STRINGSTRING
BMP4-2 BMP4-2 PAX9 PAX9 BMP4 BMP4 SP6 SP6 NGFR NGFR TGFB1 TGFB1 WNT10A WNT10A BMP2 BMP2 EDN1 EDN1 TNFRSF11B TNFRSF11B CD34 CD34 DMRT3 DMRT3 APCDD1 APCDD1 MSX1 MSX1 RSPO2 RSPO2 RUNX2 RUNX2 CSF1 CSF1 FGF8 FGF8 SHH SHH
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BMP4-2Bone morphogenetic protein 4. (408 aa)
PAX9Paired box protein Pax-9; Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs. (347 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
SP6Sp6 transcription factor. (376 aa)
NGFRNerve growth factor receptor. (427 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
BMP2Bone morphogenetic protein 2. (398 aa)
EDN1EDN1 isoform 1. (212 aa)
TNFRSF11BTumor necrosis factor receptor superfamily member 11B; Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. (428 aa)
CD34CD34 isoform 1. (328 aa)
DMRT3Doublesex and mab-3 related transcription factor 3. (472 aa)
APCDD1Adenomatosis polyposis coli down-regulated 1. (514 aa)
MSX1Homeobox protein MSX-1; Acts as a transcriptional repressor. May play a role in limb- pattern formation. Acts in cranofacial development and specifically in odontogenesis (By similarity). (303 aa)
RSPO2R-spondin 2 homolog. (243 aa)
RUNX2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (569 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (585 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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