2BRAF isoform 2. (766 aa)
ENSPTRP00000089450annotation not available (303 aa)
DKK3Dickkopf WNT signaling pathway inhibitor 3. (413 aa)
FOXA2FOXA2 isoform 1. (464 aa)
PDPK13-phosphoinositide dependent protein kinase-1. (542 aa)
ENSPTRP00000090382annotation not available (493 aa)
SMAD3Mothers against decapentaplegic homolog. (442 aa)
INHBBInhibin subunit beta B. (407 aa)
SOX3SRY-box transcription factor 3. (446 aa)
CDH2Cadherin 2, type 1, N-cadherin (Neuronal); Cadherins are calcium-dependent cell adhesion proteins. (914 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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