STRINGSTRING
YARS2 YARS2 P3H3 P3H3 P4HA3 P4HA3 FOLR1 FOLR1 FOLR3 FOLR3 STX3 STX3 PPARD PPARD ALKBH3 ALKBH3 HBE1 HBE1 HBB HBB TH TH UROS UROS CYP26C1 CYP26C1 P4HA1 P4HA1 PHYH PHYH GLUL GLUL CRABP2 CRABP2 S100A8 S100A8 S100A9 S100A9 DBT DBT SCP2 SCP2 FABP3 FABP3 SESN2 SESN2 ID3 ID3 CEP104 CEP104 SRR SRR P2RX1 P2RX1 TM4SF5 TM4SF5 NOS2 NOS2 PIGS PIGS P3H4 P3H4 TYMS TYMS OXER1 OXER1 FABP1 FABP1 THNSL2 THNSL2 CYP27C1 CYP27C1 AGXT AGXT HLCS HLCS GRM7 GRM7 RYR2 RYR2 CK820_G0035770 CK820_G0035770 HBA1 HBA1 KARS1 KARS1 FTCD FTCD SLC46A1 SLC46A1 ENSPTRP00000070073 ENSPTRP00000070073 LOC461877 LOC461877 LOC100609621 LOC100609621 ENSPTRP00000071015 ENSPTRP00000071015 GLRB GLRB NR1H4 NR1H4 ENSPTRP00000073414 ENSPTRP00000073414 OGFOD1 OGFOD1 SERPINA5 SERPINA5 SESN3 SESN3 SHMT1 SHMT1 PPARG PPARG P4HTM P4HTM MCCC1 MCCC1 HBA2 HBA2 ENSPTRP00000090093 ENSPTRP00000090093 ENSPTRP00000084468 ENSPTRP00000084468 P4HA2 P4HA2 LOC473221 LOC473221 P3H2 P3H2 LRAT LRAT TDO2 TDO2 GLRA3 GLRA3 DHFR DHFR GLRA1 GLRA1 RARS1 RARS1 GNMT GNMT AARS2 AARS2 GCLC GCLC SESN1 SESN1 GPR31 GPR31 PLOD3 PLOD3 NOS3 NOS3 FABP5 FABP5 ASS1 ASS1 DBH DBH LCN12 LCN12 OTC OTC GLRA4 GLRA4 CASTOR1 CASTOR1 ENSPTRP00000087913 ENSPTRP00000087913 CPS1 CPS1 CAD CAD SLC19A1 SLC19A1 PLOD2 PLOD2 ENSPTRP00000085408 ENSPTRP00000085408 DDAH1 DDAH1 PLOD1 PLOD1 HBQ1 HBQ1 ENSPTRP00000078641 ENSPTRP00000078641 NR2F2 NR2F2 ACACB ACACB FTCDNL1 FTCDNL1 ENSPTRP00000080096 ENSPTRP00000080096 CYP26B1 CYP26B1 LOC736372 LOC736372 CK820_G0015962 CK820_G0015962 ENSPTRP00000082589 ENSPTRP00000082589 CRTAP CRTAP SLC1A3 SLC1A3 GPR143 GPR143 VDR VDR GRIN3A GRIN3A GRIN1 GRIN1 HBM HBM CASR CASR CYP2W1 CYP2W1 OGFOD3 OGFOD3 EGLN2 EGLN2 MTHFS MTHFS SNCA SNCA DDC DDC GLRA2 GLRA2 NOS1 NOS1 GAD2 GAD2 ENSPTRP00000092218 ENSPTRP00000092218 ENSPTRP00000092229 ENSPTRP00000092229 ENSPTRP00000092611 ENSPTRP00000092611 GRIN2D GRIN2D FOLR2 FOLR2 IGF2R IGF2R ENSPTRP00000063187 ENSPTRP00000063187 SHMT2 SHMT2 EGLN1 EGLN1 ENSPTRP00000062039 ENSPTRP00000062039 PITPNA PITPNA SCLY SCLY UBR2 UBR2 OGFOD2 OGFOD2 P3H1 P3H1 HBG2 HBG2 METTL26 METTL26 DDAH2 DDAH2 HBD HBD AARS1 AARS1 RARA RARA SLC1A1 SLC1A1 GLDC GLDC GRIN3B GRIN3B HBG1 HBG1 PAM PAM PC PC RXRA RXRA CYP26A1 CYP26A1 TAT TAT HBZ HBZ ENSPTRP00000012856 ENSPTRP00000012856 CRABP1 CRABP1 UBR1 UBR1 GCHFR GCHFR EGLN3 EGLN3 PCCA PCCA ALOX5AP ALOX5AP GRIN2B GRIN2B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
YARS2Tyrosine--tRNA ligase. (477 aa)
P3H3Prolyl 3-hydroxylase 3. (736 aa)
P4HA3P4HA3 isoform 4. (544 aa)
FOLR1Folate receptor alpha. (257 aa)
FOLR3Folate receptor 3 (Gamma). (245 aa)
STX3STX3 isoform 2; Belongs to the syntaxin family. (290 aa)
PPARDPeroxisome proliferator-activated receptor delta. (441 aa)
ALKBH3AlkB homolog 3, alpha-ketoglutaratedependent dioxygenase. (286 aa)
HBE1Hemoglobin subunit epsilon; The epsilon chain is a beta-type chain of early mammalian embryonic hemoglobin. (147 aa)
HBBHemoglobin subunit beta; Involved in oxygen transport from the lung to the various peripheral tissues. (147 aa)
THTyrosine hydroxylase. (528 aa)
UROSUroporphyrinogen III synthase. (265 aa)
CYP26C1Cytochrome P450 family 26 subfamily C member 1; Belongs to the cytochrome P450 family. (522 aa)
P4HA1Prolyl 4-hydroxylase, alpha polypeptide I. (552 aa)
PHYHPHYH isoform 2. (353 aa)
GLULGlutamine synthetase. (373 aa)
CRABP2Cellular retinoic acid binding protein 2; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (138 aa)
S100A8Protein S100; Belongs to the S-100 family. (93 aa)
S100A9Protein S100; Belongs to the S-100 family. (114 aa)
DBTDihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (507 aa)
SCP2Sterol carrier protein 2; Belongs to the thiolase-like superfamily. Thiolase family. (547 aa)
FABP3Fatty acid binding protein 3, muscle and heart (Mammary-derived growth inhibitor); Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (133 aa)
SESN2SESN2 isoform 1. (480 aa)
ID3Inhibitor of DNA binding 3, dominant negative helix-loop-helix protein. (119 aa)
CEP104Centrosomal protein 104. (925 aa)
SRRSerine racemase. (340 aa)
P2RX1P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (399 aa)
TM4SF5Transmembrane 4 L six family member 5. (197 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1196 aa)
PIGSPhosphatidylinositol glycan anchor biosynthesis, class S. (555 aa)
P3H4P3H4 isoform 2. (443 aa)
TYMSThymidylate synthetase. (313 aa)
OXER1Oxoeicosanoid receptor 1; Belongs to the G-protein coupled receptor 1 family. (423 aa)
FABP1Fatty acid binding protein 1. (127 aa)
THNSL2Threonine synthase-like 2. (484 aa)
CYP27C1Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family. (372 aa)
AGXTSerine--pyruvate aminotransferase. (367 aa)
HLCSHolocarboxylase synthetase (Biotin-(Proprionyl-Coenzyme A-carboxylase (ATP-hydrolysing)) ligase). (726 aa)
GRM7Glutamate metabotropic receptor 7. (922 aa)
RYR2RYR2 isoform 1. (4941 aa)
CK820_G0035770GLRA2 isoform 4; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (338 aa)
HBA1Hemoglobin subunit alpha; Involved in oxygen transport from the lung to the various peripheral tissues; Belongs to the globin family. (142 aa)
KARS1KARS isoform 4. (629 aa)
FTCDFTCD isoform 4. (53 aa)
SLC46A1Solute carrier family 46 (Folate transporter), member 1. (459 aa)
ENSPTRP00000070073annotation not available (155 aa)
LOC461877Argininosuccinate synthase pseudogene. (389 aa)
LOC100609621Argininosuccinate synthase pseudogene. (245 aa)
ENSPTRP00000071015annotation not available (408 aa)
GLRBGlycine receptor, beta; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (497 aa)
NR1H4Nuclear receptor subfamily 1 group H member 4. (486 aa)
ENSPTRP00000073414annotation not available (393 aa)
OGFOD12-oxoglutarate and iron-dependent oxygenase domain containing 1. (542 aa)
SERPINA5Serpin family A member 5; Belongs to the serpin family. (406 aa)
SESN3SESN3 isoform 5. (492 aa)
SHMT1Serine hydroxymethyltransferase 1. (483 aa)
PPARGPeroxisome proliferator-activated receptor gamma isoform X2. (505 aa)
P4HTMProlyl 4-hydroxylase, transmembrane (Endoplasmic reticulum). (563 aa)
MCCC1Methylcrotonoyl-CoA carboxylase 1 (Alpha). (725 aa)
HBA2Pan troglodytes hemoglobin subunit alpha 2 (HBA2), mRNA. (145 aa)
ENSPTRP00000090093annotation not available (130 aa)
ENSPTRP00000084468annotation not available (154 aa)
P4HA2Prolyl 4-hydroxylase, alpha polypeptide II. (535 aa)
LOC473221Glutamine synthetase pseudogene. (351 aa)
P3H2Leprecan-like 1. (708 aa)
LRATLecithin retinol acyltransferase. (230 aa)
TDO2Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (406 aa)
GLRA3Glycine receptor alpha 3; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (464 aa)
DHFRDihydrofolate reductase; Belongs to the dihydrofolate reductase family. (187 aa)
GLRA1GLRA1 isoform 3; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (451 aa)
RARS1Arginyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (644 aa)
GNMTGlycine N-methyltransferase. (295 aa)
AARS2Alanyl-tRNA synthetase 2, mitochondrial; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. (985 aa)
GCLCGlutamate-cysteine ligase, catalytic subunit. (637 aa)
SESN1SESN1 isoform 1. (551 aa)
GPR31GPR31 isoform 1; Belongs to the G-protein coupled receptor 1 family. (319 aa)
PLOD3Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3. (738 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1203 aa)
FABP5Fatty acid binding protein 5 (Psoriasis-associated); Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (135 aa)
ASS1Argininosuccinate synthetase 1. (412 aa)
DBHDopamine beta-hydroxylase. (617 aa)
LCN12LCN12 isoform 9; Belongs to the calycin superfamily. Lipocalin family. (192 aa)
OTCOrnithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (354 aa)
GLRA4Glycine receptor alpha 4; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (418 aa)
CASTOR1Cytosolic arginine sensor for mTORC1 subunit 1 isoform X2. (351 aa)
ENSPTRP00000087913annotation not available (354 aa)
CPS1Carbamoyl-phosphate synthase 1, mitochondrial. (1507 aa)
CADCarbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. (2229 aa)
SLC19A1Solute carrier family 19 member 1. (590 aa)
PLOD2Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2. (758 aa)
ENSPTRP00000085408annotation not available (162 aa)
DDAH1Dimethylarginine dimethylaminohydrolase 1. (285 aa)
PLOD1Procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1. (737 aa)
HBQ1Hemoglobin subunit theta 1; Belongs to the globin family. (142 aa)
ENSPTRP00000078641annotation not available (167 aa)
NR2F2Nuclear receptor subfamily 2, group F, member 2. (414 aa)
ACACBACACB isoform 2. (2458 aa)
FTCDNL1FTCDNL1 isoform 4. (146 aa)
ENSPTRP00000080096annotation not available (232 aa)
CYP26B1Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa)
LOC736372Glycine dehydrogenase (decarboxylating), mitochondrial pseudogene. (980 aa)
CK820_G0015962ACACB isoform 16. (191 aa)
ENSPTRP00000082589annotation not available (140 aa)
CRTAPCartilage associated protein. (490 aa)
SLC1A3Amino acid transporter. (542 aa)
GPR143G protein-coupled receptor 143. (404 aa)
VDRVitamin D (1,25-dihydroxyvitamin D3) receptor. (477 aa)
GRIN3AGRIN3A isoform 1. (1115 aa)
GRIN1Glutamate receptor, ionotropic, N-methyl D-aspartate 1. (845 aa)
HBMHemoglobin subunit mu; Belongs to the globin family. (141 aa)
CASRCalcium sensing receptor. (1078 aa)
CYP2W1CYP2W1 isoform 1; Belongs to the cytochrome P450 family. (490 aa)
OGFOD3OGFOD3 isoform 4. (331 aa)
EGLN2T0107007 isoform 1. (407 aa)
MTHFS5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (232 aa)
SNCAAlpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] (140 aa)
DDCDopa decarboxylase. (489 aa)
GLRA2Glycine receptor alpha 2; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (452 aa)
NOS1Nitric oxide synthase 1. (1468 aa)
GAD2Glutamate decarboxylase 2. (585 aa)
ENSPTRP00000092218annotation not available (738 aa)
ENSPTRP00000092229annotation not available (407 aa)
ENSPTRP00000092611annotation not available (106 aa)
GRIN2DGRIN2D isoform 1. (1265 aa)
FOLR2Folate receptor beta. (257 aa)
IGF2RIGF2R isoform 2. (2491 aa)
ENSPTRP00000063187annotation not available (125 aa)
SHMT2Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (504 aa)
EGLN1EGLN1 isoform 1. (426 aa)
ENSPTRP00000062039annotation not available (397 aa)
PITPNAPhosphatidylinositol transfer protein, alpha. (276 aa)
SCLYSelenocysteine lyase. (453 aa)
UBR2E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1755 aa)
OGFOD22-oxoglutarate and iron dependent oxygenase domain containing 2. (350 aa)
P3H1P3H1 isoform 6. (797 aa)
HBG2Hemoglobin subunit gamma-2; Gamma chains make up the fetal hemoglobin F, in combination with alpha chains. (147 aa)
METTL26METTL26 isoform 3. (163 aa)
DDAH2Dimethylarginine dimethylaminohydrolase 2. (285 aa)
HBDHemoglobin subunit delta; Belongs to the globin family. (147 aa)
AARS1Alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. (968 aa)
RARARARA isoform 4. (624 aa)
SLC1A1Amino acid transporter. (524 aa)
GLDCGlycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (1020 aa)
GRIN3BGRIN3B isoform 1; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1043 aa)
HBG1Hemoglobin subunit gamma-1; Gamma chains make up the fetal hemoglobin F, in combination with alpha chains. (147 aa)
PAMPeptidylglycine alpha-amidating monooxygenase. (973 aa)
PCPyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1179 aa)
RXRARetinoid X receptor, alpha. (462 aa)
CYP26A1Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family. (497 aa)
TATTyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. (454 aa)
HBZHemoglobin subunit zeta; The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin; Belongs to the globin family. (142 aa)
ENSPTRP00000012856annotation not available (109 aa)
CRABP1Cellular retinoic acid binding protein 1; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (137 aa)
UBR1E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1643 aa)
GCHFRGTP cyclohydrolase I feedback regulator. (84 aa)
EGLN3Egl-9 family hypoxia inducible factor 3. (239 aa)
PCCAPropionyl CoA carboxylase, alpha polypeptide. (728 aa)
ALOX5APArachidonate 5-lipoxygenase activating protein. (218 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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