STRINGSTRING
CTNNB1 CTNNB1 POU4F1 POU4F1 PCSK9 PCSK9 MCL1 MCL1 FASLG FASLG TGFB2 TGFB2 PITX3 PITX3 MAP3K11 MAP3K11 IL18 IL18 BACE1 BACE1 PAWR PAWR NUPR1 NUPR1 ITGAM ITGAM NQO1 NQO1 TP53 TP53 MAP2K4 MAP2K4 NF1 NF1 GRN GRN CDC34 CDC34 GRIK5 GRIK5 GSK3A GSK3A MYBL2 MYBL2 ATF4 ATF4 RHOA RHOA CDV3 CDV3 FBXW7 FBXW7 ITGA1 ITGA1 NR3C1 NR3C1 EPHA7 EPHA7 CASP2 CASP2 RAPSN RAPSN DDIT3 DDIT3 BAX BAX ENSPTRP00000090476 ENSPTRP00000090476 CK820_G0030015 CK820_G0030015 CASP9 CASP9 NFATC4 NFATC4 SRPK2 SRPK2 TFAP2A TFAP2A ENSPTRP00000087425 ENSPTRP00000087425 ENSPTRP00000086525 ENSPTRP00000086525 BBC3-2 BBC3-2 ENSPTRP00000082515 ENSPTRP00000082515 CDK5 CDK5 LOC745935 LOC745935 ASCL1 ASCL1 TFAP2B TFAP2B BCL2L11 BCL2L11 BBC3 BBC3 ENSPTRP00000076061 ENSPTRP00000076061 PRNP PRNP MAP2K7 MAP2K7 ABL1 ABL1 CASP2-2 CASP2-2 ENSPTRP00000071419 ENSPTRP00000071419 AIFM1 AIFM1 TNF TNF LOC100611078 LOC100611078 ATF2 ATF2 FBXW9 FBXW9 CK820_G0012168 CK820_G0012168 CCL3 CCL3 ATM ATM CDK5R1 CDK5R1 UBE2M UBE2M
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
POU4F1POU domain protein. (350 aa)
PCSK9Proprotein convertase subtilisin/kexin type 9; Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to [...] (813 aa)
MCL1Myeloid cell leukemia sequence 1 (BCL2-related). (350 aa)
FASLGFASLG isoform 1; Belongs to the tumor necrosis factor family. (280 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
PITX3Homeobox protein. (302 aa)
MAP3K11Mitogen-activated protein kinase kinase kinase 11 isoform X2. (847 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
BACE1Beta-site APP-cleaving enzyme 1; Belongs to the peptidase A1 family. (501 aa)
PAWRPRKC, apoptosis, WT1, regulator. (340 aa)
NUPR1Nuclear protein 1, transcriptional regulator. (82 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1152 aa)
NQO1NAD(P)H quinone dehydrogenase 1. (274 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (410 aa)
NF1Neurofibromin 1. (2839 aa)
GRNGranulin precursor. (593 aa)
CDC34Cell division cycle 34 homolog; Belongs to the ubiquitin-conjugating enzyme family. (235 aa)
GRIK5GRIK5 isoform 1. (980 aa)
GSK3AGlycogen synthase kinase 3 alpha. (483 aa)
MYBL2V-myb myeloblastosis viral oncogene homolog (Avian)-like 2. (699 aa)
ATF4Activating transcription factor 4 (Tax-responsive enhancer element B67). (351 aa)
RHOARas homolog family member A. (193 aa)
CDV3CDV3 isoform 2. (211 aa)
FBXW7F-box and WD repeat domain containing 7. (707 aa)
ITGA1Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1179 aa)
NR3C1NR3C1 isoform 5. (778 aa)
EPHA7EPHA7 isoform 2. (998 aa)
CASP2Caspase 2, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (452 aa)
RAPSNReceptor-associated protein of the synapse. (412 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (192 aa)
BAXBAX isoform 7. (123 aa)
ENSPTRP00000090476annotation not available (201 aa)
CK820_G0030015CDV3 isoform 4. (167 aa)
CASP9CASP9 isoform 4; Belongs to the peptidase C14A family. (421 aa)
NFATC4Nuclear factor of activated T cells 4. (933 aa)
SRPK2SRSF protein kinase 2. (698 aa)
TFAP2ATranscription factor AP-2 alpha. (439 aa)
ENSPTRP00000087425annotation not available (336 aa)
ENSPTRP00000086525annotation not available (336 aa)
BBC3-2BCL2 binding component 3. (270 aa)
ENSPTRP00000082515annotation not available (336 aa)
CDK5Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily. (311 aa)
LOC745935C-C motif chemokine. (87 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (232 aa)
TFAP2BTranscription factor AP-2 beta. (467 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
BBC3BCL2 binding component 3. (270 aa)
ENSPTRP00000076061annotation not available (148 aa)
PRNPMajor prion protein; Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan s [...] (253 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (438 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
CASP2-2Caspase 2. (452 aa)
ENSPTRP00000071419annotation not available (371 aa)
AIFM1Apoptosis-inducing factor, mitochondrion-associated, 1. (603 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
LOC100611078Cyclic AMP-dependent transcription factor ATF-4 pseudogene. (318 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
FBXW9F-box and WD repeat domain containing 9. (478 aa)
CK820_G0012168ABL1 isoform 3. (1149 aa)
CCL3C-C motif chemokine 3; Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5 (By similarity); Belongs to the intercrine beta (chemokine CC) family. (92 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
CDK5R1Cyclin-dependent kinase 5 activator. (307 aa)
UBE2MUbiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family. (183 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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