STRINGSTRING
BHLHE40 BHLHE40 MTOR MTOR THRAP3 THRAP3 PRKAA2 PRKAA2 CHRNB2 CHRNB2 OPN3 OPN3 ATOH7 ATOH7 ADRB1 ADRB1 DRD4 DRD4 KAT5 KAT5 RBM4B RBM4B KDM2A KDM2A USP2 USP2 CRY1 CRY1 PPP1CA PPP1CA PSPC1 PSPC1 PML PML FBXL8 FBXL8 ZFHX3 ZFHX3 TP53 TP53 NR1D1 NR1D1 TOP2A TOP2A PHLPP1 PHLPP1 SIRT6 SIRT6 FBXL12 FBXL12 NR2F6 NR2F6 CRTC1 CRTC1 PRKCG PRKCG ID2 ID2 GHRH GHRH ADORA2A ADORA2A SRRD SRRD PPARA PPARA SPSB4 SPSB4 SIAH2 SIAH2 PPARGC1A PPARGC1A CLOCK CLOCK HNRNPD HNRNPD FBXW7 FBXW7 CSF2 CSF2 HDAC3 HDAC3 MAPK9 MAPK9 HCRTR2 HCRTR2 ADCY1 ADCY1 CCAR2 CCAR2 CRH CRH FBXL6 FBXL6 PTGDS PTGDS SUV39H1 SUV39H1 NONO NONO PASD1 PASD1 MAPK8 MAPK8 TIMELESS TIMELESS PER3 PER3 FBXL3 FBXL3 PRKDC PRKDC SIN3A SIN3A MTNR1B MTNR1B PRKAA1 PRKAA1 GNAQ GNAQ CDK1 CDK1 PROX1 PROX1 NPS NPS KLF10 KLF10 NLGN1 NLGN1 OPN5 OPN5 RORB RORB ROCK2 ROCK2 FBXW9 FBXW9 GHRHR GHRHR PER1 PER1 MAGEL2 MAGEL2 ADCY1-2 ADCY1-2 CSNK1D CSNK1D ARNTL ARNTL SUV39H2 SUV39H2 PIWIL2 PIWIL2 PPP1CB PPP1CB USP9X USP9X ENSPTRP00000068968 ENSPTRP00000068968 KDM2A-2 KDM2A-2 ENSPTRP00000069792 ENSPTRP00000069792 ENSPTRP00000069894 ENSPTRP00000069894 MAPK10 MAPK10 SFPQ SFPQ PER2 PER2 PDE6B PDE6B NR1D2 NR1D2 NKX2-1 NKX2-1 GHRHR-2 GHRHR-2 GNA11 GNA11 PPP1CC-2 PPP1CC-2 LOC454204 LOC454204 NOCT NOCT CK820_G0034985 CK820_G0034985 ENSPTRP00000075783 ENSPTRP00000075783 USP7 USP7 ENSPTRP00000076468 ENSPTRP00000076468 PPARG PPARG BTRC BTRC UBE3A UBE3A EZH2 EZH2 ENSPTRP00000077377 ENSPTRP00000077377 PPP1CC PPP1CC MAGED1 MAGED1 GHRL GHRL CRY2 CRY2 FBXW11 FBXW11 FBXL21P FBXL21P OPN4 OPN4 NR1H3 NR1H3 CIPC CIPC ATG7 ATG7 ARNTL2 ARNTL2 FBXL22 FBXL22 GSK3B GSK3B DDB1 DDB1 MTA1 MTA1 RORC RORC FBXL17 FBXL17 ENSPTRP00000083257 ENSPTRP00000083257 ENSPTRP00000083600 ENSPTRP00000083600 ENSPTRP00000084126 ENSPTRP00000084126 LOC748739 LOC748739 RORA RORA HNF4A HNF4A ENSPTRP00000088792 ENSPTRP00000088792 CSNK1E CSNK1E EZH2-2 EZH2-2 ENSPTRP00000091943 ENSPTRP00000091943 SUV39H1-2 SUV39H1-2 ENSPTRP00000093040 ENSPTRP00000093040 SOX14 SOX14
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BHLHE40Basic helix-loop-helix family, member e40. (412 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
THRAP3Thyroid hormone receptor associated protein 3. (955 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
CHRNB2CHRNB2 isoform 2. (502 aa)
OPN3CHML isoform 2. (402 aa)
ATOH7Atonal bHLH transcription factor 7. (152 aa)
ADRB1Adrenoceptor beta 1. (476 aa)
DRD4DRD4 isoform 1; Belongs to the G-protein coupled receptor 1 family. (415 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (513 aa)
RBM4BRBM4B isoform 1. (359 aa)
KDM2ALysine (K)-specific demethylase 2A. (1162 aa)
USP2Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (605 aa)
CRY1Cryptochrome circadian regulator 1. (586 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (455 aa)
PSPC1Paraspeckle component 1. (508 aa)
PMLPML isoform 6. (836 aa)
FBXL8T0157855 isoform 2. (374 aa)
ZFHX3Zinc finger homeobox 3. (3688 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
NR1D1Nuclear receptor subfamily 1, group D, member 1. (614 aa)
TOP2ADNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1531 aa)
PHLPP1PH domain and leucine rich repeat protein phosphatase 1. (1719 aa)
SIRT6SIRT6 isoform 1. (355 aa)
FBXL12F-box and leucine-rich repeat protein 12. (326 aa)
NR2F6Nuclear receptor subfamily 2 group F member 6. (401 aa)
CRTC1CRTC1 isoform 1. (648 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
ID2Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein. (134 aa)
GHRHGrowth hormone releasing hormone. (108 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (412 aa)
SRRDSRR1 domain containing. (325 aa)
PPARAPeroxisome proliferator-activated receptor alpha. (467 aa)
SPSB4SplA/ryanodine receptor domain and SOCS box containing 4. (273 aa)
SIAH2E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (324 aa)
PPARGC1APPARG coactivator 1 alpha. (809 aa)
CLOCKClock circadian regulator. (847 aa)
HNRNPDHNRNPD isoform 1. (356 aa)
FBXW7F-box and WD repeat domain containing 7. (707 aa)
CSF2Colony stimulating factor 2. (144 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
HCRTR2Hypocretin receptor 2; Belongs to the G-protein coupled receptor 1 family. (444 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
CCAR2Cell cycle and apoptosis regulator 2. (923 aa)
CRHCorticotropin releasing hormone. (196 aa)
FBXL6F-box and leucine-rich repeat protein 6. (539 aa)
PTGDSProstaglandin D2 synthase 21kDa (Brain); Belongs to the calycin superfamily. Lipocalin family. (190 aa)
SUV39H1Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (423 aa)
NONOnon-POU domain containing octamer binding. (471 aa)
PASD1PAS domain containing repressor 1. (784 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
TIMELESSTimeless circadian regulator. (1209 aa)
PER3Period circadian regulator 3. (1191 aa)
FBXL3F-box and leucine-rich repeat protein 3. (428 aa)
PRKDCProtein kinase, DNA-activated, catalytic polypeptide; Belongs to the PI3/PI4-kinase family. (4128 aa)
SIN3ASIN3 transcription regulator family member A. (1273 aa)
MTNR1BMelatonin receptor 1B; Belongs to the G-protein coupled receptor 1 family. (362 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
GNAQGuanine nucleotide binding protein (G protein), q polypeptide. (359 aa)
CDK1Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
PROX1Prospero homeobox 1. (737 aa)
NPSNeuropeptide S. (89 aa)
KLF10Kruppel-like factor 10. (480 aa)
NLGN1NLGN1 isoform 1. (823 aa)
OPN5OPN5 isoform 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
RORBRAR related orphan receptor B. (482 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
FBXW9F-box and WD repeat domain containing 9. (478 aa)
GHRHRGrowth hormone releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family. (423 aa)
PER1Period circadian regulator 1. (1290 aa)
MAGEL2MAGEL2 isoform 1. (1249 aa)
ADCY1-2Adenylate cyclase 1. (1119 aa)
CSNK1DCasein kinase 1 delta; Belongs to the protein kinase superfamily. (427 aa)
ARNTLAryl hydrocarbon receptor nuclear translocator-like. (628 aa)
SUV39H2Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (410 aa)
PIWIL2Piwi-like RNA-mediated gene silencing 2; Belongs to the argonaute family. (973 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (331 aa)
USP9XUbiquitin specific peptidase 9, X-linked; Belongs to the peptidase C19 family. (2591 aa)
ENSPTRP00000068968annotation not available (60 aa)
KDM2A-2Lysine demethylase 2A. (1162 aa)
ENSPTRP00000069792annotation not available (651 aa)
ENSPTRP00000069894annotation not available (299 aa)
MAPK10Mitogen-activated protein kinase. (551 aa)
SFPQSplicing factor proline/glutamine-rich. (677 aa)
PER2Period circadian regulator 2. (1255 aa)
PDE6BPDE6B isoform 6. (747 aa)
NR1D2Nuclear receptor subfamily 1, group D, member 2. (580 aa)
NKX2-1NKX2-1 isoform 1. (401 aa)
GHRHR-2Growth hormone-releasing hormone receptor isoform X1. (447 aa)
GNA11Guanine nucleotide binding protein (G protein), alpha 11 (Gq class). (359 aa)
PPP1CC-2Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (333 aa)
LOC454204Non-POU domain-containing octamer-binding protein. (445 aa)
NOCTCCR4 carbon catabolite repression 4-like. (431 aa)
CK820_G0034985TARDBP isoform 25. (246 aa)
ENSPTRP00000075783annotation not available (149 aa)
USP7Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1121 aa)
ENSPTRP00000076468annotation not available (140 aa)
PPARGPeroxisome proliferator-activated receptor gamma isoform X2. (505 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (875 aa)
EZH2Enhancer of zeste homolog 2. (754 aa)
ENSPTRP00000077377annotation not available (149 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (341 aa)
MAGED1MAGE family member D1. (834 aa)
GHRLGHRL isoform 10. (117 aa)
CRY2Cryptochrome circadian regulator 2. (614 aa)
FBXW11F-box and WD repeat domain containing 11. (563 aa)
FBXL21PF-box and leucine-rich repeat protein 21. (432 aa)
OPN4OPN4 isoform 3. (495 aa)
NR1H3Nuclear receptor subfamily 1 group H member 3. (453 aa)
CIPCT0010188 isoform 1. (399 aa)
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (704 aa)
ARNTL2Aryl hydrocarbon receptor nuclear translocator like 2. (635 aa)
FBXL22F-box and leucine rich repeat protein 22. (247 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (481 aa)
DDB1Damage-specific DNA binding protein 1, 127kDa. (1147 aa)
MTA1Metastasis associated 1. (743 aa)
RORCRAR related orphan receptor C. (525 aa)
FBXL17F-box and leucine rich repeat protein 17. (715 aa)
ENSPTRP00000083257annotation not available (412 aa)
ENSPTRP00000083600annotation not available (784 aa)
ENSPTRP00000084126annotation not available (117 aa)
LOC748739NR2F6 isoform 1. (404 aa)
RORARAR-related orphan receptor A. (555 aa)
HNF4AHepatocyte nuclear factor 4 alpha. (474 aa)
ENSPTRP00000088792annotation not available (228 aa)
CSNK1ECasein kinase 1, epsilon; Belongs to the protein kinase superfamily. (419 aa)
EZH2-2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (751 aa)
ENSPTRP00000091943annotation not available (539 aa)
SUV39H1-2Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (412 aa)
ENSPTRP00000093040annotation not available (289 aa)
SOX14SOX14 isoform 1. (240 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: low (22%) [HD]