STRINGSTRING
EDA EDA BMPR1A BMPR1A HTRA1 HTRA1 ADM ADM TRAF6 TRAF6 TCIRG1 TCIRG1 FGF4 FGF4 MMP20 MMP20 BMP4 BMP4 CK820_G0025122 CK820_G0025122 SMPD3 SMPD3 NGFR NGFR DLX3 DLX3 GATA6 GATA6 BSG BSG TGFB1 TGFB1 KLK4 KLK4 KLK5 KLK5 CNNM4 CNNM4 EDAR EDAR ACVR2A ACVR2A DLX2 DLX2 BMP2 BMP2 BMP7 BMP7 TBX1 TBX1 PPARA PPARA TP63 TP63 ODAM ODAM AMTN AMTN DSPP DSPP FST FST CTNNA1 CTNNA1 HAND1 HAND1 SLC34A1 SLC34A1 ENSPTRP00000031829 ENSPTRP00000031829 GLI3 GLI3 SERPINE1 SERPINE1 CFTR CFTR SMO SMO SLC4A2 SLC4A2 DLX1 DLX1 GLI2 GLI2 AMBN AMBN SCN10A SCN10A CCDC154 CCDC154 CTNNB1 CTNNB1 HDAC2 HDAC2 HAND2 HAND2 WDR72 WDR72 BCL11B BCL11B FAM20A FAM20A MSX1 MSX1 AMELX AMELX ATF2 ATF2 ENSPTRP00000064416 ENSPTRP00000064416 FOXC1 FOXC1 ENSPTRP00000065244 ENSPTRP00000065244 RUNX2 RUNX2 LOC748850 LOC748850 SMO-2 SMO-2 SOSTDC1 SOSTDC1 RELT RELT ROGDI ROGDI SCN5A SCN5A LHX8 LHX8 NF2 NF2 ITGB6 ITGB6 NKX2-3 NKX2-3 SHH SHH HDAC1 HDAC1 JAG2 JAG2 BCL2L11 BCL2L11 ACVR2B ACVR2B STIM1 STIM1 WNT6 WNT6 LEF1 LEF1 NECTIN1 NECTIN1 BMP4-2 BMP4-2 LRP4 LRP4 ENAM ENAM FGF10 FGF10 AMELY AMELY SOSTDC1-2 SOSTDC1-2 LAMA5 LAMA5 ANKRD11-2 ANKRD11-2 ANKRD11 ANKRD11 PERP PERP BAX BAX
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EDAEctodysplasin A; Belongs to the tumor necrosis factor family. (391 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
HTRA1HtrA serine peptidase 1. (522 aa)
ADMAdrenomedullin. (185 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (830 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
MMP20Matrix metallopeptidase 20. (483 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
CK820_G0025122SLC24A4 isoform 1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (343 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (655 aa)
NGFRNerve growth factor receptor. (427 aa)
DLX3Distal-less homeobox 3. (287 aa)
GATA6GATA binding protein 6. (594 aa)
BSGBSG isoform 8. (383 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
KLK4Kallikrein related peptidase 4; Belongs to the peptidase S1 family. (254 aa)
KLK5Kallikrein related peptidase 5; Belongs to the peptidase S1 family. (293 aa)
CNNM4Cyclin and CBS domain divalent metal cation transport mediator 4. (775 aa)
EDAREctodysplasin A receptor. (496 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
DLX2Distal-less homeobox 2. (328 aa)
BMP2Bone morphogenetic protein 2. (398 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
TBX1TBX1 isoform 1. (478 aa)
PPARAPeroxisome proliferator-activated receptor alpha. (467 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
ODAMOdontogenic ameloblast-associated protein; Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface; Belongs to the ODAM family. (279 aa)
AMTNAMTN isoform 1. (209 aa)
DSPPDSPP isoform 1. (1292 aa)
FSTFST isoform 1. (344 aa)
CTNNA1CTNNA1 isoform 21. (906 aa)
HAND1Heart and neural crest derivatives expressed 1. (215 aa)
SLC34A1SLC34A1 isoform 1. (626 aa)
ENSPTRP00000031829annotation not available (188 aa)
GLI3Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (402 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1480 aa)
SMOSMO isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
SLC4A2Anion exchange protein. (1239 aa)
DLX1Distal-less homeobox 1. (255 aa)
GLI2GLI family zinc finger 2. (1587 aa)
AMBNAMBN isoform 1. (447 aa)
SCN10ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1959 aa)
CCDC154Coiled-coil domain containing 154. (522 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
HDAC2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (581 aa)
HAND2Heart and neural crest derivatives expressed 2. (217 aa)
WDR72WD repeat domain 72. (1102 aa)
BCL11BBAF chromatin remodeling complex subunit BCL11B. (894 aa)
FAM20AFAM20A golgi associated secretory pathway pseudokinase. (541 aa)
MSX1Homeobox protein MSX-1; Acts as a transcriptional repressor. May play a role in limb- pattern formation. Acts in cranofacial development and specifically in odontogenesis (By similarity). (303 aa)
AMELXAmelogenin X-linked. (205 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
ENSPTRP00000064416annotation not available (502 aa)
FOXC1FOXC1 isoform 1. (550 aa)
ENSPTRP00000065244annotation not available (463 aa)
RUNX2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (569 aa)
LOC748850HDAC2 isoform 9. (445 aa)
SMO-2Smoothened, frizzled class receptor. (786 aa)
SOSTDC1Sclerostin domain containing 1. (230 aa)
RELTRELT tumor necrosis factor receptor. (430 aa)
ROGDIROGDI isoform 1. (294 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2016 aa)
LHX8LHX8 isoform 2. (377 aa)
NF2Neurofibromin 2 (Merlin). (595 aa)
ITGB6ITGB6 isoform 3. (701 aa)
NKX2-3NKX2-3 isoform 1. (366 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
JAG2Jagged canonical Notch ligand 2. (1130 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (512 aa)
STIM1Stromal interaction molecule 1. (791 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
LEF1Lymphoid enhancer binding factor 1. (414 aa)
NECTIN1NECTIN1 isoform 1. (517 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
LRP4Low density lipoprotein receptor-related protein 4. (1906 aa)
ENAMENAM isoform 1. (1142 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
AMELYAmelogenin, Y isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel (By similarity). Belongs to the amelogenin family. (206 aa)
SOSTDC1-2Sclerostin domain containing 1. (206 aa)
LAMA5Laminin, alpha 5. (2203 aa)
ANKRD11-2Ankyrin repeat domain-containing protein 11. (112 aa)
ANKRD11Ankyrin repeat domain 11. (2610 aa)
PERPP53 apoptosis effector related to PMP22. (193 aa)
BAXBAX isoform 7. (123 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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