STRINGSTRING
SUMO1-3 SUMO1-3 ENSPTRP00000085903 ENSPTRP00000085903 FERMT1 FERMT1 SUMO1 SUMO1 SMAD3 SMAD3 RBM22 RBM22 ENSPTRP00000093929 ENSPTRP00000093929 ANGPT1 ANGPT1 PTGS2 PTGS2 BAG3 BAG3 ZPR1 ZPR1 IFNG IFNG IPO5 IPO5 PRKD1 PRKD1 BMP4 BMP4 PSEN1 PSEN1 CHP1 CHP1 CHP2 CHP2 CDH1 CDH1 NF1 NF1 JUP JUP SIRT6 SIRT6 PIK3R2 PIK3R2 TGFB1 TGFB1 MAVS MAVS PRKCD PRKCD HCLS1 HCLS1 NUP54 NUP54 HDAC3 HDAC3 MAPK14 MAPK14 HSP90AB1 HSP90AB1 EPM2A EPM2A GLI3 GLI3 MDFIC MDFIC SMO SMO PKIA PKIA UBR5 UBR5 NOLC1 NOLC1 DMAP1 DMAP1 HYAL2 HYAL2 CDK1 CDK1 TPR TPR EFCAB7 EFCAB7 FLNA FLNA TRIM28 TRIM28 ENSPTRP00000065777 ENSPTRP00000065777 XBP1 XBP1 CK820_G0033528 CK820_G0033528 SMO-2 SMO-2 PKIG PKIG ZC3H12A ZC3H12A ZIC1 ZIC1 CABP1 CABP1 LEP LEP SUFU SUFU RAB23 RAB23 UFM1 UFM1 CD36 CD36 PTPN22 PTPN22 SHH SHH PIK3R1 PIK3R1 ECT2 ECT2 NUP58 NUP58 APOD APOD BMP4-2 BMP4-2 ENSPTRP00000081322 ENSPTRP00000081322 RAN RAN JAK2 JAK2 SUMO1-2 SUMO1-2 ENSPTRP00000085085 ENSPTRP00000085085
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SUMO1-3Small ubiquitin-related modifier. (98 aa)
ENSPTRP00000085903annotation not available (98 aa)
FERMT1Fermitin family member 1. (677 aa)
SUMO1SUMO1 isoform 3. (146 aa)
SMAD3Mothers against decapentaplegic homolog. (442 aa)
RBM22RNA binding motif protein 22. (423 aa)
ENSPTRP00000093929annotation not available (69 aa)
ANGPT1ANGPT1 isoform 2. (498 aa)
PTGS2Prostaglandin-endoperoxide synthase 2 (Prostaglandin G/H synthase and cyclooxygenase). (604 aa)
BAG3BCL2-associated athanogene 3. (575 aa)
ZPR1Zinc finger protein 259. (459 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). (166 aa)
IPO5IPO5 isoform 3. (1115 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (873 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
CHP1Calcineurin like EF-hand protein 1. (195 aa)
CHP2Calcineurin like EF-hand protein 2. (196 aa)
CDH1CDH1 isoform 1; Cadherins are calcium-dependent cell adhesion proteins. (882 aa)
NF1Neurofibromin 1. (2839 aa)
JUPJunction plakoglobin. (745 aa)
SIRT6SIRT6 isoform 1. (355 aa)
PIK3R2Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (728 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
MAVSMitochondrial antiviral signaling protein. (449 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
HCLS1Hematopoietic cell-specific Lyn substrate 1. (484 aa)
NUP54Nucleoporin 54kDa. (458 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
MAPK14Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] (360 aa)
HSP90AB1HSP90AB1 isoform 1. (688 aa)
EPM2AEPM2A glucan phosphatase, laforin. (331 aa)
GLI3Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa)
MDFICMyoD family inhibitor domain containing. (357 aa)
SMOSMO isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
PKIAcAMP-dependent protein kinase inhibitor; Belongs to the PKI family. (76 aa)
UBR5Ubiquitin protein ligase E3 component n-recognin 5. (2798 aa)
NOLC1Nucleolar and coiled-body phosphoprotein 1. (701 aa)
DMAP1DNA methyltransferase 1-associated protein 1. (467 aa)
HYAL2Hyaluronidase. (473 aa)
CDK1Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
TPRTranslocated promoter region (To activated MET oncogene). (2363 aa)
EFCAB7EF-hand calcium binding domain 7. (629 aa)
FLNAFLNA isoform 8. (2711 aa)
TRIM28Tripartite motif containing 28. (835 aa)
ENSPTRP00000065777annotation not available (412 aa)
XBP1XBP1 isoform 4. (381 aa)
CK820_G0033528CHP1 isoform 2. (166 aa)
SMO-2Smoothened, frizzled class receptor. (786 aa)
PKIGcAMP-dependent protein kinase inhibitor; Belongs to the PKI family. (76 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (599 aa)
ZIC1Zic family member 1. (447 aa)
CABP1Calcium binding protein 1. (370 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (167 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (519 aa)
RAB23RAB23, member RAS oncogene family. (237 aa)
UFM1Ubiquitin-fold modifier 1; Ubiquitin-like modifier which can be covalently attached to substrate proteins as a monomer or a lysine-linked polymer in a post- translational process called ufmylation. Ufmylation on lysine residues of proteins may play a crucial role in a number of cellular processes. (103 aa)
CD36CD36 molecule (Thrombospondin receptor); Belongs to the CD36 family. (472 aa)
PTPN22Protein tyrosine phosphatase, non-receptor type 22 (Lymphoid). (807 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
PIK3R1Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha). (724 aa)
ECT2Epithelial cell transforming sequence 2 oncogene. (958 aa)
NUP58Nucleoporin like 1. (603 aa)
APODApolipoprotein D. (215 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
ENSPTRP00000081322annotation not available (396 aa)
RANGTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family. (234 aa)
JAK2Tyrosine-protein kinase. (1143 aa)
SUMO1-2Small ubiquitin-related modifier. (82 aa)
ENSPTRP00000085085annotation not available (84 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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