STRINGSTRING
SEMA3C SEMA3C SELENOH SELENOH PTF1A PTF1A FGF10 FGF10 LAMA1 LAMA1 PLXNA1 PLXNA1 LAMA5 LAMA5 RAB26 RAB26 TGFB2 TGFB2 IGSF3 IGSF3 DAG1 DAG1 BMP7 BMP7 TGM2 TGM2 TFCP2L1 TFCP2L1 EDAR EDAR TGFB1 TGFB1 TWSG1 TWSG1 SOX9 SOX9 ESRP2 ESRP2 FGF7 FGF7 TGFB3 TGFB3 SRP54 SRP54 PDX1 PDX1 CELA1 CELA1 FGFR2 FGFR2 NRP1 NRP1 EDA EDA SOX10 SOX10 NFIB NFIB INSR INSR FOXC1 FOXC1 PAX6 PAX6 CLCN2 CLCN2 EGFR EGFR TNF TNF WLS WLS FGF8 FGF8 SHH SHH IGF2 IGF2 NKX3-1 NKX3-1 POLB POLB PLXND1 PLXND1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SEMA3CSEMA3C isoform 1; Belongs to the semaphorin family. (751 aa)
SELENOHSelenoprotein H. (121 aa)
PTF1APancreas associated transcription factor 1a. (328 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
LAMA1Laminin subunit alpha 1. (3104 aa)
PLXNA1PLXNA1 isoform 1. (1915 aa)
LAMA5Laminin, alpha 5. (2203 aa)
RAB26RAB26 isoform 1. (247 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
IGSF3IGSF3 isoform 1. (1212 aa)
DAG1Dystroglycan 1 (Dystrophin-associated glycoprotein 1). (895 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
TGM2Transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase). (687 aa)
TFCP2L1Transcription factor CP2 like 1. (479 aa)
EDAREctodysplasin A receptor. (496 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (223 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
ESRP2Epithelial splicing regulatory protein 2. (717 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
SRP54Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Belongs to the GTP-binding SRP family. SRP54 subfamily. (504 aa)
PDX1Pancreas/duodenum homeobox protein 1; Activates insulin and somatostatin gene transcription. Key regulator of islet peptide hormone expression but also responsible for the development of the pancreas, most probably by determining maturation and differentiation of common pancreatic precursor cells in the developing gut. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element [...] (283 aa)
CELA1CELA1 isoform 1; Belongs to the peptidase S1 family. (258 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
EDAEctodysplasin A; Belongs to the tumor necrosis factor family. (391 aa)
SOX10SRY-box transcription factor 10. (466 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (570 aa)
INSRTyrosine-protein kinase receptor. (1408 aa)
FOXC1FOXC1 isoform 1. (550 aa)
PAX6PAX6 isoform 13. (436 aa)
CLCN2Chloride channel protein. (898 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
WLSWnt ligand secretion mediator. (543 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
IGF2Insulin like growth factor 2. (236 aa)
NKX3-1NKX3-1 isoform 1. (234 aa)
POLBDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa)
PLXND1PLXND1 isoform 1. (1925 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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