STRINGSTRING
HES5-2 HES5-2 GPC1 GPC1 ERCC2 ERCC2 ENSPTRP00000079007 ENSPTRP00000079007 NTRK2 NTRK2 MPDZ MPDZ TSPAN2 TSPAN2 CNTN1 CNTN1 DHH DHH SCN2A SCN2A ABCA2 ABCA2 MARVELD1 MARVELD1 JAM3 JAM3 KLK6 KLK6 ARHGEF10 ARHGEF10 ABCD1 ABCD1 ID4 ID4 ENSPTRP00000070794 ENSPTRP00000070794 ERBB2 ERBB2 OLIG2 OLIG2 ILK ILK KEL KEL MAL2 MAL2 TSC1 TSC1 LPAR1 LPAR1 ADAM22 ADAM22 CNTNAP1 CNTNAP1 POU3F1 POU3F1 CD22-2 CD22-2 DICER1 DICER1 MTMR2 MTMR2 ANK2 ANK2 MPZ MPZ CK820_G0014110 CK820_G0014110 ADGRG6 ADGRG6 PARD3 PARD3 SCN8A SCN8A SOX10 SOX10 HES5 HES5 PLP1 PLP1 PLEC PLEC NDRG1 NDRG1 CLU CLU GJC3 GJC3 FAM126A FAM126A TNFRSF21 TNFRSF21 SH3TC2 SH3TC2 SLC25A46 SLC25A46 UGT8 UGT8 EIF2B5 EIF2B5 AMIGO3 AMIGO3 DAG1 DAG1 CMTM8 CMTM8 GAL3ST1 GAL3ST1 SOD1 SOD1 B4GALT5 B4GALT5 ATRN ATRN PIKFYVE PIKFYVE NAB1 NAB1 SH3TC1 SH3TC1 ENSPTRP00000082526 ENSPTRP00000082526 ITGB4 ITGB4 AKT1 AKT1 SBF2 SBF2 FIG4 FIG4 QKI QKI CNTN2 CNTN2 SERINC5 SERINC5 HEXB HEXB NFASC NFASC AKT2 AKT2 CELF6-2 CELF6-2 NTF3 NTF3 ADAM22-2 ADAM22-2 SLC8A3 SLC8A3 PTEN PTEN BCAS1 BCAS1 TPPP TPPP MBP MBP NRG1 NRG1 ENSPTRP00000093022 ENSPTRP00000093022 NCSTN NCSTN GNPAT GNPAT ORMDL1 ORMDL1 MALL MALL MAL MAL EIF2B4 EIF2B4 TGFB1 TGFB1 PRX PRX SIRT2 SIRT2 LGI4 LGI4 ZNF24 ZNF24 B4GALT6 B4GALT6 AFG3L2 AFG3L2 EPB41L3 EPB41L3 ORMDL3 ORMDL3 NF1 NF1 ASPA ASPA FA2H FA2H PLLP PLLP ACSBG1 ACSBG1 GALC GALC EIF2B2 EIF2B2 MPP5 MPP5 NAB2 NAB2 ABCD2 ABCD2 CD9 CD9 TENM4 TENM4 ACER3 ACER3 ACY3 ACY3 MYRF MYRF NKX6-2 NKX6-2 EGR2 EGR2 DEGS1 DEGS1 MYOC MYOC AMIGO1 AMIGO1 NCMAP NCMAP SKI SKI
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HES5-2Hes family bHLH transcription factor 5. (165 aa)
GPC1GPC1 isoform 1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (558 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (760 aa)
ENSPTRP00000079007annotation not available (323 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
MPDZMultiple PDZ domain crumbs cell polarity complex component. (2084 aa)
TSPAN2Tetraspanin. (228 aa)
CNTN1CNTN1 isoform 1. (1028 aa)
DHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (396 aa)
SCN2ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2005 aa)
ABCA2ABCA2 isoform 8. (2364 aa)
MARVELD1MARVEL domain containing 1. (173 aa)
JAM3Junctional adhesion molecule 3. (310 aa)
KLK6Kallikrein related peptidase 6; Belongs to the peptidase S1 family. (244 aa)
ARHGEF10ARHGEF10 isoform 4. (1416 aa)
ABCD1ATP-binding cassette, sub-family D (ALD), member 1. (745 aa)
ID4Inhibitor of DNA binding 4, dominant negative helix-loop-helix protein. (161 aa)
ENSPTRP00000070794annotation not available (426 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
OLIG2OLIG2 isoform 1. (323 aa)
ILKIntegrin-linked kinase. (533 aa)
KELKell metallo-endopeptidase. (732 aa)
MAL2Mal, T cell differentiation protein 2. (176 aa)
TSC1TSC complex subunit 1. (1164 aa)
LPAR1Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (366 aa)
ADAM22ADAM metallopeptidase domain 22. (906 aa)
CNTNAP1Contactin associated protein 1. (1384 aa)
POU3F1POU domain protein. (451 aa)
CD22-2B-cell receptor CD22. (626 aa)
DICER1Dicer 1, ribonuclease type III; Belongs to the helicase family. Dicer subfamily. (1922 aa)
MTMR2MTMR2 isoform 3. (643 aa)
ANK2ANK2 isoform 1. (3957 aa)
MPZMyelin protein zero. (248 aa)
CK820_G0014110KEL isoform 1. (732 aa)
ADGRG6Adhesion G protein-coupled receptor G6; Belongs to the G-protein coupled receptor 2 family. (1250 aa)
PARD3PARD3 isoform 2. (1356 aa)
SCN8ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1991 aa)
SOX10SRY-box transcription factor 10. (466 aa)
HES5Hes family bHLH transcription factor 5. (165 aa)
PLP1Proteolipid protein 1. (277 aa)
PLECPLEC isoform 2. (4684 aa)
NDRG1NDRG1 isoform 2. (394 aa)
CLUClusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. (449 aa)
GJC3Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (279 aa)
FAM126AFamily with sequence similarity 126, member A. (521 aa)
TNFRSF21TNFRSF21 isoform 1. (655 aa)
SH3TC2SH3TC2 isoform 8. (1288 aa)
SLC25A46Solute carrier family 25, member 46; Belongs to the mitochondrial carrier (TC 2.A.29) family. (418 aa)
UGT8UGT8 isoform 1; Belongs to the UDP-glycosyltransferase family. (541 aa)
EIF2B5Eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa. (721 aa)
AMIGO3AMIGO3 isoform 1. (504 aa)
DAG1Dystroglycan 1 (Dystrophin-associated glycoprotein 1). (895 aa)
CMTM8CKLF-like MARVEL transmembrane domain containing 8. (173 aa)
GAL3ST1Galactosylceramide sulfotransferase. (423 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (154 aa)
B4GALT5UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 5. (388 aa)
ATRNATRN isoform 1. (1429 aa)
PIKFYVEPhosphoinositide kinase, FYVE-type zinc finger containing. (2098 aa)
NAB1NGFI-A binding protein 1 (EGR1 binding protein 1). (487 aa)
SH3TC1SH3TC1 isoform 2. (1336 aa)
ENSPTRP00000082526annotation not available (164 aa)
ITGB4Integrin beta. (1822 aa)
AKT1AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa)
SBF2SET binding factor 2. (1849 aa)
FIG4FIG4 homolog, SAC1 lipid phosphatase domain containing. (924 aa)
QKIQKI, KH domain containing RNA binding. (342 aa)
CNTN2CNTN2 isoform 13. (1040 aa)
SERINC5Serine incorporator 5. (461 aa)
HEXBBeta-hexosaminidase. (557 aa)
NFASCNFASC isoform 1. (1338 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
CELF6-2CUGBP Elav-like family member 6 isoform X1. (538 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (275 aa)
ADAM22-2ADAM22 isoform 3. (923 aa)
SLC8A3Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (927 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
BCAS1Breast carcinoma amplified sequence 1. (650 aa)
TPPPTubulin polymerization promoting protein. (219 aa)
MBPMyelin basic protein; Is, with PLP, the most abundant protein component of the myelin membrane in the CNS. Has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers. Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane (By similarity). (304 aa)
NRG1NRG1 isoform 3. (713 aa)
ENSPTRP00000093022annotation not available (563 aa)
NCSTNNCSTN isoform 1. (721 aa)
GNPATDihydroxyacetone phosphate acyltransferase. (691 aa)
ORMDL1ORM1-like protein; Negative regulator of sphingolipid synthesis. (153 aa)
MALLMal, T cell differentiation protein like. (153 aa)
MALMal, T cell differentiation protein. (153 aa)
EIF2B4Eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa; Belongs to the eIF-2B alpha/beta/delta subunits family. (523 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
PRXPRX isoform 2. (1371 aa)
SIRT2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (389 aa)
LGI4Leucine rich repeat LGI family member 4. (537 aa)
ZNF24Zinc finger protein 24; Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5'-TCAT-3' DNA sequence. Has transcription repressor activity in vitro (By similarity). (368 aa)
B4GALT6UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 6. (382 aa)
AFG3L2AFG3 like matrix AAA peptidase subunit 2. (797 aa)
EPB41L3EPB41L3 isoform 7. (1087 aa)
ORMDL3ORM1-like protein; Negative regulator of sphingolipid synthesis. (153 aa)
NF1Neurofibromin 1. (2839 aa)
ASPAAspartoacylase (Canavan disease). (313 aa)
FA2HFatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...] (372 aa)
PLLPPLLP isoform 1. (182 aa)
ACSBG1Acyl-CoA synthetase bubblegum family member 1. (724 aa)
GALCGalactosylceramidase. (685 aa)
EIF2B2Eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa; Belongs to the eIF-2B alpha/beta/delta subunits family. (351 aa)
MPP5Membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5); Belongs to the MAGUK family. (675 aa)
NAB2NGFI-A binding protein 2 (EGR1 binding protein 2). (525 aa)
ABCD2ATP binding cassette subfamily D member 2. (740 aa)
CD9Tetraspanin. (228 aa)
TENM4Teneurin transmembrane protein 4. (2769 aa)
ACER3Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (267 aa)
ACY3Aspartoacylase (Aminocyclase) 3. (319 aa)
MYRFMYRF isoform 2. (932 aa)
NKX6-2NKX6-2 isoform 1. (276 aa)
EGR2Early growth response 2. (476 aa)
DEGS1Degenerative spermatocyte homolog 1, lipid desaturase. (323 aa)
MYOCMYOC isoform 1. (504 aa)
AMIGO1Adhesion molecule with Ig-like domain 1. (493 aa)
NCMAPNCMAP isoform 2. (102 aa)
SKIV-ski sarcoma viral oncogene homolog (Avian). (736 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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