36 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	EP300	E1A binding protein p300. (2175 aa)
	BBC3	BCL2 binding component 3. (270 aa)
	ENSPTRP00000081714	annotation not available (310 aa)
	SHISA5	Shisa family member 5. (248 aa)
	BBC3-2	BCL2 binding component 3. (270 aa)
	PHLDA3	Pleckstrin homology like domain family A member 3. (127 aa)
	USP28	USP28 isoform 2; Belongs to the peptidase C19 family. (1192 aa)
	ATAD5	ATPase family AAA domain containing 5. (1844 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
	PYCARD	PYD and CARD domain containing. (195 aa)
	CK820_G0024820	PPP2R5C isoform 26. (479 aa)
	RPS27L	40S ribosomal protein S27. (100 aa)
	SIRT1-2	Sirtuin 1. (751 aa)
	NUPR1	Nuclear protein 1, transcriptional regulator. (82 aa)
	HIPK1	HIPK1 isoform 10. (1210 aa)
	SIRT1	SIRT1 isoform 2. (751 aa)
	DDIT4	DNA-damage-inducible transcript 4. (232 aa)
	TMEM109	Transmembrane protein 109. (243 aa)
	BRCA2	Breast cancer 2, early onset. (3418 aa)
	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (579 aa)
	ELL3	Elongation factor RNA polymerase II-like 3. (397 aa)
	PML	PML isoform 6. (836 aa)
	CHEK2	Checkpoint kinase 2. (586 aa)
	MSH2	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (865 aa)
	BAG6	BAG6 isoform 3. (1162 aa)
	DYRK2	Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2. (601 aa)
	IFI16	IFI16 isoform 4. (733 aa)
	TP73	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (636 aa)
	SNW1	SNW domain containing 1. (571 aa)
	CDKN1A	Cyclin-dependent kinase inhibitor 1A (P21, Cip1). (276 aa)
	AEN	Apoptosis enhancing nuclease. (325 aa)
	TOPORS	Topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase. (1045 aa)
	BCL3	BCL3 transcription coactivator. (454 aa)
	CDIP1	Chromosome 16 open reading frame 5. (208 aa)
	HIPK2	Homeodomain interacting protein kinase 2. (1198 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AEN	PHLDA3	ENSPTRP00000051293	ENSPTRP00000083933	Apoptosis enhancing nuclease.	Pleckstrin homology like domain family A member 3.	0.459
ATAD5	BRCA2	ENSPTRP00000015300	ENSPTRP00000009812	ATPase family AAA domain containing 5.	Breast cancer 2, early onset.	0.670
ATAD5	CHEK2	ENSPTRP00000015300	ENSPTRP00000067666	ATPase family AAA domain containing 5.	Checkpoint kinase 2.	0.561
BBC3	CDKN1A	ENSPTRP00000076073	ENSPTRP00000060292	BCL2 binding component 3.	Cyclin-dependent kinase inhibitor 1A (P21, Cip1).	0.608
BBC3	TP53	ENSPTRP00000076073	ENSPTRP00000014836	BCL2 binding component 3.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.698
BBC3	TP73	ENSPTRP00000076073	ENSPTRP00000064772	BCL2 binding component 3.	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.	0.481
BBC3-2	CDKN1A	ENSPTRP00000083217	ENSPTRP00000060292	BCL2 binding component 3.	Cyclin-dependent kinase inhibitor 1A (P21, Cip1).	0.608
BBC3-2	TP53	ENSPTRP00000083217	ENSPTRP00000014836	BCL2 binding component 3.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.698
BBC3-2	TP73	ENSPTRP00000083217	ENSPTRP00000064772	BCL2 binding component 3.	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.	0.481
BRCA2	ATAD5	ENSPTRP00000009812	ENSPTRP00000015300	Breast cancer 2, early onset.	ATPase family AAA domain containing 5.	0.670
BRCA2	CDKN1A	ENSPTRP00000009812	ENSPTRP00000060292	Breast cancer 2, early onset.	Cyclin-dependent kinase inhibitor 1A (P21, Cip1).	0.470
BRCA2	CHEK2	ENSPTRP00000009812	ENSPTRP00000067666	Breast cancer 2, early onset.	Checkpoint kinase 2.	0.896
BRCA2	MSH2	ENSPTRP00000009812	ENSPTRP00000066383	Breast cancer 2, early onset.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.874
BRCA2	TP53	ENSPTRP00000009812	ENSPTRP00000014836	Breast cancer 2, early onset.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.967
BRCA2	TP63	ENSPTRP00000009812	ENSPTRP00000027067	Breast cancer 2, early onset.	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.	0.454
BRCA2	TP73	ENSPTRP00000009812	ENSPTRP00000064772	Breast cancer 2, early onset.	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.	0.454
CDKN1A	BBC3	ENSPTRP00000060292	ENSPTRP00000076073	Cyclin-dependent kinase inhibitor 1A (P21, Cip1).	BCL2 binding component 3.	0.608
CDKN1A	BBC3-2	ENSPTRP00000060292	ENSPTRP00000083217	Cyclin-dependent kinase inhibitor 1A (P21, Cip1).	BCL2 binding component 3.	0.608
CDKN1A	BRCA2	ENSPTRP00000060292	ENSPTRP00000009812	Cyclin-dependent kinase inhibitor 1A (P21, Cip1).	Breast cancer 2, early onset.	0.470
CDKN1A	CHEK2	ENSPTRP00000060292	ENSPTRP00000067666	Cyclin-dependent kinase inhibitor 1A (P21, Cip1).	Checkpoint kinase 2.	0.545