(24 nodes) Cytoplasmic sequestering of transcription factor network (Pan troglodytes)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NFKBIE	NFKB inhibitor epsilon. (500 aa)
	CK820_G0029100	SRI isoform 2. (98 aa)
	ENSPTRP00000085680	annotation not available (88 aa)
	CK820_G0054628	PKD1 isoform 4. (3384 aa)
	FAF1	Fas (TNFRSF6) associated factor 1. (650 aa)
	SRI-2	SRI isoform 5. (237 aa)
	SRI	SRI isoform 1. (205 aa)
	ENSPTRP00000077985	annotation not available (153 aa)
	SUFU	Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (519 aa)
	ENSPTRP00000073673	annotation not available (196 aa)
	ENSPTRP00000069497	annotation not available (53 aa)
	MDFI-2	MyoD family inhibitor. (246 aa)
	CK820_G0056924	NPIPA2 isoform 1. (277 aa)
	NFKBIB	NFKB inhibitor beta. (270 aa)
	CREB3	cAMP responsive element binding protein 3. (371 aa)
	TMSB4X	Thymosin beta 4 X-linked. (44 aa)
	PSMD10	Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 10. (226 aa)
	G3BP2	GTPase activating protein (SH3 domain) binding protein 2. (482 aa)
	CCDC22	Coiled-coil domain containing 22. (627 aa)
	MDFI	MyoD family inhibitor. (246 aa)
	PKD2	Polycystin 2, transient receptor potential cation channel. (968 aa)
	KEAP1	Kelch-like ECH-associated protein 1. (624 aa)
	NFKBIA	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha. (317 aa)
	TMSB4X-2	Thymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (54 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CK820_G0054628	CK820_G0056924	ENSPTRP00000083743	ENSPTRP00000064672	PKD1 isoform 4.	NPIPA2 isoform 1.	0.444
CK820_G0054628	PKD2	ENSPTRP00000083743	ENSPTRP00000027941	PKD1 isoform 4.	Polycystin 2, transient receptor potential cation channel.	0.997
CK820_G0056924	CK820_G0054628	ENSPTRP00000064672	ENSPTRP00000083743	NPIPA2 isoform 1.	PKD1 isoform 4.	0.444
CK820_G0056924	PKD2	ENSPTRP00000064672	ENSPTRP00000027941	NPIPA2 isoform 1.	Polycystin 2, transient receptor potential cation channel.	0.962
CREB3	KEAP1	ENSPTRP00000049324	ENSPTRP00000017850	cAMP responsive element binding protein 3.	Kelch-like ECH-associated protein 1.	0.469
ENSPTRP00000073673	NFKBIA	ENSPTRP00000073673	ENSPTRP00000010634	annotation not available	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha.	0.585
ENSPTRP00000073673	NFKBIB	ENSPTRP00000073673	ENSPTRP00000058822	annotation not available	NFKB inhibitor beta.	0.404
ENSPTRP00000073673	NFKBIE	ENSPTRP00000073673	ENSPTRP00000031139	annotation not available	NFKB inhibitor epsilon.	0.577
ENSPTRP00000077985	NFKBIA	ENSPTRP00000077985	ENSPTRP00000010634	annotation not available	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha.	0.459
ENSPTRP00000077985	NFKBIE	ENSPTRP00000077985	ENSPTRP00000031139	annotation not available	NFKB inhibitor epsilon.	0.454
G3BP2	NFKBIA	ENSPTRP00000040810	ENSPTRP00000010634	GTPase activating protein (SH3 domain) binding protein 2.	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha.	0.530
KEAP1	CREB3	ENSPTRP00000017850	ENSPTRP00000049324	Kelch-like ECH-associated protein 1.	cAMP responsive element binding protein 3.	0.469
KEAP1	NFKBIA	ENSPTRP00000017850	ENSPTRP00000010634	Kelch-like ECH-associated protein 1.	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha.	0.417
NFKBIA	ENSPTRP00000073673	ENSPTRP00000010634	ENSPTRP00000073673	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha.	annotation not available	0.585
NFKBIA	ENSPTRP00000077985	ENSPTRP00000010634	ENSPTRP00000077985	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha.	annotation not available	0.459
NFKBIA	G3BP2	ENSPTRP00000010634	ENSPTRP00000040810	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha.	GTPase activating protein (SH3 domain) binding protein 2.	0.530
NFKBIA	KEAP1	ENSPTRP00000010634	ENSPTRP00000017850	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha.	Kelch-like ECH-associated protein 1.	0.417
NFKBIA	NFKBIB	ENSPTRP00000010634	ENSPTRP00000058822	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha.	NFKB inhibitor beta.	0.997
NFKBIA	NFKBIE	ENSPTRP00000010634	ENSPTRP00000031139	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha.	NFKB inhibitor epsilon.	0.979
NFKBIB	ENSPTRP00000073673	ENSPTRP00000058822	ENSPTRP00000073673	NFKB inhibitor beta.	annotation not available	0.404