19 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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Predicted Interactions

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Your Input:
	BMP4-2	Bone morphogenetic protein 4. (408 aa)
	PAX9	Paired box protein Pax-9; Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs. (347 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	SP6	Sp6 transcription factor. (376 aa)
	NGFR	Nerve growth factor receptor. (427 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	WNT10A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
	BMP2	Bone morphogenetic protein 2. (398 aa)
	EDN1	EDN1 isoform 1. (212 aa)
	TNFRSF11B	Tumor necrosis factor receptor superfamily member 11B; Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. (428 aa)
	CD34	CD34 isoform 1. (328 aa)
	DMRT3	Doublesex and mab-3 related transcription factor 3. (472 aa)
	APCDD1	Adenomatosis polyposis coli down-regulated 1. (514 aa)
	MSX1	Homeobox protein MSX-1; Acts as a transcriptional repressor. May play a role in limb- pattern formation. Acts in cranofacial development and specifically in odontogenesis (By similarity). (303 aa)
	RSPO2	R-spondin 2 homolog. (243 aa)
	RUNX2	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (569 aa)
	CSF1	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (585 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APCDD1	SHH	ENSPTRP00000049514	ENSPTRP00000075730	Adenomatosis polyposis coli down-regulated 1.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.482
BMP2	BMP4	ENSPTRP00000022701	ENSPTRP00000010780	Bone morphogenetic protein 2.	Bone morphogenetic protein 4.	0.951
BMP2	BMP4-2	ENSPTRP00000022701	ENSPTRP00000080656	Bone morphogenetic protein 2.	Bone morphogenetic protein 4.	0.530
BMP2	CD34	ENSPTRP00000022701	ENSPTRP00000003262	Bone morphogenetic protein 2.	CD34 isoform 1.	0.544
BMP2	FGF8	ENSPTRP00000022701	ENSPTRP00000075677	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.662
BMP2	MSX1	ENSPTRP00000022701	ENSPTRP00000055966	Bone morphogenetic protein 2.	Homeobox protein MSX-1; Acts as a transcriptional repressor. May play a role in limb- pattern formation. Acts in cranofacial development and specifically in odontogenesis (By similarity).	0.572
BMP2	RUNX2	ENSPTRP00000022701	ENSPTRP00000065999	Bone morphogenetic protein 2.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.904
BMP2	SHH	ENSPTRP00000022701	ENSPTRP00000075730	Bone morphogenetic protein 2.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.613
BMP2	TGFB1	ENSPTRP00000022701	ENSPTRP00000018930	Bone morphogenetic protein 2.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.548
BMP4	BMP2	ENSPTRP00000010780	ENSPTRP00000022701	Bone morphogenetic protein 4.	Bone morphogenetic protein 2.	0.951
BMP4	CD34	ENSPTRP00000010780	ENSPTRP00000003262	Bone morphogenetic protein 4.	CD34 isoform 1.	0.592
BMP4	FGF8	ENSPTRP00000010780	ENSPTRP00000075677	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.724
BMP4	MSX1	ENSPTRP00000010780	ENSPTRP00000055966	Bone morphogenetic protein 4.	Homeobox protein MSX-1; Acts as a transcriptional repressor. May play a role in limb- pattern formation. Acts in cranofacial development and specifically in odontogenesis (By similarity).	0.682
BMP4	PAX9	ENSPTRP00000010780	ENSPTRP00000010655	Bone morphogenetic protein 4.	Paired box protein Pax-9; Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs.	0.576
BMP4	RUNX2	ENSPTRP00000010780	ENSPTRP00000065999	Bone morphogenetic protein 4.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.732
BMP4	SHH	ENSPTRP00000010780	ENSPTRP00000075730	Bone morphogenetic protein 4.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.720
BMP4-2	BMP2	ENSPTRP00000080656	ENSPTRP00000022701	Bone morphogenetic protein 4.	Bone morphogenetic protein 2.	0.530
BMP4-2	CD34	ENSPTRP00000080656	ENSPTRP00000003262	Bone morphogenetic protein 4.	CD34 isoform 1.	0.592
BMP4-2	FGF8	ENSPTRP00000080656	ENSPTRP00000075677	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.724
BMP4-2	MSX1	ENSPTRP00000080656	ENSPTRP00000055966	Bone morphogenetic protein 4.	Homeobox protein MSX-1; Acts as a transcriptional repressor. May play a role in limb- pattern formation. Acts in cranofacial development and specifically in odontogenesis (By similarity).	0.682