(14 nodes) Nerve growth factor signaling pathway network (Pan troglodytes)

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second shell of interactors

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Your Input:
	NTRK1	Tyrosine-protein kinase receptor. (796 aa)
	SORT1	SORT1 isoform 2. (831 aa)
	CORO1A	Coronin; Belongs to the WD repeat coronin family. (461 aa)
	NKPD1	NTPase KAP family P-loop domain containing 1. (612 aa)
	NTF4	NTF4 isoform 1; Belongs to the NGF-beta family. (210 aa)
	KIDINS220	Kinase D interacting substrate 220. (1771 aa)
	MAGI2	Membrane associated guanylate kinase, WW and PDZ domain containing 2. (1283 aa)
	BDNF	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (329 aa)
	NGF	Beta-nerve growth factor; Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (By similarity). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone colla [...] (123 aa)
	RAPGEF1	RAPGEF1 isoform 5. (1065 aa)
	ENSPTRP00000076429	annotation not available (110 aa)
	RAPGEF2	RAPGEF2 isoform 2. (1701 aa)
	RAP1A	RAP1A, member of RAS oncogene family. (184 aa)
	NTF3	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (275 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BDNF	NGF	ENSPTRP00000060385	ENSPTRP00000070324	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Beta-nerve growth factor; Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (By similarity). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone colla [...]	0.736
BDNF	NTF3	ENSPTRP00000060385	ENSPTRP00000089931	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family.	0.709
BDNF	NTF4	ENSPTRP00000060385	ENSPTRP00000019336	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	NTF4 isoform 1; Belongs to the NGF-beta family.	0.977
BDNF	NTRK1	ENSPTRP00000060385	ENSPTRP00000083380	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Tyrosine-protein kinase receptor.	0.991
BDNF	SORT1	ENSPTRP00000060385	ENSPTRP00000001807	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	SORT1 isoform 2.	0.963
ENSPTRP00000076429	KIDINS220	ENSPTRP00000076429	ENSPTRP00000020003	annotation not available	Kinase D interacting substrate 220.	0.400
ENSPTRP00000076429	RAPGEF1	ENSPTRP00000076429	ENSPTRP00000074530	annotation not available	RAPGEF1 isoform 5.	0.795
ENSPTRP00000076429	RAPGEF2	ENSPTRP00000076429	ENSPTRP00000079253	annotation not available	RAPGEF2 isoform 2.	0.801
KIDINS220	ENSPTRP00000076429	ENSPTRP00000020003	ENSPTRP00000076429	Kinase D interacting substrate 220.	annotation not available	0.400
KIDINS220	MAGI2	ENSPTRP00000020003	ENSPTRP00000033085	Kinase D interacting substrate 220.	Membrane associated guanylate kinase, WW and PDZ domain containing 2.	0.697
KIDINS220	NGF	ENSPTRP00000020003	ENSPTRP00000070324	Kinase D interacting substrate 220.	Beta-nerve growth factor; Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (By similarity). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone colla [...]	0.552
KIDINS220	NTRK1	ENSPTRP00000020003	ENSPTRP00000083380	Kinase D interacting substrate 220.	Tyrosine-protein kinase receptor.	0.977
KIDINS220	RAP1A	ENSPTRP00000020003	ENSPTRP00000084644	Kinase D interacting substrate 220.	RAP1A, member of RAS oncogene family.	0.400
KIDINS220	RAPGEF1	ENSPTRP00000020003	ENSPTRP00000074530	Kinase D interacting substrate 220.	RAPGEF1 isoform 5.	0.409
MAGI2	KIDINS220	ENSPTRP00000033085	ENSPTRP00000020003	Membrane associated guanylate kinase, WW and PDZ domain containing 2.	Kinase D interacting substrate 220.	0.697
MAGI2	NKPD1	ENSPTRP00000033085	ENSPTRP00000019119	Membrane associated guanylate kinase, WW and PDZ domain containing 2.	NTPase KAP family P-loop domain containing 1.	0.510
MAGI2	RAPGEF2	ENSPTRP00000033085	ENSPTRP00000079253	Membrane associated guanylate kinase, WW and PDZ domain containing 2.	RAPGEF2 isoform 2.	0.968
NGF	BDNF	ENSPTRP00000070324	ENSPTRP00000060385	Beta-nerve growth factor; Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (By similarity). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone colla [...]	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	0.736
NGF	KIDINS220	ENSPTRP00000070324	ENSPTRP00000020003	Beta-nerve growth factor; Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (By similarity). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone colla [...]	Kinase D interacting substrate 220.	0.552
NGF	NTF4	ENSPTRP00000070324	ENSPTRP00000019336	Beta-nerve growth factor; Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (By similarity). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone colla [...]	NTF4 isoform 1; Belongs to the NGF-beta family.	0.714