STRINGSTRING
TBX3 TBX3 WNT5A WNT5A ECE1 ECE1 CHST11 CHST11 BAX BAX TBC1D32 TBC1D32 HAND2 HAND2 OSR2 OSR2 HDAC2 HDAC2 TWIST1 TWIST1 CTNNB1 CTNNB1 WDPCP WDPCP FZD6 FZD6 LMBR1 LMBR1 NOTCH1 NOTCH1 GRHL2 GRHL2 GLI3 GLI3 HOXA11 HOXA11 GNA12 GNA12 CPLANE1 CPLANE1 SFRP2 SFRP2 INTU INTU IFT52 IFT52 IHH IHH HOXD13 HOXD13 LNPK LNPK MAP3K20 MAP3K20 OSR1 OSR1 SMAD4 SMAD4 TBX2 TBX2 MKS1 MKS1 NOG NOG B9D1 B9D1 TMEM107 TMEM107 IFT140 IFT140 BMP4 BMP4 FREM2 FREM2 HOXC11 HOXC11 ZBTB16 ZBTB16 BMPR1A BMPR1A FLVCR1 FLVCR1 TMEM231 TMEM231 MSX1 MSX1 HOXD12 HOXD12 C2CD3 C2CD3 ENSPTRP00000064416 ENSPTRP00000064416 SALL1 SALL1 WNT7A WNT7A TMEM107-2 TMEM107-2 LOC748850 LOC748850 TULP3 TULP3 LRP5 LRP5 ENSPTRP00000069764 ENSPTRP00000069764 IMPAD1 IMPAD1 CREBBP CREBBP SHH SHH HDAC1 HDAC1 BCL2L11 BCL2L11 ENSPTRP00000077262 ENSPTRP00000077262 BMP4-2 BMP4-2 LRP4 LRP4 ALX4 ALX4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TBX3T-box transcription factor 3. (743 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
ECE1Endothelin converting enzyme 1. (770 aa)
CHST11Carbohydrate sulfotransferase. (352 aa)
BAXBAX isoform 7. (123 aa)
TBC1D32TBC1D32 isoform 4. (1298 aa)
HAND2Heart and neural crest derivatives expressed 2. (217 aa)
OSR2Protein odd-skipped-related 2 isoform X4. (433 aa)
HDAC2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (581 aa)
TWIST1TWIST1 isoform 2. (163 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
WDPCPWDPCP isoform 2. (746 aa)
FZD6Frizzled homolog 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa)
LMBR1LMBR1 isoform 7; Belongs to the LIMR family. (531 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
GRHL2Grainyhead like transcription factor 2. (625 aa)
GLI3Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa)
HOXA11HOXA11 isoform 2. (313 aa)
GNA12Guanine nucleotide binding protein (G protein) alpha 12. (381 aa)
CPLANE1Ciliogenesis and planar polarity effector 1. (3197 aa)
SFRP2Secreted frizzled-related protein 2. (295 aa)
INTUInturned planar cell polarity effector homolog. (911 aa)
IFT52Intraflagellar transport 52 homolog. (437 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
HOXD13HOXD13 isoform 1. (344 aa)
LNPKLunapark, ER junction formation factor. (459 aa)
MAP3K20Sterile alpha motif and leucine zipper containing kinase AZK. (803 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
TBX2T-box transcription factor 2. (712 aa)
MKS1MKS transition zone complex subunit 1. (559 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
B9D1B9 domain containing 1. (204 aa)
TMEM107Transmembrane protein 107. (146 aa)
IFT140Intraflagellar transport 140 homolog. (1471 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
FREM2FRAS1 related extracellular matrix 2. (3169 aa)
HOXC11HOXC11 isoform 1. (304 aa)
ZBTB16Zinc finger and BTB domain containing 16. (673 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
FLVCR1Feline leukemia virus subgroup C cellular receptor 1. (569 aa)
TMEM231T0150531 isoform 1. (345 aa)
MSX1Homeobox protein MSX-1; Acts as a transcriptional repressor. May play a role in limb- pattern formation. Acts in cranofacial development and specifically in odontogenesis (By similarity). (303 aa)
HOXD12HOXD12 isoform 1. (270 aa)
C2CD3C2CD3 isoform 3. (2298 aa)
ENSPTRP00000064416annotation not available (502 aa)
SALL1SALL1 isoform 2. (1326 aa)
WNT7AProtein Wnt-7a; Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta- catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes. Required for normal [...] (349 aa)
TMEM107-2Transmembrane protein 107. (140 aa)
LOC748850HDAC2 isoform 9. (445 aa)
TULP3TULP3 isoform 3; Belongs to the TUB family. (501 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1606 aa)
ENSPTRP00000069764annotation not available (1213 aa)
IMPAD1Inositol monophosphatase domain containing 1. (388 aa)
CREBBPCREB binding protein. (2442 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
ENSPTRP00000077262annotation not available (314 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
LRP4Low density lipoprotein receptor-related protein 4. (1906 aa)
ALX4ALX homeobox 4. (411 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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