STRINGSTRING
OTUD7A OTUD7A PPM1A PPM1A NLRX1 NLRX1 SIRT1 SIRT1 ASH1L ASH1L OTUD7B OTUD7B NLRP6 NLRP6 RORA RORA LOC104001961 LOC104001961 PPM1N PPM1N USP10 USP10 TNIP1 TNIP1 HDAC1 HDAC1 ABL1 ABL1 NR1H4 NR1H4 LILRB4 LILRB4 MAPKBP1 MAPKBP1 ZC3H12A ZC3H12A ENSPTRP00000068326 ENSPTRP00000068326 CARD8 CARD8 DNAJA3 DNAJA3 LOC748850 LOC748850 PER1 PER1 ENSPTRP00000063212 ENSPTRP00000063212 RHOH RHOH TANK TANK CARD19 CARD19 SIRT1-2 SIRT1-2 RIOK3 RIOK3 STAT1 STAT1 NLRP12 NLRP12 ZMYND11 ZMYND11 CK820_G0012168 CK820_G0012168 DAB2IP DAB2IP RPP21 RPP21 GSTP1 GSTP1 TLE1 TLE1 OPTN OPTN CCDC22 CCDC22 ESR1 ESR1 TNFAIP3 TNFAIP3 TREM2 TREM2 RIPK1 RIPK1 TNIP3 TNIP3 ADIPOQ ADIPOQ RHOA RHOA CASP8 CASP8 PPM1B PPM1B CACTIN CACTIN NR1D1 NR1D1 PYCARD PYCARD NLRC3 NLRC3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
OTUD7AOTU deubiquitinase 7A. (924 aa)
PPM1AProtein phosphatase, Mg2+/Mn2+ dependent 1A. (455 aa)
NLRX1NLRX1 isoform 1. (975 aa)
SIRT1SIRT1 isoform 2. (751 aa)
ASH1LASH1 like histone lysine methyltransferase. (2969 aa)
OTUD7BOTU domain containing 7B. (843 aa)
NLRP6NLR family pyrin domain containing 6. (892 aa)
RORARAR-related orphan receptor A. (555 aa)
LOC104001961USP10 isoform 3. (709 aa)
PPM1NProtein phosphatase, Mg2+/Mn2+ dependent 1N (putative). (430 aa)
USP10Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (802 aa)
TNIP1TNIP1 isoform 12. (645 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
NR1H4Nuclear receptor subfamily 1 group H member 4. (486 aa)
LILRB4LILRB4 isoform 7. (449 aa)
MAPKBP1Mitogen-activated protein kinase binding protein 1. (1514 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (599 aa)
ENSPTRP00000068326annotation not available (488 aa)
CARD8Caspase recruitment domain family member 8. (537 aa)
DNAJA3DnaJ heat shock protein family (Hsp40) member A3. (480 aa)
LOC748850HDAC2 isoform 9. (445 aa)
PER1Period circadian regulator 1. (1290 aa)
ENSPTRP00000063212annotation not available (75 aa)
RHOHRHOH isoform 10. (191 aa)
TANKTANK isoform 1. (483 aa)
CARD19CARD19 isoform 3. (246 aa)
SIRT1-2Sirtuin 1. (751 aa)
RIOK3Serine/threonine-protein kinase RIO3; Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. (606 aa)
STAT1Signal transducer and activator of transcription. (758 aa)
NLRP12NLRP12 isoform 1. (1060 aa)
ZMYND11Zinc finger, MYND-type containing 11. (648 aa)
CK820_G0012168ABL1 isoform 3. (1149 aa)
DAB2IPDAB2 interacting protein. (1189 aa)
RPP21E3 ubiquitin-protein ligase TRIM39; E3 ubiquitin-protein ligase (By similarity). May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1 (By similarity). Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21 (By similarity). Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation (By similari [...] (518 aa)
GSTP1Glutathione S-transferase pi 1; Belongs to the GST superfamily. (210 aa)
TLE1Transducin-like enhancer of split 1. (814 aa)
OPTNOPTN isoform 1. (577 aa)
CCDC22Coiled-coil domain containing 22. (627 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
TNFAIP3Tumor necrosis factor, alpha-induced protein 3. (790 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
RIPK1Receptor (TNFRSF)-interacting serine-threonine kinase 1. (671 aa)
TNIP3TNFAIP3 interacting protein 3. (376 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
RHOARas homolog family member A. (193 aa)
CASP8Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (538 aa)
PPM1BProtein phosphatase, Mg2+/Mn2+ dependent, 1B. (479 aa)
CACTINCactin, spliceosome C complex subunit. (756 aa)
NR1D1Nuclear receptor subfamily 1, group D, member 1. (614 aa)
PYCARDPYD and CARD domain containing. (195 aa)
NLRC3NLRC3 isoform 4. (1112 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.