46 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TNFSF14	Tumor necrosis factor ligand 1D; Belongs to the tumor necrosis factor family. (240 aa)
	ZC3H8	Zinc finger CCCH-type containing 8. (291 aa)
	SIT1	Signaling threshold regulating transmembrane adaptor 1. (196 aa)
	SLC46A2	Solute carrier family 46 member 2. (475 aa)
	RC3H2	Ring finger and CCCH-type domains 2. (1191 aa)
	FOXP3	FOXP3 isoform 4. (456 aa)
	JAK3	Tyrosine-protein kinase. (1124 aa)
	GIMAP1	GTPase IMAP family member 5. (500 aa)
	P2RX7	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
	CASP3	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. (277 aa)
	CK820_G0015936	C12orf76 isoform 1. (107 aa)
	GPR174	G protein-coupled receptor 174. (333 aa)
	RPS6	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
	ENSPTRP00000061568	annotation not available (353 aa)
	ENSPTRP00000062821	annotation not available (220 aa)
	RAG1	V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (955 aa)
	PPP3CB	Serine/threonine-protein phosphatase. (526 aa)
	ENSPTRP00000066724	annotation not available (166 aa)
	DNAJA3	DnaJ heat shock protein family (Hsp40) member A3. (480 aa)
	RC3H1	Ring finger and CCCH-type domains 1. (1134 aa)
	IL2RA	Interleukin-2 receptor subunit alpha; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. (272 aa)
	GPAM	Glycerol-3-phosphate acyltransferase 1, mitochondrial. (828 aa)
	TCIRG1	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (830 aa)
	FADD	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
	NCKAP1L	NCK associated protein 1 like. (1127 aa)
	RIPK3	Receptor interacting serine/threonine kinase 3. (518 aa)
	PPP2R3C	Protein phosphatase 2, regulatory subunit B'', gamma. (453 aa)
	SIVA1	Apoptosis regulatory protein Siva; Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl- x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis. (175 aa)
	CCNB2	CCNB2 isoform 1; Belongs to the cyclin family. (398 aa)
	CORO1A	Coronin; Belongs to the WD repeat coronin family. (461 aa)
	SPNS2	Sphingolipid transporter 2. (548 aa)
	FOXN1	FOXN1 isoform 2. (648 aa)
	PRDX2	PRDX2 isoform 1. (198 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	ENSPTRP00000071088	annotation not available (500 aa)
	ENSPTRP00000074403	annotation not available (115 aa)
	IL7R	Interleukin 7 receptor. (459 aa)
	BCL2L11	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
	ENSPTRP00000079023	annotation not available (237 aa)
	ENSPTRP00000081143	annotation not available (219 aa)
	AKT1	AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa)
	LGALS2	Galectin. (136 aa)
	FAS	Fas (TNF receptor superfamily, member 6). (337 aa)
	STAT5B	Signal transducer and activator of transcription. (772 aa)
	BCL2	BCL2 apoptosis regulator. (239 aa)
	BAX	BAX isoform 7. (123 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1	BCL2	ENSPTRP00000082849	ENSPTRP00000090293	AKT1 isoform 3; Belongs to the protein kinase superfamily.	BCL2 apoptosis regulator.	0.969
AKT1	BCL2L11	ENSPTRP00000082849	ENSPTRP00000076253	AKT1 isoform 3; Belongs to the protein kinase superfamily.	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family.	0.614
AKT1	CASP3	ENSPTRP00000082849	ENSPTRP00000054330	AKT1 isoform 3; Belongs to the protein kinase superfamily.	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	0.821
AKT1	ENSPTRP00000066724	ENSPTRP00000082849	ENSPTRP00000066724	AKT1 isoform 3; Belongs to the protein kinase superfamily.	annotation not available	0.402
AKT1	FADD	ENSPTRP00000082849	ENSPTRP00000006883	AKT1 isoform 3; Belongs to the protein kinase superfamily.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.461
AKT1	FAS	ENSPTRP00000082849	ENSPTRP00000088261	AKT1 isoform 3; Belongs to the protein kinase superfamily.	Fas (TNF receptor superfamily, member 6).	0.489
AKT1	FOXP3	ENSPTRP00000082849	ENSPTRP00000037587	AKT1 isoform 3; Belongs to the protein kinase superfamily.	FOXP3 isoform 4.	0.469
AKT1	IL7R	ENSPTRP00000082849	ENSPTRP00000075860	AKT1 isoform 3; Belongs to the protein kinase superfamily.	Interleukin 7 receptor.	0.444
AKT1	PPP2R3C	ENSPTRP00000082849	ENSPTRP00000010629	AKT1 isoform 3; Belongs to the protein kinase superfamily.	Protein phosphatase 2, regulatory subunit B'', gamma.	0.656
AKT1	PPP3CB	ENSPTRP00000082849	ENSPTRP00000064667	AKT1 isoform 3; Belongs to the protein kinase superfamily.	Serine/threonine-protein phosphatase.	0.401
AKT1	PRDX2	ENSPTRP00000082849	ENSPTRP00000017998	AKT1 isoform 3; Belongs to the protein kinase superfamily.	PRDX2 isoform 1.	0.402
AKT1	STAT5B	ENSPTRP00000082849	ENSPTRP00000089134	AKT1 isoform 3; Belongs to the protein kinase superfamily.	Signal transducer and activator of transcription.	0.674
AKT1	TGFB1	ENSPTRP00000082849	ENSPTRP00000018930	AKT1 isoform 3; Belongs to the protein kinase superfamily.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.717
BAX	BCL2	ENSPTRP00000092787	ENSPTRP00000090293	BAX isoform 7.	BCL2 apoptosis regulator.	0.971
BAX	BCL2L11	ENSPTRP00000092787	ENSPTRP00000076253	BAX isoform 7.	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family.	0.986
BAX	CASP3	ENSPTRP00000092787	ENSPTRP00000054330	BAX isoform 7.	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	0.588
BCL2	AKT1	ENSPTRP00000090293	ENSPTRP00000082849	BCL2 apoptosis regulator.	AKT1 isoform 3; Belongs to the protein kinase superfamily.	0.969
BCL2	BAX	ENSPTRP00000090293	ENSPTRP00000092787	BCL2 apoptosis regulator.	BAX isoform 7.	0.971
BCL2	BCL2L11	ENSPTRP00000090293	ENSPTRP00000076253	BCL2 apoptosis regulator.	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family.	0.999
BCL2	CASP3	ENSPTRP00000090293	ENSPTRP00000054330	BCL2 apoptosis regulator.	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	0.895