STRINGSTRING
FZD6 FZD6 KCNQ4 KCNQ4 PRRX1 PRRX1 MYO3A MYO3A FGFR2 FGFR2 CHRNA10 CHRNA10 WNT1 WNT1 LRIG3 LRIG3 CEP290 CEP290 FGF9 FGF9 SPRY2 SPRY2 STRC STRC ALDH1A3 ALDH1A3 DVL2 DVL2 NTN1 NTN1 MYO15A MYO15A TCAP TCAP FZD2 FZD2 TBX2 TBX2 SOX9 SOX9 SLC9A3R1 SLC9A3R1 USH1G USH1G HPN HPN OTX1 OTX1 ATP6V1B1 ATP6V1B1 INSIG2 INSIG2 FRZB FRZB GBX2 GBX2 SOD1 SOD1 TBX1 TBX1 TMIE TMIE HESX1 HESX1 PLS1 PLS1 OTOP1 OTOP1 CHRNA9 CHRNA9 SEC24B SEC24B NEUROG1 NEUROG1 POU4F3 POU4F3 FOXI1 FOXI1 SLC44A4 SLC44A4 LRRC1 LRRC1 TBX18 TBX18 SOBP SOBP HOXA1 HOXA1 DLX5 DLX5 INSIG1 INSIG1 FZD3 FZD3 CHD7 CHD7 EYA1 EYA1 CTHRC1 CTHRC1 TPRN TPRN MYO3B MYO3B BCR BCR REST REST COL2A1 COL2A1 SIX4 SIX4 WDPCP WDPCP ATP8A2 ATP8A2 GRXCR2 GRXCR2 USH1C USH1C WNT3A WNT3A PROX1 PROX1 MAFB MAFB EPHB2 EPHB2 FOXG1 FOXG1 ATOH1 ATOH1 GATA2 GATA2 SLITRK6 SLITRK6 TRIOBP TRIOBP DLX6 DLX6 POU3F4 POU3F4 SCRIB SCRIB ZEB1 ZEB1 CDH23 CDH23 CLRN2 CLRN2 GATA3 GATA3 LOC742658 LOC742658 LHFPL5 LHFPL5 WHRN WHRN CLRN1 CLRN1 ZIC1 ZIC1 SIX1 SIX1 MYO6 MYO6 LRIG1 LRIG1 DVL1 DVL1 TIFAB TIFAB DCANP1 DCANP1 FGF8 FGF8 MYO7A MYO7A HMX3 HMX3 PCDH15 PCDH15 HOXA1-2 HOXA1-2 BLOC1S5 BLOC1S5 GRHL3 GRHL3 FGF10 FGF10 HMX2 HMX2 TBX3 TBX3 PAX8 PAX8 ITGA8 ITGA8 ENSPTRP00000085692 ENSPTRP00000085692 WNT5A WNT5A PDZD7 PDZD7 PTK7 PTK7 TFAP2A TFAP2A KCNQ1 KCNQ1 COL11A1 COL11A1 PTPRQ PTPRQ LOC459393 LOC459393 TTC39C TTC39C PAX2 PAX2 TSHR TSHR MYO15B MYO15B SCRIB-2 SCRIB-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FZD6Frizzled homolog 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa)
KCNQ4Potassium voltage-gated channel subfamily Q member 4; Belongs to the potassium channel family. (695 aa)
PRRX1Paired related homeobox 1. (245 aa)
MYO3AMYO3A isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1621 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
CHRNA10Cholinergic receptor nicotinic alpha 10 subunit. (450 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
LRIG3LRIG3 isoform 1. (1119 aa)
CEP290CEP290 isoform 5. (2454 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
SPRY2Sprouty homolog 2. (338 aa)
STRCLOW QUALITY PROTEIN: stereocilin. (1772 aa)
ALDH1A3Aldehyde dehydrogenase 1 family member A3; Belongs to the aldehyde dehydrogenase family. (512 aa)
DVL2Dishevelled segment polarity protein 2. (736 aa)
NTN1NTN1 isoform 1. (604 aa)
MYO15AMyosin XVA. (3517 aa)
TCAPTCAP isoform 1. (167 aa)
FZD2FZD2 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (548 aa)
TBX2T-box transcription factor 2. (712 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (358 aa)
USH1GUSH1 protein network component sans. (461 aa)
HPNHPN isoform 1; Belongs to the peptidase S1 family. (417 aa)
OTX1Orthodenticle homeobox 1. (354 aa)
ATP6V1B1Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (513 aa)
INSIG2Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (225 aa)
FRZBFrizzled-related protein. (325 aa)
GBX2Gastrulation brain homeobox 2. (348 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (154 aa)
TBX1TBX1 isoform 1. (478 aa)
TMIETransmembrane inner ear. (154 aa)
HESX1Homeobox expressed in ES cells 1; Required for the normal development of the forebrain, eyes and other anterior structures such as the olfactory placodes and pituitary gland. Possible transcriptional repressor. Binds to the palindromic PIII sequence, 5'-AGCTTGAGTCTAATTGAATTAACTGTAC-3'. HESX1 and PROP1 bind as heterodimers on this palindromic site, and, in vitro, HESX1 can antagonize PROP1 activation (By similarity). (185 aa)
PLS1Plastin 1 (I isoform). (629 aa)
OTOP1OTOP1 isoform 1. (612 aa)
CHRNA9Cholinergic receptor nicotinic alpha 9 subunit. (479 aa)
SEC24BSEC24B isoform 1. (1286 aa)
NEUROG1NEUROG1 isoform 1. (237 aa)
POU4F3POU domain, class 4, transcription factor 3. (338 aa)
FOXI1FOXI1 isoform 2. (378 aa)
SLC44A4Solute carrier family 44 member 4; Belongs to the CTL (choline transporter-like) family. (710 aa)
LRRC1Leucine rich repeat containing 1. (524 aa)
TBX18T-box transcription factor 18. (607 aa)
SOBPSine oculis binding protein homolog. (873 aa)
HOXA1HOXA1 isoform 2. (335 aa)
DLX5Distal-less homeobox 5. (289 aa)
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (277 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
CHD7CHD7 isoform 1. (2997 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
CTHRC1Collagen triple helix repeat containing 1. (243 aa)
TPRNTPRN isoform 2. (634 aa)
MYO3BMYO3B isoform 3; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1341 aa)
BCRBCR activator of RhoGEF and GTPase. (1271 aa)
RESTRE1 silencing transcription factor. (1097 aa)
COL2A1Collagen type II alpha 1 chain. (1487 aa)
SIX4SIX homeobox 4. (781 aa)
WDPCPWDPCP isoform 2. (746 aa)
ATP8A2Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1188 aa)
GRXCR2GRXCR2 isoform 1. (248 aa)
USH1CUSH1C isoform 4. (899 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
PROX1Prospero homeobox 1. (737 aa)
MAFBV-maf musculoaponeurotic fibrosarcoma oncogene homolog B (Avian). (323 aa)
EPHB2EPH receptor B2. (1055 aa)
FOXG1FOXG1 isoform 8. (489 aa)
ATOH1Protein atonal homolog 1; Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity). (356 aa)
GATA2GATA binding protein 2. (480 aa)
SLITRK6SLITRK6 isoform 1. (841 aa)
TRIOBPTRIOBP isoform 1. (2139 aa)
DLX6DLX6 isoform 1. (295 aa)
POU3F4POU domain protein. (361 aa)
SCRIBSCRIB isoform 8. (959 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1127 aa)
CDH23CDH23 isoform 1. (3359 aa)
CLRN2CLRN2 isoform 1. (232 aa)
GATA3GATA binding protein 3. (444 aa)
LOC742658Stereocilin-like. (1726 aa)
LHFPL5LHFPL tetraspan subfamily member 5. (219 aa)
WHRNWHRN isoform 2. (907 aa)
CLRN1T0022075 isoform 1. (245 aa)
ZIC1Zic family member 1. (447 aa)
SIX1SIX homeobox 1. (284 aa)
MYO6MYO6 isoform 3; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1290 aa)
LRIG1LRIG1 isoform 3. (1091 aa)
DVL1Segment polarity protein dishevelled homolog DVL-1; Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) (By simi [...] (743 aa)
TIFABTIFAB isoform 1. (161 aa)
DCANP1LOW QUALITY PROTEIN: dendritic cell nuclear protein 1. (237 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
MYO7AMYO7A isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2222 aa)
HMX3H6 family homeobox 3. (357 aa)
PCDH15Protocadherin related 15. (1954 aa)
HOXA1-2Homeobox A1. (335 aa)
BLOC1S5Biogenesis of lysosome-related organelles complex 1 subunit 5; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO). (220 aa)
GRHL3Grainyhead like transcription factor 3. (626 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
HMX2H6 family homeobox 2. (273 aa)
TBX3T-box transcription factor 3. (743 aa)
PAX8PAX8 isoform 1. (456 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1063 aa)
ENSPTRP00000085692annotation not available (679 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
PDZD7PDZD7 isoform 1. (1035 aa)
PTK7Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1078 aa)
TFAP2ATranscription factor AP-2 alpha. (439 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (676 aa)
COL11A1Collagen type XI alpha 1 chain. (1818 aa)
PTPRQPTPRQ isoform 2. (2158 aa)
LOC459393Otopetrin-1-like. (563 aa)
TTC39CTetratricopeptide repeat domain 39C. (584 aa)
PAX2PAX2 isoform 1. (417 aa)
TSHRThyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (764 aa)
MYO15BMYO15B isoform 5; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (3036 aa)
SCRIB-2Scribbled homolog. (1662 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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