(11 nodes) Neurotrophin binding network (Pan troglodytes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HAP1	HAP1 isoform 2. (667 aa)
	NTF3	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (275 aa)
	NTRK2	Tyrosine-protein kinase receptor. (838 aa)
	A2M	Alpha-2-macroglobulin. (1474 aa)
	PCSK6	PCSK6 isoform 3; Belongs to the peptidase S8 family. (968 aa)
	FSTL4	Follistatin like 4. (842 aa)
	NGFR	Nerve growth factor receptor. (427 aa)
	NTRK1	Tyrosine-protein kinase receptor. (796 aa)
	NTRK3	NT-3 growth factor receptor; Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation. (864 aa)
	SORT1	SORT1 isoform 2. (831 aa)
	FURIN	Furin (Paired basic amino acid cleaving enzyme); Belongs to the peptidase S8 family. (794 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A2M	FURIN	ENSPTRP00000056596	ENSPTRP00000012755	Alpha-2-macroglobulin.	Furin (Paired basic amino acid cleaving enzyme); Belongs to the peptidase S8 family.	0.426
FURIN	A2M	ENSPTRP00000012755	ENSPTRP00000056596	Furin (Paired basic amino acid cleaving enzyme); Belongs to the peptidase S8 family.	Alpha-2-macroglobulin.	0.426
FURIN	PCSK6	ENSPTRP00000012755	ENSPTRP00000046526	Furin (Paired basic amino acid cleaving enzyme); Belongs to the peptidase S8 family.	PCSK6 isoform 3; Belongs to the peptidase S8 family.	0.433
FURIN	SORT1	ENSPTRP00000012755	ENSPTRP00000001807	Furin (Paired basic amino acid cleaving enzyme); Belongs to the peptidase S8 family.	SORT1 isoform 2.	0.567
HAP1	NTRK2	ENSPTRP00000015630	ENSPTRP00000077403	HAP1 isoform 2.	Tyrosine-protein kinase receptor.	0.483
HAP1	SORT1	ENSPTRP00000015630	ENSPTRP00000001807	HAP1 isoform 2.	SORT1 isoform 2.	0.542
NGFR	NTF3	ENSPTRP00000015928	ENSPTRP00000089931	Nerve growth factor receptor.	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family.	0.991
NGFR	NTRK1	ENSPTRP00000015928	ENSPTRP00000083380	Nerve growth factor receptor.	Tyrosine-protein kinase receptor.	0.974
NGFR	NTRK2	ENSPTRP00000015928	ENSPTRP00000077403	Nerve growth factor receptor.	Tyrosine-protein kinase receptor.	0.869
NGFR	NTRK3	ENSPTRP00000015928	ENSPTRP00000085547	Nerve growth factor receptor.	NT-3 growth factor receptor; Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation.	0.861
NGFR	SORT1	ENSPTRP00000015928	ENSPTRP00000001807	Nerve growth factor receptor.	SORT1 isoform 2.	0.994
NTF3	NGFR	ENSPTRP00000089931	ENSPTRP00000015928	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family.	Nerve growth factor receptor.	0.991
NTF3	NTRK1	ENSPTRP00000089931	ENSPTRP00000083380	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family.	Tyrosine-protein kinase receptor.	0.980
NTF3	NTRK2	ENSPTRP00000089931	ENSPTRP00000077403	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family.	Tyrosine-protein kinase receptor.	0.979
NTF3	NTRK3	ENSPTRP00000089931	ENSPTRP00000085547	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family.	NT-3 growth factor receptor; Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation.	0.987
NTF3	SORT1	ENSPTRP00000089931	ENSPTRP00000001807	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family.	SORT1 isoform 2.	0.548
NTRK1	NGFR	ENSPTRP00000083380	ENSPTRP00000015928	Tyrosine-protein kinase receptor.	Nerve growth factor receptor.	0.974
NTRK1	NTF3	ENSPTRP00000083380	ENSPTRP00000089931	Tyrosine-protein kinase receptor.	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family.	0.980
NTRK1	NTRK2	ENSPTRP00000083380	ENSPTRP00000077403	Tyrosine-protein kinase receptor.	Tyrosine-protein kinase receptor.	0.862
NTRK1	NTRK3	ENSPTRP00000083380	ENSPTRP00000085547	Tyrosine-protein kinase receptor.	NT-3 growth factor receptor; Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation.	0.622