(27 nodes) Cellular response to interferon-beta network (Pan troglodytes)

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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Your Input:
	IFITM2	Interferon induced transmembrane protein 2. (132 aa)
	PNPT1	Polyribonucleotide nucleotidyltransferase 1. (784 aa)
	IRGM	Immunity-related GTPase M. (214 aa)
	CK820_G0040447	CAPN2 isoform 2; Belongs to the peptidase C2 family. (708 aa)
	HTRA2	HtrA serine peptidase 2. (458 aa)
	NDUFA13-2	NADH:ubiquinone oxidoreductase subunit A13. (150 aa)
	ENSPTRP00000068740	annotation not available (675 aa)
	NDUFA13	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in [...] (144 aa)
	IFI16	IFI16 isoform 4. (733 aa)
	TREX1	Three prime repair exonuclease 1. (369 aa)
	AIM2	Absent in melanoma 2. (343 aa)
	OAS1	Oligoadenylate synthetase 1 isoform p46. (442 aa)
	STING1	TMEM173 isoform 2. (379 aa)
	IFNB1	Interferon beta 1. (187 aa)
	IRF1	Interferon regulatory factor. (325 aa)
	TLR3	Toll-like receptor 3; Belongs to the Toll-like receptor family. (904 aa)
	UBE2G2	Ubiquitin conjugating enzyme E2 G2; Belongs to the ubiquitin-conjugating enzyme family. (165 aa)
	IRGC	Interferon-gamma-inducible GTPase IFGGE protein. (463 aa)
	CDC34	Cell division cycle 34 homolog; Belongs to the ubiquitin-conjugating enzyme family. (235 aa)
	ACOD1	ACOD1 isoform 1. (490 aa)
	PYHIN1	Pyrin and HIN domain family member 1. (483 aa)
	ENSPTRP00000092837	annotation not available (325 aa)
	CAPN2	Calpain 2, (M/II) large subunit; Belongs to the peptidase C2 family. (703 aa)
	STAT1	Signal transducer and activator of transcription. (758 aa)
	MNDA	Myeloid cell nuclear differentiation antigen. (407 aa)
	UBE2K	Ubiquitin-conjugating enzyme E2-25 kDa; Belongs to the ubiquitin-conjugating enzyme family. (200 aa)
	PYDC5	Pyrin domain-only protein 3. (113 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIM2	ENSPTRP00000092837	ENSPTRP00000051692	ENSPTRP00000092837	Absent in melanoma 2.	annotation not available	0.459
AIM2	IFI16	ENSPTRP00000051692	ENSPTRP00000065596	Absent in melanoma 2.	IFI16 isoform 4.	0.974
AIM2	IFNB1	ENSPTRP00000051692	ENSPTRP00000035597	Absent in melanoma 2.	Interferon beta 1.	0.557
AIM2	IRF1	ENSPTRP00000051692	ENSPTRP00000029459	Absent in melanoma 2.	Interferon regulatory factor.	0.459
AIM2	MNDA	ENSPTRP00000051692	ENSPTRP00000089964	Absent in melanoma 2.	Myeloid cell nuclear differentiation antigen.	0.446
AIM2	PYDC5	ENSPTRP00000051692	ENSPTRP00000086456	Absent in melanoma 2.	Pyrin domain-only protein 3.	0.900
AIM2	STAT1	ENSPTRP00000051692	ENSPTRP00000090934	Absent in melanoma 2.	Signal transducer and activator of transcription.	0.418
AIM2	STING1	ENSPTRP00000051692	ENSPTRP00000045233	Absent in melanoma 2.	TMEM173 isoform 2.	0.537
AIM2	TLR3	ENSPTRP00000051692	ENSPTRP00000028569	Absent in melanoma 2.	Toll-like receptor 3; Belongs to the Toll-like receptor family.	0.527
CDC34	UBE2G2	ENSPTRP00000017246	ENSPTRP00000024077	Cell division cycle 34 homolog; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin conjugating enzyme E2 G2; Belongs to the ubiquitin-conjugating enzyme family.	0.565
CDC34	UBE2K	ENSPTRP00000017246	ENSPTRP00000088110	Cell division cycle 34 homolog; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin-conjugating enzyme E2-25 kDa; Belongs to the ubiquitin-conjugating enzyme family.	0.624
ENSPTRP00000092837	AIM2	ENSPTRP00000092837	ENSPTRP00000051692	annotation not available	Absent in melanoma 2.	0.459
ENSPTRP00000092837	IFNB1	ENSPTRP00000092837	ENSPTRP00000035597	annotation not available	Interferon beta 1.	0.714
ENSPTRP00000092837	OAS1	ENSPTRP00000092837	ENSPTRP00000049897	annotation not available	Oligoadenylate synthetase 1 isoform p46.	0.471
ENSPTRP00000092837	STAT1	ENSPTRP00000092837	ENSPTRP00000090934	annotation not available	Signal transducer and activator of transcription.	0.978
ENSPTRP00000092837	STING1	ENSPTRP00000092837	ENSPTRP00000045233	annotation not available	TMEM173 isoform 2.	0.504
ENSPTRP00000092837	TLR3	ENSPTRP00000092837	ENSPTRP00000028569	annotation not available	Toll-like receptor 3; Belongs to the Toll-like receptor family.	0.656
HTRA2	NDUFA13	ENSPTRP00000073790	ENSPTRP00000068091	HtrA serine peptidase 2.	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in [...]	0.504
HTRA2	NDUFA13-2	ENSPTRP00000073790	ENSPTRP00000069748	HtrA serine peptidase 2.	NADH:ubiquinone oxidoreductase subunit A13.	0.402
IFI16	AIM2	ENSPTRP00000065596	ENSPTRP00000051692	IFI16 isoform 4.	Absent in melanoma 2.	0.974