(26 nodes) Myeloid dendritic cell differentiation network (Pan troglodytes)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	NOTCH2	NOTCH2 isoform 1. (2612 aa)
	ITGB6	ITGB6 isoform 3. (701 aa)
	IL4-2	Interleukin 4. (153 aa)
	ENSPTRP00000071088	annotation not available (500 aa)
	ENSPTRP00000065244	annotation not available (463 aa)
	GIMAP1	GTPase IMAP family member 5. (500 aa)
	DCSTAMP	Dendrocyte expressed seven transmembrane protein. (470 aa)
	UBD	UBD isoform 1. (165 aa)
	BATF3	Basic leucine zipper ATF-like transcription factor 3. (123 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
	BATF2	Basic leucine zipper ATF-like transcription factor 2. (274 aa)
	LTBR	Lymphotoxin beta receptor (TNFR superfamily, member 3). (435 aa)
	PSEN1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
	BATF	Basic leucine zipper ATF-like transcription factor. (125 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	CAMK4	Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (473 aa)
	CSF2	Colony stimulating factor 2. (144 aa)
	IL4	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4. (153 aa)
	IRF4	Interferon regulatory factor 4. (451 aa)
	RELB	RELB isoform 3. (567 aa)
	DHRS2	DHRS2 isoform 3. (280 aa)
	ITGB8-2	Integrin subunit beta 8. (780 aa)
	SPI1	Spi-1 proto-oncogene. (270 aa)
	ITGB8	Integrin beta; Belongs to the integrin beta chain family. (780 aa)
	RBPJ	Recombination signal binding protein for immunoglobulin kappa J region. (500 aa)
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (581 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BATF	BATF2	ENSPTRP00000011135	ENSPTRP00000006643	Basic leucine zipper ATF-like transcription factor.	Basic leucine zipper ATF-like transcription factor 2.	0.910
BATF	BATF3	ENSPTRP00000011135	ENSPTRP00000003308	Basic leucine zipper ATF-like transcription factor.	Basic leucine zipper ATF-like transcription factor 3.	0.917
BATF	IRF4	ENSPTRP00000011135	ENSPTRP00000030162	Basic leucine zipper ATF-like transcription factor.	Interferon regulatory factor 4.	0.907
BATF	SPI1	ENSPTRP00000011135	ENSPTRP00000084012	Basic leucine zipper ATF-like transcription factor.	Spi-1 proto-oncogene.	0.585
BATF2	BATF	ENSPTRP00000006643	ENSPTRP00000011135	Basic leucine zipper ATF-like transcription factor 2.	Basic leucine zipper ATF-like transcription factor.	0.910
BATF2	BATF3	ENSPTRP00000006643	ENSPTRP00000003308	Basic leucine zipper ATF-like transcription factor 2.	Basic leucine zipper ATF-like transcription factor 3.	0.907
BATF3	BATF	ENSPTRP00000003308	ENSPTRP00000011135	Basic leucine zipper ATF-like transcription factor 3.	Basic leucine zipper ATF-like transcription factor.	0.917
BATF3	BATF2	ENSPTRP00000003308	ENSPTRP00000006643	Basic leucine zipper ATF-like transcription factor 3.	Basic leucine zipper ATF-like transcription factor 2.	0.907
BATF3	IRF4	ENSPTRP00000003308	ENSPTRP00000030162	Basic leucine zipper ATF-like transcription factor 3.	Interferon regulatory factor 4.	0.667
BATF3	NOTCH2	ENSPTRP00000003308	ENSPTRP00000075807	Basic leucine zipper ATF-like transcription factor 3.	NOTCH2 isoform 1.	0.401
CSF2	IL4	ENSPTRP00000029448	ENSPTRP00000029464	Colony stimulating factor 2.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4.	0.819
CSF2	IL4-2	ENSPTRP00000029448	ENSPTRP00000071542	Colony stimulating factor 2.	Interleukin 4.	0.819
CSF2	IRF4	ENSPTRP00000029448	ENSPTRP00000030162	Colony stimulating factor 2.	Interferon regulatory factor 4.	0.400
CSF2	SPI1	ENSPTRP00000029448	ENSPTRP00000084012	Colony stimulating factor 2.	Spi-1 proto-oncogene.	0.569
CSF2	TGFB1	ENSPTRP00000029448	ENSPTRP00000018930	Colony stimulating factor 2.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.551
DCSTAMP	TRAF6	ENSPTRP00000035052	ENSPTRP00000006096	Dendrocyte expressed seven transmembrane protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.459
ENSPTRP00000065244	IRF4	ENSPTRP00000065244	ENSPTRP00000030162	annotation not available	Interferon regulatory factor 4.	0.408
ENSPTRP00000065244	LTBR	ENSPTRP00000065244	ENSPTRP00000007817	annotation not available	Lymphotoxin beta receptor (TNFR superfamily, member 3).	0.408
ENSPTRP00000065244	PSEN1	ENSPTRP00000065244	ENSPTRP00000011045	annotation not available	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.529
ENSPTRP00000065244	RELB	ENSPTRP00000065244	ENSPTRP00000088356	annotation not available	RELB isoform 3.	0.538