(27 nodes) Pattern recognition receptor activity network (Pan troglodytes)

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Your Input:
	CLEC4E	C-type lectin domain family 4 member E. (219 aa)
	TRIM5	Tripartite motif-containing protein 5; Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1- UBE2N (als [...] (493 aa)
	NLRP6	NLR family pyrin domain containing 6. (892 aa)
	PGLYRP4	PGLYRP4 isoform 2. (373 aa)
	PGLYRP3	PGLYRP3 isoform 1. (341 aa)
	TNFAIP8L2	TNF alpha induced protein 8 like 2. (184 aa)
	PTAFR	Platelet activating factor receptor; Belongs to the G-protein coupled receptor 1 family. (342 aa)
	ENSPTRP00000088589	annotation not available (206 aa)
	TLR9	T0016681 isoform 1. (1033 aa)
	LY96	Lymphocyte antigen 96. (160 aa)
	SCARB1	SCARB1 isoform 8; Belongs to the CD36 family. (552 aa)
	COLEC12	Collectin sub-family member 12. (759 aa)
	CD36	CD36 molecule (Thrombospondin receptor); Belongs to the CD36 family. (472 aa)
	CD14	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (384 aa)
	CARD8	Caspase recruitment domain family member 8. (537 aa)
	TLR8	TLR8 isoform 2; Belongs to the Toll-like receptor family. (1059 aa)
	CLEC6A	C-type lectin domain family 6 member A. (208 aa)
	TLR7	Toll like receptor 7; Belongs to the Toll-like receptor family. (1049 aa)
	DMBT1	DMBT1 isoform 2. (2148 aa)
	TLR4	Toll-like receptor 4; Belongs to the Toll-like receptor family. (839 aa)
	NOD1	Nucleotide-binding oligomerization domain containing 1. (953 aa)
	TLR2	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
	PGLYRP1	Peptidoglycan-recognition protein; Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Involved in innate immunity. (196 aa)
	PGLYRP2	Peptidoglycan recognition protein 2. (634 aa)
	NOD2	Nucleotide-binding oligomerization domain-containing protein 2; Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3, INAVA and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macroph [...] (1040 aa)
	CLEC7A	C-type lectin domain containing 7A. (247 aa)
	CLEC4D	CLEC4D isoform 2. (215 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CARD8	NLRP6	ENSPTRP00000068031	ENSPTRP00000005475	Caspase recruitment domain family member 8.	NLR family pyrin domain containing 6.	0.671
CARD8	NOD2	ENSPTRP00000068031	ENSPTRP00000013836	Caspase recruitment domain family member 8.	Nucleotide-binding oligomerization domain-containing protein 2; Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3, INAVA and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macroph [...]	0.502
CD14	LY96	ENSPTRP00000068640	ENSPTRP00000083213	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...]	Lymphocyte antigen 96.	0.973
CD14	TLR2	ENSPTRP00000068640	ENSPTRP00000028379	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...]	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]	0.979
CD14	TLR4	ENSPTRP00000068640	ENSPTRP00000036398	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...]	Toll-like receptor 4; Belongs to the Toll-like receptor family.	0.978
CD14	TLR7	ENSPTRP00000068640	ENSPTRP00000047494	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...]	Toll like receptor 7; Belongs to the Toll-like receptor family.	0.510
CD14	TLR8	ENSPTRP00000068640	ENSPTRP00000062546	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...]	TLR8 isoform 2; Belongs to the Toll-like receptor family.	0.446
CD14	TLR9	ENSPTRP00000068640	ENSPTRP00000083908	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...]	T0016681 isoform 1.	0.485
CD36	CLEC7A	ENSPTRP00000074671	ENSPTRP00000007983	CD36 molecule (Thrombospondin receptor); Belongs to the CD36 family.	C-type lectin domain containing 7A.	0.609
CD36	LY96	ENSPTRP00000074671	ENSPTRP00000083213	CD36 molecule (Thrombospondin receptor); Belongs to the CD36 family.	Lymphocyte antigen 96.	0.500
CD36	PTAFR	ENSPTRP00000074671	ENSPTRP00000000744	CD36 molecule (Thrombospondin receptor); Belongs to the CD36 family.	Platelet activating factor receptor; Belongs to the G-protein coupled receptor 1 family.	0.434
CD36	TLR2	ENSPTRP00000074671	ENSPTRP00000028379	CD36 molecule (Thrombospondin receptor); Belongs to the CD36 family.	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]	0.945
CD36	TLR4	ENSPTRP00000074671	ENSPTRP00000036398	CD36 molecule (Thrombospondin receptor); Belongs to the CD36 family.	Toll-like receptor 4; Belongs to the Toll-like receptor family.	0.874
CLEC4D	CLEC4E	ENSPTRP00000007917	ENSPTRP00000007918	CLEC4D isoform 2.	C-type lectin domain family 4 member E.	0.969
CLEC4D	CLEC6A	ENSPTRP00000007917	ENSPTRP00000050469	CLEC4D isoform 2.	C-type lectin domain family 6 member A.	0.790
CLEC4D	CLEC7A	ENSPTRP00000007917	ENSPTRP00000007983	CLEC4D isoform 2.	C-type lectin domain containing 7A.	0.751
CLEC4E	CLEC4D	ENSPTRP00000007918	ENSPTRP00000007917	C-type lectin domain family 4 member E.	CLEC4D isoform 2.	0.969
CLEC4E	CLEC6A	ENSPTRP00000007918	ENSPTRP00000050469	C-type lectin domain family 4 member E.	C-type lectin domain family 6 member A.	0.580
CLEC4E	NOD2	ENSPTRP00000007918	ENSPTRP00000013836	C-type lectin domain family 4 member E.	Nucleotide-binding oligomerization domain-containing protein 2; Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3, INAVA and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macroph [...]	0.401
CLEC4E	TLR2	ENSPTRP00000007918	ENSPTRP00000028379	C-type lectin domain family 4 member E.	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]	0.636