20 items (Pan troglodytes) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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Predicted Interactions

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Your Input:
	HOXC13	HOXC13 isoform 1. (330 aa)
	NTF4	NTF4 isoform 1; Belongs to the NGF-beta family. (210 aa)
	WNT10A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
	TBX1	TBX1 isoform 1. (478 aa)
	KIT	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
	WNT10B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
	INTU	Inturned planar cell polarity effector homolog. (911 aa)
	CYP26B1	Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa)
	LEF1	Lymphoid enhancer binding factor 1. (414 aa)
	HDAC1	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
	LOC748850	HDAC2 isoform 9. (445 aa)
	KCNE2	KCNE2 isoform 1. (123 aa)
	HAND2	Heart and neural crest derivatives expressed 2. (217 aa)
	HDAC2	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (581 aa)
	BNC2	BNC2 isoform 3. (1099 aa)
	CTNNB1	Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
	WDPCP	WDPCP isoform 2. (746 aa)
	SIX4	SIX homeobox 4. (781 aa)
	NKX2-6	NKX2-6 isoform 1. (301 aa)
	GLI3	Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CTNNB1	GLI3	ENSPTRP00000044466	ENSPTRP00000032656	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...]	0.520
CTNNB1	HDAC1	ENSPTRP00000044466	ENSPTRP00000075891	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.912
CTNNB1	HDAC2	ENSPTRP00000044466	ENSPTRP00000049696	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	0.689
CTNNB1	KIT	ENSPTRP00000044466	ENSPTRP00000027637	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.563
CTNNB1	LEF1	ENSPTRP00000044466	ENSPTRP00000079959	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Lymphoid enhancer binding factor 1.	0.999
CTNNB1	LOC748850	ENSPTRP00000044466	ENSPTRP00000067224	Catenin (Cadherin-associated protein), beta 1, 88kDa.	HDAC2 isoform 9.	0.912
CTNNB1	WNT10A	ENSPTRP00000044466	ENSPTRP00000022097	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.583
CTNNB1	WNT10B	ENSPTRP00000044466	ENSPTRP00000008363	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.634
GLI3	CTNNB1	ENSPTRP00000032656	ENSPTRP00000044466	Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...]	Catenin (Cadherin-associated protein), beta 1, 88kDa.	0.520
GLI3	HAND2	ENSPTRP00000032656	ENSPTRP00000050916	Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...]	Heart and neural crest derivatives expressed 2.	0.480
GLI3	INTU	ENSPTRP00000032656	ENSPTRP00000028215	Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...]	Inturned planar cell polarity effector homolog.	0.424
HAND2	GLI3	ENSPTRP00000050916	ENSPTRP00000032656	Heart and neural crest derivatives expressed 2.	Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...]	0.480
HDAC1	CTNNB1	ENSPTRP00000075891	ENSPTRP00000044466	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	Catenin (Cadherin-associated protein), beta 1, 88kDa.	0.912
HDAC1	HDAC2	ENSPTRP00000075891	ENSPTRP00000049696	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	0.999
HDAC1	LEF1	ENSPTRP00000075891	ENSPTRP00000079959	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	Lymphoid enhancer binding factor 1.	0.763
HDAC2	CTNNB1	ENSPTRP00000049696	ENSPTRP00000044466	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Catenin (Cadherin-associated protein), beta 1, 88kDa.	0.689
HDAC2	HDAC1	ENSPTRP00000049696	ENSPTRP00000075891	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.999
HDAC2	LEF1	ENSPTRP00000049696	ENSPTRP00000079959	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Lymphoid enhancer binding factor 1.	0.564
HDAC2	LOC748850	ENSPTRP00000049696	ENSPTRP00000067224	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	HDAC2 isoform 9.	0.994
HOXC13	LEF1	ENSPTRP00000008554	ENSPTRP00000079959	HOXC13 isoform 1.	Lymphoid enhancer binding factor 1.	0.405