STRINGSTRING
TGFB1 TGFB1 TNFRSF14 TNFRSF14 PLA2G2D PLA2G2D PLA2G2F PLA2G2F GLMN GLMN ZBTB7B ZBTB7B RC3H1 RC3H1 IL2RA IL2RA DLG5 DLG5 SCGB1A1 SCGB1A1 PAWR PAWR BMP4 BMP4 ARG2 ARG2 FOXJ1 FOXJ1 TWSG1 TWSG1 CLEC4G CLEC4G IHH IHH LILRB1 LILRB1 SCRIB-2 SCRIB-2 ENSPTRP00000093022 ENSPTRP00000093022 PDCD1LG2 PDCD1LG2 ICOSLG ICOSLG PTEN PTEN LGALS9 LGALS9 GPNMB GPNMB CEBPB CEBPB SDC4 SDC4 CK820_G0028374 CK820_G0028374 BMP4-2 BMP4-2 CTLA4 CTLA4 SFTPD SFTPD CDKN2A CDKN2A SHH SHH PRNP PRNP LILRB4 LILRB4 CK820_G0030371 CK820_G0030371 ERBB2 ERBB2 TSPAN32 TSPAN32 ENSPTRP00000068326 ENSPTRP00000068326 LRRC32 LRRC32 SPN-2 SPN-2 DLG1 DLG1 VTCN1 VTCN1 MARCHF7 MARCHF7 BTN2A2 BTN2A2 SCRIB SCRIB MAD1L1 MAD1L1 PATR-G PATR-G IL4I1 IL4I1 CASP3 CASP3 SPN SPN PTPN6 PTPN6 CRTAM CRTAM PRKAR1A PRKAR1A PDE5A PDE5A ENSPTRP00000043137 ENSPTRP00000043137 ITCH ITCH VSIR VSIR PELI1 PELI1 VSIG4 VSIG4 FOXP3 FOXP3 CD274 CD274 IDO1 IDO1 ARG1 ARG1 LRRC1 LRRC1 TNFRSF21 TNFRSF21 HAVCR2 HAVCR2 NDFIP1 NDFIP1 TMEM131L TMEM131L IL20RB IL20RB CD86 CD86 CD80 CD80 CBLB CBLB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
TNFRSF14Tumor necrosis factor receptor superfamily, member 14 (Herpesvirus entry mediator). (283 aa)
PLA2G2DPhospholipase A(2). (161 aa)
PLA2G2FPhospholipase A(2). (211 aa)
GLMNGlomulin, FKBP associated protein. (594 aa)
ZBTB7BZinc finger and BTB domain containing 7B. (573 aa)
RC3H1Ring finger and CCCH-type domains 1. (1134 aa)
IL2RAInterleukin-2 receptor subunit alpha; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. (272 aa)
DLG5Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1919 aa)
SCGB1A1Secretoglobin family 1A member 1. (91 aa)
PAWRPRKC, apoptosis, WT1, regulator. (340 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
ARG2Arginase. (354 aa)
FOXJ1FOXJ1 isoform 1. (421 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (223 aa)
CLEC4GC-type lectin domain family 4 member G. (293 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
LILRB1LILRB1 isoform 3. (697 aa)
SCRIB-2Scribbled homolog. (1662 aa)
ENSPTRP00000093022annotation not available (563 aa)
PDCD1LG2Programmed cell death 1 ligand 2. (288 aa)
ICOSLGICOSLG isoform 3. (590 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
LGALS9Galectin. (355 aa)
GPNMBGPNMB isoform 2. (574 aa)
CEBPBCCAAT/enhancer-binding protein. (347 aa)
SDC4Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (198 aa)
CK820_G0028374Galectin. (343 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
CTLA4Cytotoxic T-lymphocyte associated protein 4. (223 aa)
SFTPDSurfactant protein D. (375 aa)
CDKN2ACyclin-dependent kinase inhibitor 2A (Melanoma, p16, inhibits CDK4). (173 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
PRNPMajor prion protein; Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan s [...] (253 aa)
LILRB4LILRB4 isoform 7. (449 aa)
CK820_G0030371Galectin. (135 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
TSPAN32TSPAN32 isoform 3; Belongs to the tetraspanin (TM4SF) family. (320 aa)
ENSPTRP00000068326annotation not available (488 aa)
LRRC32Leucine rich repeat containing 32. (662 aa)
SPN-2SPN isoform 1. (418 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (926 aa)
VTCN1V-set domain containing T cell activation inhibitor 1. (285 aa)
MARCHF7MARCH7 isoform 6. (666 aa)
BTN2A2Butyrophilin subfamily 2 member A2. (532 aa)
SCRIBSCRIB isoform 8. (959 aa)
MAD1L1MAD1 mitotic arrest deficient-like 1. (718 aa)
PATR-GPatr class I histocompatibility antigen, alpha chain G; Involved in the presentation of foreign antigens to the immune system. (371 aa)
IL4I1Amine oxidase. (589 aa)
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. (277 aa)
SPNSPN isoform 3. (400 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
CRTAMCytotoxic and regulatory T cell molecule. (393 aa)
PRKAR1AProtein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1). (381 aa)
PDE5APhosphodiesterase. (875 aa)
ENSPTRP00000043137Galectin-1. (130 aa)
ITCHE3 ubiquitin-protein ligase. (862 aa)
VSIRChromosome 10 open reading frame 54. (311 aa)
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
VSIG4V-set and immunoglobulin domain containing 4. (399 aa)
FOXP3FOXP3 isoform 4. (456 aa)
CD274CD274 isoform 2. (290 aa)
IDO1IDO1 isoform 2. (403 aa)
ARG1Arginase. (322 aa)
LRRC1Leucine rich repeat containing 1. (524 aa)
TNFRSF21TNFRSF21 isoform 1. (655 aa)
HAVCR2Hepatitis A virus cellular receptor 2. (301 aa)
NDFIP1Nedd4 family interacting protein 1. (221 aa)
TMEM131LTMEM131L isoform 3. (1617 aa)
IL20RBInterleukin 20 receptor subunit beta. (311 aa)
CD86CD86 isoform 3. (329 aa)
CD80CD80 isoform 1. (288 aa)
CBLBCas-Br-M (Murine) ecotropic retroviral transforming sequence b. (982 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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