STRINGSTRING
EGR1 EGR1 HIVEP3 HIVEP3 KLHL41 KLHL41 SOX11 SOX11 HEYL HEYL VAX1 VAX1 SELENON SELENON ENSPTRP00000085831 ENSPTRP00000085831 GTF3C5 GTF3C5 KRAS KRAS EMD EMD CITED2 CITED2 FOS FOS SHH SHH ENSPTRP00000074929 ENSPTRP00000074929 MEF2D MEF2D SCX SCX ENSPTRP00000069878 ENSPTRP00000069878 CDON CDON KLF5 KLF5 ATF3 ATF3 WNT3A WNT3A MAFF MAFF PAX5 PAX5 HMG20B HMG20B KLHL40 KLHL40 MYOG MYOG SIX4 SIX4 NR4A1 NR4A1 NOTCH1 NOTCH1 MED20 MED20 LEMD2 LEMD2 MEGF10 MEGF10 ANKRD33B ANKRD33B SAP30 SAP30 PHOX2B PHOX2B EOMES EOMES MYLK2 MYLK2 SMYD1 SMYD1 FOXN2 FOXN2 HLF HLF ZNF689 ZNF689 NUPR1 NUPR1 SOX8 SOX8 COPS2 COPS2 ASB2 ASB2 RB1 RB1 MYF5 MYF5 MYF6 MYF6 ANKRD33 ANKRD33 BARX2 BARX2 BCL9L BCL9L MYOD1 MYOD1 ANKRD1 ANKRD1 EGR2 EGR2 BTG2 BTG2 BCL9 BCL9 DMRTA2 DMRTA2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa)
HIVEP3Human immunodeficiency virus type I enhancer binding protein 3. (2405 aa)
KLHL41Kelch repeat and BTB domain-containing protein 5/10. (606 aa)
SOX11Transcription factor SOX. (441 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (328 aa)
VAX1Ventral anterior homeobox 1. (334 aa)
SELENONT0161445 isoform 2. (581 aa)
ENSPTRP00000085831annotation not available (79 aa)
GTF3C5General transcription factor IIIC, polypeptide 5, 63kDa. (528 aa)
KRASV-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
EMDEMD isoform 1. (254 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
ENSPTRP00000074929annotation not available (367 aa)
MEF2DMyocyte enhancer factor 2D. (521 aa)
SCXScleraxis bHLH transcription factor. (201 aa)
ENSPTRP00000069878annotation not available (125 aa)
CDONCell adhesion associated, oncogene regulated. (1286 aa)
KLF5Kruppel-like factor 5 (Intestinal). (457 aa)
ATF3Activating transcription factor 3. (181 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
MAFFV-maf musculoaponeurotic fibrosarcoma oncogene homolog F (Avian). (164 aa)
PAX5PAX5 isoform 1. (391 aa)
HMG20BHigh mobility group 20B. (317 aa)
KLHL40Kelch like family member 40. (621 aa)
MYOGMYOG isoform 1. (249 aa)
SIX4SIX homeobox 4. (781 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (652 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
MED20Mediator of RNA polymerase II transcription subunit 20; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (212 aa)
LEMD2LEM domain containing 2. (503 aa)
MEGF10MEGF10 isoform 2. (1140 aa)
ANKRD33BANKRD33B isoform 1. (494 aa)
SAP30Sin3A-associated protein, 30kDa. (220 aa)
PHOX2BPaired like homeobox 2B. (314 aa)
EOMESEOMES isoform 2. (704 aa)
MYLK2MYLK2 isoform 1. (596 aa)
SMYD1SET and MYND domain containing 1. (490 aa)
FOXN2FOXN2 isoform 2. (431 aa)
HLFHLF transcription factor, PAR bZIP family member. (295 aa)
ZNF689Zinc finger protein 689. (500 aa)
NUPR1Nuclear protein 1, transcriptional regulator. (82 aa)
SOX8SOX8 isoform 1. (446 aa)
COPS2COP9 constitutive photomorphogenic homolog subunit 2. (450 aa)
ASB2Ankyrin repeat and SOCS box containing 2. (635 aa)
RB1RB transcriptional corepressor 1. (928 aa)
MYF5Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (255 aa)
MYF6Myogenic factor 6. (242 aa)
ANKRD33Ankyrin repeat domain 33. (452 aa)
BARX2BARX homeobox 2. (279 aa)
BCL9LB-cell CLL/lymphoma 9-like. (1499 aa)
MYOD1Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (320 aa)
ANKRD1Ankyrin repeat domain 1 (Cardiac muscle). (319 aa)
EGR2Early growth response 2. (476 aa)
BTG2BTG anti-proliferation factor 2. (158 aa)
BCL9BCL9 transcription coactivator. (1426 aa)
DMRTA2DMRT like family A2. (539 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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