STRINGSTRING
AURKB AURKB DHRS7B DHRS7B CCL23 CCL23 HDAC5 HDAC5 NOG NOG TEX14 TEX14 TMC8 TMC8 LFNG-2 LFNG-2 GTF2F1 GTF2F1 PIN1 PIN1 PRKACA PRKACA LDLRAP1 LDLRAP1 PCSK9 PCSK9 NES NES SPTA1 SPTA1 MAPRE3 MAPRE3 MITD1 MITD1 ITGA4 ITGA4 PLCL1 PLCL1 TRIB3 TRIB3 BMP2 BMP2 MMP9 MMP9 ADNP ADNP AURKA AURKA CTSZ CTSZ TIAM1 TIAM1 TFIP11 TFIP11 PDGFB PDGFB EP300 EP300 PPARA PPARA CK820_G0054628 CK820_G0054628 EFHB EFHB PRKCD PRKCD CBLB CBLB DTX3L DTX3L PLXND1 PLXND1 ADIPOQ ADIPOQ ADD1 ADD1 LRPAP1 LRPAP1 TERT-2 TERT-2 LOX LOX ENSPTRP00000029492 ENSPTRP00000029492 ADRB2 ADRB2 FLOT1 FLOT1 HSP90AB1 HSP90AB1 BAG2 BAG2 PRKN PRKN KRIT1 KRIT1 CAV1 CAV1 HIPK2 HIPK2 EPHB6 EPHB6 SMARCD3 SMARCD3 CTHRC1 CTHRC1 DERL1 DERL1 LRRC6 LRRC6 CK820_G0008402 CK820_G0008402 SPAG8 SPAG8 ACE ACE MAP2 MAP2 CSF3 CSF3 GOLGA2 GOLGA2 EPB41 EPB41 ADAM15 ADAM15 MAPK8 MAPK8 STYX STYX USP33 USP33 APP APP PLK1 PLK1 BAX BAX ENSPTRP00000092743 ENSPTRP00000092743 ANGPT1 ANGPT1 LOC100614490 LOC100614490 CK820_G0051860 CK820_G0051860 IFIT1 IFIT1 ENSPTRP00000090420 ENSPTRP00000090420 TAF1 TAF1 SNAPIN SNAPIN POLDIP2 POLDIP2 RPL11 RPL11 CAPRIN2 CAPRIN2 NFATC4 NFATC4 PPP2CB PPP2CB HSF1 HSF1 ENSPTRP00000087040 ENSPTRP00000087040 WNT5A WNT5A CAMK1 CAMK1 ID1-2 ID1-2 WFIKKN2 WFIKKN2 MAPK3 MAPK3 APOE APOE SLPI SLPI XIRP1 XIRP1 ACTB ACTB ID1 ID1 CDKN1A CDKN1A CK820_G0012168 CK820_G0012168 EPB41L5 EPB41L5 TERT TERT KDM1A KDM1A ARHGEF7 ARHGEF7 RGMA RGMA STK4 STK4 LOC736031 LOC736031 PPP2CA PPP2CA CARD16 CARD16 KRIT1-2 KRIT1-2 SYMPK SYMPK DNAJB2 DNAJB2 CK820_G0056924 CK820_G0056924 ENSPTRP00000064849 ENSPTRP00000064849 TMBIM6 TMBIM6 PLCL2 PLCL2 RFNG RFNG HOPX HOPX ENSPTRP00000066121 ENSPTRP00000066121 CK820_G0008402-2 CK820_G0008402-2 TGFBR3 TGFBR3 DTNBP1 DTNBP1 CDON CDON USP9X USP9X RIPK2 RIPK2 CRMP1 CRMP1 UBASH3B UBASH3B MAPK10 MAPK10 MARK2 MARK2 ENSPTRP00000070902 ENSPTRP00000070902 TLE5 TLE5 LRP1 LRP1 WFIKKN1 WFIKKN1 LOC104001660 LOC104001660 DAB2 DAB2 ENSPTRP00000071713 ENSPTRP00000071713 MFNG MFNG SNAPIN-2 SNAPIN-2 DDX11 DDX11 ROCK1 ROCK1 ANXA2 ANXA2 AMFR AMFR ENSPTRP00000072741 ENSPTRP00000072741 TDG TDG ABL1 ABL1 HDAC4 HDAC4 TGFBR1 TGFBR1 AURKB-2 AURKB-2 TTBK1 TTBK1 PTPRF PTPRF DVL1 DVL1 RALB RALB ENSPTRP00000074041 ENSPTRP00000074041 AKTIP AKTIP GNL3L GNL3L FRMD7 FRMD7 HIP1R HIP1R SRC SRC CDKN2A CDKN2A SMARCD3-2 SMARCD3-2 CDC42 CDC42 ENSPTRP00000078364 ENSPTRP00000078364 FRMD7-2 FRMD7-2 PARK7 PARK7 CTNNBIP1 CTNNBIP1 DISC1 DISC1 HFE HFE RAPGEF2 RAPGEF2 ADD2 ADD2 NMD3 NMD3 CDK5 CDK5 ENSPTRP00000080351 ENSPTRP00000080351 BMP4-2 BMP4-2 NVL NVL STK3 STK3 GOLGA2-2 GOLGA2-2 ENSPTRP00000081300 ENSPTRP00000081300 MARK3 MARK3 RAN RAN TCF7L2 TCF7L2 GSK3B GSK3B RACK1 RACK1 LOC101058196 LOC101058196 LFNG LFNG AKT1 AKT1 ITGB1BP1 ITGB1BP1 CRK CRK SPON1 SPON1 ATP2A3 ATP2A3 ENSPTRP00000043382 ENSPTRP00000043382 CFHR1 CFHR1 STING1 STING1 BLK BLK GCG GCG TICAM1 TICAM1 IDE IDE WNT3A WNT3A MAPRE1 MAPRE1 PABPN1L PABPN1L FAM192A FAM192A CFHR5 CFHR5 IL10 IL10 BAMBI BAMBI PEX14 PEX14 NRP1 NRP1 DKK1 DKK1 IFIT2 IFIT2 TRIM21 TRIM21 MEN1 MEN1 TTC36 TTC36 SORL1 SORL1 PRMT8 PRMT8 LRRK2 LRRK2 ATP2A2 ATP2A2 PPP1CA PPP1CA SPPL3 SPPL3 ZNF268 ZNF268 TNFSF11 TNFSF11 BMP4 BMP4 DACT1 DACT1 PSEN1 PSEN1 TTBK2 TTBK2 B2M B2M BTBD1 BTBD1 STUB1 STUB1 PRMT7 PRMT7 ZFPM1 ZFPM1 GAS8 GAS8 ARRB2 ARRB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AURKBAURKB isoform 1; Belongs to the protein kinase superfamily. (344 aa)
DHRS7BDHRS7B isoform 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (325 aa)
CCL23C-C motif chemokine. (137 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1115 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
TEX14Testis expressed 14, intercellular bridge forming factor. (1491 aa)
TMC8Transmembrane channel-like protein. (726 aa)
LFNG-2LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase. (242 aa)
GTF2F1Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (517 aa)
PIN1Peptidyl-prolyl cis-trans isomerase. (163 aa)
PRKACAPRKACA isoform 7; Belongs to the protein kinase superfamily. (289 aa)
LDLRAP1Low density lipoprotein receptor adaptor protein 1. (308 aa)
PCSK9Proprotein convertase subtilisin/kexin type 9; Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to [...] (813 aa)
NESNES isoform 1; Belongs to the intermediate filament family. (1620 aa)
SPTA1SPTA1 isoform 1. (2419 aa)
MAPRE3Microtubule-associated protein, RP/EB family, member 3. (281 aa)
MITD1MIT, microtubule interacting and transport, domain containing 1. (249 aa)
ITGA4Integrin, alpha 4 (Antigen CD49D, alpha 4 subunit of VLA-4 receptor); Belongs to the integrin alpha chain family. (1032 aa)
PLCL1Phosphoinositide phospholipase C. (1095 aa)
TRIB3TRIB3 isoform 4. (386 aa)
BMP2Bone morphogenetic protein 2. (398 aa)
MMP9Matrix metallopeptidase 9. (699 aa)
ADNPActivity-dependent neuroprotector homeobox. (1102 aa)
AURKASerine/threonine-protein kinase 6; Belongs to the protein kinase superfamily. (403 aa)
CTSZCTSZ isoform 1; Belongs to the peptidase C1 family. (303 aa)
TIAM1T-cell lymphoma invasion and metastasis 1. (1591 aa)
TFIP11Tuftelin-interacting protein 11; Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP- containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extrac [...] (837 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
EP300E1A binding protein p300. (2175 aa)
PPARAPeroxisome proliferator-activated receptor alpha. (467 aa)
CK820_G0054628PKD1 isoform 4. (3384 aa)
EFHBEF-hand domain family member B. (833 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
CBLBCas-Br-M (Murine) ecotropic retroviral transforming sequence b. (982 aa)
DTX3LDeltex E3 ubiquitin ligase 3L. (740 aa)
PLXND1PLXND1 isoform 1. (1925 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
ADD1ADD1 isoform 5. (768 aa)
LRPAP1Low density lipoprotein receptor-related protein associated protein 1. (357 aa)
TERT-2Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (762 aa)
LOXLOX isoform 1. (417 aa)
ENSPTRP00000029492annotation not available (223 aa)
ADRB2Adrenergic, beta-2-, receptor, surface. (429 aa)
FLOT1Flotillin-1; May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. (427 aa)
HSP90AB1HSP90AB1 isoform 1. (688 aa)
BAG2BCL2-associated athanogene 2. (211 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (465 aa)
KRIT1KRIT1, ankyrin repeat containing. (736 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
HIPK2Homeodomain interacting protein kinase 2. (1198 aa)
EPHB6Ephrin type-B receptor 6; Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2 (By similarity). (1020 aa)
SMARCD3SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (483 aa)
CTHRC1Collagen triple helix repeat containing 1. (243 aa)
DERL1Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (251 aa)
LRRC6LRRC6 isoform 1. (466 aa)
CK820_G0008402Annexin. (233 aa)
SPAG8SPAG8 isoform 1. (497 aa)
ACEAngiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family. (1306 aa)
MAP2Microtubule-associated protein. (1827 aa)
CSF3Colony stimulating factor 3 (Granulocyte). (204 aa)
GOLGA2GOLGA2 isoform 6. (1005 aa)
EPB41Erythrocyte membrane protein band 4.1. (864 aa)
ADAM15ADAM metallopeptidase domain 15. (863 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
STYXSerine/threonine/tyrosine interacting protein. (223 aa)
USP33Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (942 aa)
APPGamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (771 aa)
PLK1Serine/threonine-protein kinase PLK. (621 aa)
BAXBAX isoform 7. (123 aa)
ENSPTRP00000092743annotation not available (379 aa)
ANGPT1ANGPT1 isoform 2. (498 aa)
LOC100614490G/T mismatch-specific thymine DNA glycosylase pseudogene. (405 aa)
CK820_G0051860DDX11 isoform 28. (265 aa)
IFIT1Interferon-induced protein with tetratricopeptide repeats 1. (478 aa)
ENSPTRP00000090420annotation not available (273 aa)
TAF1Transcription initiation factor TFIID subunit. (1927 aa)
SNAPINSNAP associated protein. (137 aa)
POLDIP2DNA polymerase delta interacting protein 2. (368 aa)
RPL11Ribosomal protein L11; Belongs to the universal ribosomal protein uL5 family. (178 aa)
CAPRIN2Caprin family member 2. (1077 aa)
NFATC4Nuclear factor of activated T cells 4. (933 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
HSF1Heat shock transcription factor 1. (529 aa)
ENSPTRP00000087040annotation not available (499 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
CAMK1Calcium/calmodulin-dependent protein kinase I; Belongs to the protein kinase superfamily. (380 aa)
ID1-2Inhibitor of DNA binding 1, HLH protein. (155 aa)
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2. (576 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
APOEApolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (317 aa)
SLPISecretory leukocyte peptidase inhibitor. (132 aa)
XIRP1Xin actin binding repeat containing 1. (1121 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (378 aa)
ID1Inhibitor of DNA binding 1, dominant negative helix-loop-helix protein. (155 aa)
CDKN1ACyclin-dependent kinase inhibitor 1A (P21, Cip1). (276 aa)
CK820_G0012168ABL1 isoform 3. (1149 aa)
EPB41L5Erythrocyte membrane protein band 4.1 like 5. (733 aa)
TERTTelomerase reverse transcriptase. (360 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (876 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7. (862 aa)
RGMARepulsive guidance molecule BMP co-receptor a. (458 aa)
STK4Serine/threonine-protein kinase 4. (487 aa)
LOC736031AKT-interacting protein pseudogene. (286 aa)
PPP2CAPPP2CB isoform 8. (309 aa)
CARD16Caspase recruitment domain-containing protein 16 isoform X4. (197 aa)
KRIT1-2KRIT1 ankyrin repeat containing. (736 aa)
SYMPKSYMPK isoform 3. (1310 aa)
DNAJB2DnaJ heat shock protein family (Hsp40) member B2. (324 aa)
CK820_G0056924NPIPA2 isoform 1. (277 aa)
ENSPTRP00000064849annotation not available (150 aa)
TMBIM6Transmembrane BAX inhibitor motif containing 6; Belongs to the BI1 family. (291 aa)
PLCL2Phosphoinositide phospholipase C. (1127 aa)
RFNGBeta-1,3-N-acetylglucosaminyltransferase. (333 aa)
HOPXHOPX isoform 3. (112 aa)
ENSPTRP00000066121annotation not available (305 aa)
CK820_G0008402-2Annexin. (325 aa)
TGFBR3Transforming growth factor, beta receptor III. (861 aa)
DTNBP1Dystrobrevin binding protein 1. (351 aa)
CDONCell adhesion associated, oncogene regulated. (1286 aa)
USP9XUbiquitin specific peptidase 9, X-linked; Belongs to the peptidase C19 family. (2591 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (551 aa)
CRMP1Collapsin response mediator protein 1. (686 aa)
UBASH3BUbiquitin associated and SH3 domain containing B. (649 aa)
MAPK10Mitogen-activated protein kinase. (551 aa)
MARK2Non-specific serine/threonine protein kinase. (668 aa)
ENSPTRP00000070902annotation not available (168 aa)
TLE5AES isoform 1. (203 aa)
LRP1LDL receptor related protein 1. (4544 aa)
WFIKKN1WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1. (548 aa)
LOC104001660Putative golgin subfamily A member 2B. (141 aa)
DAB2Disabled homolog 2, mitogen-responsive phosphoprotein. (770 aa)
ENSPTRP00000071713annotation not available (185 aa)
MFNGBeta-1,3-N-acetylglucosaminyltransferase manic fringe; Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O- fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1. (321 aa)
SNAPIN-2SNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (137 aa)
DDX11DDX11 isoform 5. (933 aa)
ROCK1Rho-associated protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (By simi [...] (1368 aa)
ANXA2Annexin. (357 aa)
AMFRAutocrine motility factor receptor. (643 aa)
ENSPTRP00000072741annotation not available (133 aa)
TDGThymine-DNA glycosylase. (410 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1089 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
AURKB-2Aurora kinase B. (344 aa)
TTBK1Tau tubulin kinase 1. (1321 aa)
PTPRFProtein tyrosine phosphatase, receptor type, F. (1914 aa)
DVL1Segment polarity protein dishevelled homolog DVL-1; Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) (By simi [...] (743 aa)
RALBV-ral simian leukemia viral oncogene homolog B (Ras related GTP binding protein). (212 aa)
ENSPTRP00000074041annotation not available (223 aa)
AKTIPAKT interacting protein. (293 aa)
GNL3LGuanine nucleotide binding protein-like 3 (Nucleolar)-like. (585 aa)
FRMD7FERM domain containing 7. (594 aa)
HIP1RHuntingtin interacting protein 1 related. (1068 aa)
SRCTyrosine-protein kinase. (542 aa)
CDKN2ACyclin-dependent kinase inhibitor 2A (Melanoma, p16, inhibits CDK4). (173 aa)
SMARCD3-2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (483 aa)
CDC42Cell division cycle 42 (GTP binding protein, 25kDa). (191 aa)
ENSPTRP00000078364annotation not available (111 aa)
FRMD7-2FERM domain containing 7. (714 aa)
PARK7PARK7 isoform 1. (189 aa)
CTNNBIP1Catenin, beta interacting protein 1. (81 aa)
DISC1Disrupted in schizophrenia 1 protein isoform X1. (977 aa)
HFEHereditary hemochromatosis protein homolog; Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin. (348 aa)
RAPGEF2RAPGEF2 isoform 2. (1701 aa)
ADD2ADD2 isoform 1. (726 aa)
NMD360S ribosomal export protein NMD3; Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit; Belongs to the NMD3 family. (529 aa)
CDK5Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily. (311 aa)
ENSPTRP00000080351annotation not available (266 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
NVLNuclear VCP-like. (856 aa)
STK3Serine/threonine kinase 3. (519 aa)
GOLGA2-2GOLGA2 isoform 4. (1034 aa)
ENSPTRP00000081300annotation not available (154 aa)
MARK3Non-specific serine/threonine protein kinase. (776 aa)
RANGTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family. (234 aa)
TCF7L2Transcription factor 7 like 2. (619 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (481 aa)
RACK1Receptor for activated C kinase 1. (321 aa)
LOC101058196Golgin subfamily A member 6-like protein 9. (185 aa)
LFNGLFNG isoform 5. (405 aa)
AKT1AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (200 aa)
CRKV-crk sarcoma virus CT10 oncogene homolog (Avian). (304 aa)
SPON1Spondin 1, extracellular matrix protein. (807 aa)
ATP2A3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1052 aa)
ENSPTRP00000043382annotation not available (185 aa)
CFHR1T0196413 isoform 1. (282 aa)
STING1TMEM173 isoform 2. (379 aa)
BLKTyrosine-protein kinase. (505 aa)
GCGGCG isoform 1. (180 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (543 aa)
IDEInsulin-degrading enzyme; Belongs to the peptidase M16 family. (1019 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
MAPRE1MAPRE1 isoform 1. (268 aa)
PABPN1LPoly(A) binding protein nuclear 1 like, cytoplasmic. (278 aa)
FAM192AFAM192A isoform 17. (254 aa)
CFHR5CFHR5 isoform 1. (569 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
PEX14Peroxisomal biogenesis factor 14. (377 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
DKK1Dickkopf-like protein 1. (289 aa)
IFIT2Interferon-induced protein with tetratricopeptide repeats 2. (472 aa)
TRIM21Tripartite motif containing 21. (475 aa)
MEN1MEN1 isoform 14. (615 aa)
TTC36TTC36 isoform 3. (206 aa)
SORL1Sortilin related receptor 1. (2214 aa)
PRMT8Protein arginine methyltransferase 8; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (394 aa)
LRRK2Leucine-rich repeat kinase 2. (2527 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1042 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (455 aa)
SPPL3Signal peptide peptidase-like protein 3. (384 aa)
ZNF268Zinc finger protein 268. (949 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (317 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
DACT1Dishevelled binding antagonist of beta catenin 1. (836 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
TTBK2TTBK2 isoform 2; Belongs to the intermediate filament family. (1649 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). (96 aa)
BTBD1BTB (POZ) domain containing 1. (484 aa)
STUB1STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase. (303 aa)
PRMT7Protein arginine N-methyltransferase; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being r [...] (692 aa)
ZFPM1ZFPM1 isoform 1. (974 aa)
GAS8Growth arrest-specific 8. (537 aa)
ARRB2ARRB2 isoform 2. (430 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: low (16%) [HD]