(38 nodes) Endodermal cell differentiation network (Pan troglodytes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ITGB2	Integrin beta. (863 aa)
	NODAL	NODAL isoform 2. (347 aa)
	MMP8	Matrix metallopeptidase 8. (467 aa)
	ITGA5	ITGA5 isoform 2; Belongs to the integrin alpha chain family. (1098 aa)
	ITGA7	ITGA7 isoform 6; Belongs to the integrin alpha chain family. (1181 aa)
	MMP14	Matrix metallopeptidase 14. (582 aa)
	RTF1	Rtf1, Paf1/RNA polymerase II complex component, homolog. (710 aa)
	LEO1	Leo1, Paf1/RNA polymerase II complex component, homolog. (666 aa)
	MMP15	Matrix metallopeptidase 15. (669 aa)
	HSBP1	Heat shock factor binding protein 1. (76 aa)
	GRB2	Growth factor receptor-bound protein 2. (217 aa)
	GATA6	GATA binding protein 6. (594 aa)
	LAMA3	Laminin subunit alpha 3. (3333 aa)
	ITGA4	Integrin, alpha 4 (Antigen CD49D, alpha 4 subunit of VLA-4 receptor); Belongs to the integrin alpha chain family. (1032 aa)
	MMP9	Matrix metallopeptidase 9. (699 aa)
	EOMES	EOMES isoform 2. (704 aa)
	SETD2	SET domain containing 2, histone lysine methyltransferase. (2564 aa)
	COL7A1	Collagen type VII alpha 1 chain. (2944 aa)
	INHBA	Inhibin subunit beta A. (426 aa)
	COL12A1	Collagen type XII alpha 1 chain. (3063 aa)
	SOX17	SOX17 isoform 1. (416 aa)
	LAMB3	Laminin subunit beta 3. (1171 aa)
	CTR9	Ctr9, Paf1/RNA polymerase II complex component, homolog. (1173 aa)
	FN1	FN1 isoform 1. (2477 aa)
	CTNNB1	Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
	SOX2	SRY-box transcription factor 2. (319 aa)
	ITGAV	Integrin, alpha V (Vitronectin receptor, alpha polypeptide, antigen CD51); Belongs to the integrin alpha chain family. (1048 aa)
	ITGB5	Integrin beta; Belongs to the integrin beta chain family. (799 aa)
	HMGA2	High mobility group AT-hook 2. (147 aa)
	COL4A2	Collagen type IV alpha 2 chain. (1711 aa)
	COL8A1	Collagen type VIII alpha 1 chain. (744 aa)
	LAMB1	LAMB1 isoform 5. (1789 aa)
	MIXL1	Mix paired-like homeobox. (232 aa)
	PAF1	Paf1, RNA polymerase II associated factor, homolog. (533 aa)
	CK820_G0045089	RANBP3 isoform 23. (97 aa)
	MMP2	Matrix metallopeptidase 2. (660 aa)
	COL11A1	Collagen type XI alpha 1 chain. (1818 aa)
	CDC73	Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog. (531 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC73	CTNNB1	ENSPTRP00000090347	ENSPTRP00000044466	Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog.	Catenin (Cadherin-associated protein), beta 1, 88kDa.	0.907
CDC73	CTR9	ENSPTRP00000090347	ENSPTRP00000041382	Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog.	Ctr9, Paf1/RNA polymerase II complex component, homolog.	0.999
CDC73	LEO1	ENSPTRP00000090347	ENSPTRP00000012100	Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog.	Leo1, Paf1/RNA polymerase II complex component, homolog.	0.999
CDC73	PAF1	ENSPTRP00000090347	ENSPTRP00000081951	Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog.	Paf1, RNA polymerase II associated factor, homolog.	0.999
CDC73	RTF1	ENSPTRP00000090347	ENSPTRP00000011849	Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog.	Rtf1, Paf1/RNA polymerase II complex component, homolog.	0.998
CDC73	SETD2	ENSPTRP00000090347	ENSPTRP00000025629	Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog.	SET domain containing 2, histone lysine methyltransferase.	0.513
CK820_G0045089	CTNNB1	ENSPTRP00000084713	ENSPTRP00000044466	RANBP3 isoform 23.	Catenin (Cadherin-associated protein), beta 1, 88kDa.	0.484
CK820_G0045089	SOX2	ENSPTRP00000084713	ENSPTRP00000046752	RANBP3 isoform 23.	SRY-box transcription factor 2.	0.463
COL11A1	COL12A1	ENSPTRP00000088916	ENSPTRP00000031362	Collagen type XI alpha 1 chain.	Collagen type XII alpha 1 chain.	0.406
COL11A1	COL4A2	ENSPTRP00000088916	ENSPTRP00000058373	Collagen type XI alpha 1 chain.	Collagen type IV alpha 2 chain.	0.495
COL11A1	MMP9	ENSPTRP00000088916	ENSPTRP00000023334	Collagen type XI alpha 1 chain.	Matrix metallopeptidase 9.	0.509
COL12A1	COL11A1	ENSPTRP00000031362	ENSPTRP00000088916	Collagen type XII alpha 1 chain.	Collagen type XI alpha 1 chain.	0.406
COL12A1	COL4A2	ENSPTRP00000031362	ENSPTRP00000058373	Collagen type XII alpha 1 chain.	Collagen type IV alpha 2 chain.	0.680
COL12A1	COL8A1	ENSPTRP00000031362	ENSPTRP00000058481	Collagen type XII alpha 1 chain.	Collagen type VIII alpha 1 chain.	0.418
COL12A1	LAMB3	ENSPTRP00000031362	ENSPTRP00000040144	Collagen type XII alpha 1 chain.	Laminin subunit beta 3.	0.407
COL12A1	MMP2	ENSPTRP00000031362	ENSPTRP00000087749	Collagen type XII alpha 1 chain.	Matrix metallopeptidase 2.	0.579
COL4A2	COL11A1	ENSPTRP00000058373	ENSPTRP00000088916	Collagen type IV alpha 2 chain.	Collagen type XI alpha 1 chain.	0.495
COL4A2	COL12A1	ENSPTRP00000058373	ENSPTRP00000031362	Collagen type IV alpha 2 chain.	Collagen type XII alpha 1 chain.	0.680
COL4A2	COL7A1	ENSPTRP00000058373	ENSPTRP00000025703	Collagen type IV alpha 2 chain.	Collagen type VII alpha 1 chain.	0.692
COL4A2	ITGA4	ENSPTRP00000058373	ENSPTRP00000021717	Collagen type IV alpha 2 chain.	Integrin, alpha 4 (Antigen CD49D, alpha 4 subunit of VLA-4 receptor); Belongs to the integrin alpha chain family.	0.721