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BNIP3 BNIP3 ZNF205-2 ZNF205-2 BBC3 BBC3 BCL2L11 BCL2L11 PPIF PPIF ATP5IF1 ATP5IF1 HEBP2 HEBP2 EYA2 EYA2 BAX BAX RHOT1 RHOT1 BBC3-2 BBC3-2 GZMB GZMB STPG1 STPG1 HIP1R HIP1R BLOC1S2 BLOC1S2 BID BID GSK3A GSK3A MAPK10 MAPK10 CHCHD10 CHCHD10 SLC9A1 SLC9A1 ATF2 ATF2 SPG7 SPG7 MOAP1 MOAP1 LOC471721 LOC471721 LOC100614689 LOC100614689 BAK1 BAK1 MAPK8 MAPK8 BNIP3L BNIP3L NMT1 NMT1 TP53 TP53 ZNF205 ZNF205 ENSPTRP00000078515 ENSPTRP00000078515 GSK3B GSK3B CHCHD10-2 CHCHD10-2 VDAC2 VDAC2 RHOT2 RHOT2 SIVA1 SIVA1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BNIP3BCL2 interacting protein 3. (259 aa)
ZNF205-2Zinc finger protein 205. (554 aa)
BBC3BCL2 binding component 3. (270 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
PPIFPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (207 aa)
ATP5IF1ATP synthase inhibitory factor subunit 1. (106 aa)
HEBP2Heme binding protein 2. (205 aa)
EYA2Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (538 aa)
BAXBAX isoform 7. (123 aa)
RHOT1Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family. (752 aa)
BBC3-2BCL2 binding component 3. (270 aa)
GZMBGZMB isoform 2; Belongs to the peptidase S1 family. (280 aa)
STPG1Sperm tail PG-rich repeat containing 1. (334 aa)
HIP1RHuntingtin interacting protein 1 related. (1068 aa)
BLOC1S2Biogenesis of lysosomal organelles complex-1, subunit 2. (142 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (241 aa)
GSK3AGlycogen synthase kinase 3 alpha. (483 aa)
MAPK10Mitogen-activated protein kinase. (551 aa)
CHCHD10Coiled-coil-helix-coiled-coil-helix domain containing 10. (149 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (815 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
SPG7Spastic paraplegia 7 (Pure and complicated autosomal recessive). (787 aa)
MOAP1Modulator of apoptosis 1. (351 aa)
LOC471721Voltage-dependent anion channel 2. (297 aa)
LOC100614689BCL2-related ovarian killer. (207 aa)
BAK1BCL2-antagonist/killer 1. (211 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
BNIP3LBCL2/adenovirus E1B 19kDa interacting protein 3-like. (219 aa)
NMT1Glycylpeptide N-tetradecanoyltransferase; Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins; Belongs to the NMT family. (496 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
ZNF205Zinc finger protein 205. (554 aa)
ENSPTRP00000078515annotation not available (198 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (481 aa)
CHCHD10-2Coiled-coil-helix-coiled-coil-helix domain containing 10. (93 aa)
VDAC2VDAC2 isoform 1. (260 aa)
RHOT2Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family. (619 aa)
SIVA1Apoptosis regulatory protein Siva; Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl- x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis. (175 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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