STRINGSTRING
KRT28 KRT28 TSG101 TSG101 WDR48 WDR48 LOC104003639 LOC104003639 STK4 STK4 ENSPTRP00000063255 ENSPTRP00000063255 LOC738608 LOC738608 ASAH1 ASAH1 ATP7A ATP7A TNFRSF19 TNFRSF19 CK820_G0056924 CK820_G0056924 SPRR2B SPRR2B NSDHL-2 NSDHL-2 UGCG UGCG PAX6 PAX6 SNAI1 SNAI1 LOC452254 LOC452254 ENSPTRP00000067051 ENSPTRP00000067051 LOC748850 LOC748850 LOC457411 LOC457411 SMO-2 SMO-2 PPP3CA PPP3CA SOSTDC1 SOSTDC1 ABCB6 ABCB6 EXPH5 EXPH5 S100A7A S100A7A KRT83 KRT83 ENSPTRP00000069368 ENSPTRP00000069368 EGFR EGFR PTCH2 PTCH2 LCE3E LCE3E KRT75 KRT75 ENSPTRP00000073578 ENSPTRP00000073578 PIP5K1A PIP5K1A SUFU SUFU ITGB6 ITGB6 COL5A1 COL5A1 CLDN4-2 CLDN4-2 ENSPTRP00000075125 ENSPTRP00000075125 CD109 CD109 PPHLN1 PPHLN1 TRPC4AP TRPC4AP ENSPTRP00000075643 ENSPTRP00000075643 SHH SHH HRNR HRNR HDAC1 HDAC1 S100A7 S100A7 KRT80 KRT80 ENSPTRP00000076491 ENSPTRP00000076491 EZH2 EZH2 CDSN CDSN TFAP2B TFAP2B LOC738560 LOC738560 AKR1C3 AKR1C3 TCHH TCHH ERCC2 ERCC2 RBPJ RBPJ MADCAM1 MADCAM1 LGR5 LGR5 ZMPSTE24 ZMPSTE24 ELOVL1 ELOVL1 CYP26B1 CYP26B1 LDB2 LDB2 ENSPTRP00000081042 ENSPTRP00000081042 LOC104001457 LOC104001457 LSR LSR LRP4 LRP4 ITGB4 ITGB4 ITGA2 ITGA2 ENSPTRP00000082912 ENSPTRP00000082912 GRHL3 GRHL3 ENSPTRP00000083068 ENSPTRP00000083068 MET MET ALX4 ALX4 FGF10 FGF10 CK820_G0054628 CK820_G0054628 SLC27A4 SLC27A4 PALLD PALLD FOSL2 FOSL2 WNT5A WNT5A ENSPTRP00000087057 ENSPTRP00000087057 ITGA6 ITGA6 PIPSL PIPSL ENSPTRP00000088411 ENSPTRP00000088411 SPRR2G SPRR2G SOSTDC1-2 SOSTDC1-2 FLNB FLNB KRT8 KRT8 LAMA5 LAMA5 ENSPTRP00000089841 ENSPTRP00000089841 BCL2 BCL2 EZH2-2 EZH2-2 ST14 ST14 CK820_G0030361 CK820_G0030361 LOC739070 LOC739070 KRT7 KRT7 PLA2G10 PLA2G10 IRF6 IRF6 RYR1 RYR1 PTGES3 PTGES3 ADAM9 ADAM9 KRT3 KRT3 LCE3D LCE3D LGR4 LGR4 SCEL SCEL INHBA INHBA GRHL1 GRHL1 CLDN4 CLDN4 KRT74 KRT74 CASP14 CASP14 LCE6A LCE6A LOC451917 LOC451917 GNAS GNAS SHARPIN SHARPIN CERS3 CERS3 PNPLA1 PNPLA1 COMP COMP KAZN KAZN SFN SFN KRT2 KRT2 RELA RELA CASP3 CASP3 CK820_G0018145 CK820_G0018145 KRTAP6-2 KRTAP6-2 POU3F1 POU3F1 BCL11B BCL11B MAFB MAFB SOS1 SOS1 RPTN RPTN FLG FLG IVL IVL FOXQ1 FOXQ1 LIPK LIPK LIPN LIPN LTB LTB KRT81 KRT81 HDAC2 HDAC2 APCDD1 APCDD1 ANXA1 ANXA1 COL5A2 COL5A2 FRAS1 FRAS1 ATP8A2 ATP8A2 FOXE1 FOXE1 NSUN2 NSUN2 CTNNB1 CTNNB1 FZD6 FZD6 KRT1 KRT1 S100A7L2 S100A7L2 DSG4 DSG4 KRT78 KRT78 GLI2 GLI2 LDB1 LDB1 BCR BCR NSDHL NSDHL EDA EDA NOTCH1 NOTCH1 LHX2 LHX2 KLF4 KLF4 ENSPTRP00000036205 ENSPTRP00000036205 IFT74 IFT74 ZDHHC21 ZDHHC21 PLEC PLEC TBC1D31 TBC1D31 EXT1 EXT1 FZD3 FZD3 NOM1 NOM1 SMO SMO WNT16 WNT16 COL1A2 COL1A2 DLL1 DLL1 DACT2 DACT2 LATS1 LATS1 TRAF3IP2 TRAF3IP2 SRF SRF DSP DSP ADAMTS2 ADAMTS2 ARRDC3 ARRDC3 AP3B1 AP3B1 FST FST INTU INTU EREG EREG CLDN1 CLDN1 TP63 TP63 CSTA CSTA KRTAP21-1 KRTAP21-1 KRTAP6-1 KRTAP6-1 SOX18 SOX18 SLC2A10 SLC2A10 JAG1 JAG1 WNT10A WNT10A IGFBP5 IGFBP5 ABCA12 ABCA12 COL3A1 COL3A1 IL1A IL1A EDAR EDAR STARD7 STARD7 ASPRV1 ASPRV1 PUM2 PUM2 KLK5 KLK5 FUZ FUZ CNFN CNFN COL5A3 COL5A3 ACER1 ACER1 PIAS4 PIAS4 SMAD4 SMAD4 GATA6 GATA6 EVPL EVPL SOX9 SOX9 COL1A1 COL1A1 ITGA3 ITGA3 DLX3 DLX3 NGFR NGFR JUP JUP KRT17 KRT17 KRT9 KRT9 KRT10 KRT10 KRT27 KRT27 KRT25 KRT25 MED1 MED1 NF1 NF1 FOXN1 FOXN1 KRT16 KRT16 LOC454470 LOC454470 ALOX12B ALOX12B ALOX12 ALOX12 FA2H FA2H CDH3 CDH3 PPL PPL DNASE1L2 DNASE1L2 FGF7 FGF7 PSEN1 PSEN1 SAV1 SAV1 TGM1 TGM1 SLITRK5 SLITRK5 LATS2 LATS2 ASCL4 ASCL4 HOXC13 HOXC13 KRT79 KRT79 KRT4 KRT4 KRT76 KRT76 KRT77 KRT77 KRT73 KRT73 KRT72 KRT72 KRT71 KRT71 KRT5 KRT5 KRT82 KRT82 KRT84 KRT84 KRT85 KRT85 CK820_G0039600 CK820_G0039600 ACVR1B ACVR1B IL18 IL18 YAP1 YAP1 OVOL1 OVOL1 FGFR2 FGFR2 LIPM LIPM DKK1 DKK1 OPN3 OPN3 TGFB2 TGFB2 GORAB GORAB TMEM79 TMEM79 ASH1L ASH1L SPRR3 SPRR3 LCE1A LCE1A LCE3A LCE3A LCE3B LCE3B LCE3C LCE3C LCE5A LCE5A TXNIP TXNIP DHCR24 DHCR24 KDF1 KDF1 STMN1 STMN1 CLIC4 CLIC4 EPHA2 EPHA2 ERRFI1 ERRFI1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KRT28KRT28 isoform 1; Belongs to the intermediate filament family. (464 aa)
TSG101Tumor susceptibility 101. (405 aa)
WDR48WD repeat domain 48. (684 aa)
LOC104003639Guanine nucleotide-binding protein G(s) subunit alpha. (245 aa)
STK4Serine/threonine-protein kinase 4. (487 aa)
ENSPTRP00000063255annotation not available (394 aa)
LOC738608KRT6B isoform 1; Belongs to the intermediate filament family. (564 aa)
ASAH1Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...] (411 aa)
ATP7AATPase, Cu++ transporting, alpha polypeptide. (1500 aa)
TNFRSF19Tumor necrosis factor receptor superfamily, member 19. (417 aa)
CK820_G0056924NPIPA2 isoform 1. (277 aa)
SPRR2BSmall proline-rich protein 2A. (72 aa)
NSDHL-2NAD(P) dependent steroid dehydrogenase-like. (373 aa)
UGCGUDP-glucose ceramide glucosyltransferase. (394 aa)
PAX6PAX6 isoform 13. (436 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
LOC452254LOW QUALITY PROTEIN: disintegrin and metalloproteinase domain-containing protein 1-like. (863 aa)
ENSPTRP00000067051annotation not available (137 aa)
LOC748850HDAC2 isoform 9. (445 aa)
LOC457411Keratin, type II cytoskeletal 8 pseudogene. (503 aa)
SMO-2Smoothened, frizzled class receptor. (786 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
SOSTDC1Sclerostin domain containing 1. (230 aa)
ABCB6ATP-binding cassette, sub-family B (MDR/TAP), member 6. (854 aa)
EXPH5EXPH5 isoform 2. (1988 aa)
S100A7AProtein S100; Belongs to the S-100 family. (101 aa)
KRT83Keratin, type II cuticular Hb3. (501 aa)
ENSPTRP00000069368annotation not available (459 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
PTCH2PTCH2 isoform 3. (1203 aa)
LCE3ELate cornified envelope 3E. (92 aa)
KRT75KRT75 isoform 1; Belongs to the intermediate filament family. (551 aa)
ENSPTRP00000073578annotation not available (588 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (562 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (519 aa)
ITGB6ITGB6 isoform 3. (701 aa)
COL5A1Collagen type V alpha 1 chain. (1841 aa)
CLDN4-2Claudin 4. (209 aa)
ENSPTRP00000075125annotation not available (537 aa)
CD109CD109 isoform 3. (1446 aa)
PPHLN1PPHLN1 isoform 4. (458 aa)
TRPC4APTransient receptor potential cation channel, subfamily C, member 4 associated protein. (797 aa)
ENSPTRP00000075643Prostaglandin E synthase 3-like isoform X1. (165 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
HRNRHRNR isoform 1. (2233 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
S100A7Protein S100; Belongs to the S-100 family. (101 aa)
KRT80KRT80 isoform 1; Belongs to the intermediate filament family. (497 aa)
ENSPTRP00000076491annotation not available (91 aa)
EZH2Enhancer of zeste homolog 2. (754 aa)
CDSNCorneodesmosin; Important for the epidermal barrier integrity. (536 aa)
TFAP2BTranscription factor AP-2 beta. (467 aa)
LOC738560Keratin, type II cytoskeletal 6B. (472 aa)
AKR1C3Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II). (323 aa)
TCHHTCHH isoform 1. (1384 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (760 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (500 aa)
MADCAM1MADCAM1 isoform 9. (414 aa)
LGR5Leucine rich repeat containing G protein-coupled receptor 5. (907 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (480 aa)
ELOVL1Elongation of very long chain fatty acids protein 1; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that [...] (291 aa)
CYP26B1Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa)
LDB2LIM domain binding 2. (373 aa)
ENSPTRP00000081042annotation not available (262 aa)
LOC104001457Prostaglandin E synthase 3-like isoform X1. (160 aa)
LSRLipolysis stimulated lipoprotein receptor. (650 aa)
LRP4Low density lipoprotein receptor-related protein 4. (1906 aa)
ITGB4Integrin beta. (1822 aa)
ITGA2Integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); Belongs to the integrin alpha chain family. (1183 aa)
ENSPTRP00000082912annotation not available (153 aa)
GRHL3Grainyhead like transcription factor 3. (626 aa)
ENSPTRP00000083068annotation not available (421 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1413 aa)
ALX4ALX homeobox 4. (411 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
CK820_G0054628PKD1 isoform 4. (3384 aa)
SLC27A4Solute carrier family 27 (Fatty acid transporter), member 4. (646 aa)
PALLDPalladin, cytoskeletal associated protein. (1123 aa)
FOSL2FOS like 2, AP-1 transcription factor subunit. (326 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
ENSPTRP00000087057annotation not available (440 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1130 aa)
PIPSLPIP5K1A and PSMD4-like. (548 aa)
ENSPTRP00000088411annotation not available (465 aa)
SPRR2GSmall proline rich protein 2G. (73 aa)
SOSTDC1-2Sclerostin domain containing 1. (206 aa)
FLNBFilamin B, beta. (2633 aa)
KRT8KRT8 isoform 11; Belongs to the intermediate filament family. (483 aa)
LAMA5Laminin, alpha 5. (2203 aa)
ENSPTRP00000089841annotation not available (259 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
EZH2-2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (751 aa)
ST14Suppressor of tumorigenicity 14 protein homolog; Degrades extracellular matrix. Belongs to the peptidase S1 family. (862 aa)
CK820_G0030361RYR1 isoform 5. (4901 aa)
LOC739070PLA2G10 isoform 1. (165 aa)
KRT7Keratin, type II cytoskeletal 7; Blocks interferon-dependent interphase and stimulates DNA synthesis in cells; Belongs to the intermediate filament family. (469 aa)
PLA2G10Group 10 secretory phospholipase A2-like. (165 aa)
IRF6Interferon regulatory factor 6. (467 aa)
RYR1RYR1 isoform 3. (5037 aa)
PTGES3Prostaglandin E synthase 3. (164 aa)
ADAM9ADAM metallopeptidase domain 9. (819 aa)
KRT3KRT3 isoform 1; Belongs to the intermediate filament family. (629 aa)
LCE3DLate cornified envelope 3D. (92 aa)
LGR4LGR4 isoform 2. (951 aa)
SCELSCEL isoform 3. (688 aa)
INHBAInhibin subunit beta A. (426 aa)
GRHL1Grainyhead like transcription factor 1. (619 aa)
CLDN4Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (209 aa)
KRT74KRT74 isoform 2; Belongs to the intermediate filament family. (543 aa)
CASP14CASP14 isoform 1; Belongs to the peptidase C14A family. (242 aa)
LCE6ALate cornified envelope 6A. (80 aa)
LOC451917Keratin, type II cuticular Hb1-like. (462 aa)
GNASGNAS isoform 19. (1042 aa)
SHARPINSHANK-associated RH domain interactor. (387 aa)
CERS3CERS3 isoform 1. (383 aa)
PNPLA1Patatin like phospholipase domain containing 1. (533 aa)
COMPCartilage oligomeric matrix protein. (757 aa)
KAZNKazrin, periplakin interacting protein. (863 aa)
SFNSFN isoform 1; Belongs to the 14-3-3 family. (248 aa)
KRT2KRT2 isoform 1; Belongs to the intermediate filament family. (645 aa)
RELAV-rel reticuloendotheliosis viral oncogene homolog A (Avian). (551 aa)
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. (277 aa)
CK820_G0018145KRTAP6-3 isoform 1. (93 aa)
KRTAP6-2Keratin associated protein 6-2. (62 aa)
POU3F1POU domain protein. (451 aa)
BCL11BBAF chromatin remodeling complex subunit BCL11B. (894 aa)
MAFBV-maf musculoaponeurotic fibrosarcoma oncogene homolog B (Avian). (323 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
RPTNRPTN isoform 1. (733 aa)
FLGFLG isoform 1. (3364 aa)
IVLInvolucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia. (554 aa)
FOXQ1FOXQ1 isoform 1. (403 aa)
LIPKLipase; Belongs to the AB hydrolase superfamily. Lipase family. (399 aa)
LIPNLipase; Belongs to the AB hydrolase superfamily. Lipase family. (398 aa)
LTBLymphotoxin-beta; Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface (By similarity). (244 aa)
KRT81KRT81 isoform 1; Belongs to the intermediate filament family. (506 aa)
HDAC2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (581 aa)
APCDD1Adenomatosis polyposis coli down-regulated 1. (514 aa)
ANXA1Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of Fthe formyl peptide receptors (By similarity). Contribu [...] (346 aa)
COL5A2Collagen type V alpha 2 chain. (1499 aa)
FRAS1Fraser extracellular matrix complex subunit 1. (4012 aa)
ATP8A2Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1188 aa)
FOXE1FOXE1 isoform 1. (371 aa)
NSUN2NOP2/Sun domain family, member 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (767 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
FZD6Frizzled homolog 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa)
KRT1Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta 1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK (By similarity). (642 aa)
S100A7L2S100 calcium binding protein A7 like 2. (112 aa)
DSG4DSG4 isoform 2; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (1059 aa)
KRT78KRT78 isoform 2; Belongs to the intermediate filament family. (520 aa)
GLI2GLI family zinc finger 2. (1587 aa)
LDB1LIM domain binding 1. (411 aa)
BCRBCR activator of RhoGEF and GTPase. (1271 aa)
NSDHLNAD(P) dependent steroid dehydrogenase-like; Belongs to the 3-beta-HSD family. (373 aa)
EDAEctodysplasin A; Belongs to the tumor necrosis factor family. (391 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
LHX2LHX2 isoform 1. (406 aa)
KLF4Kruppel-like factor 4 (Gut). (479 aa)
ENSPTRP00000036205Keratin, type II cytoskeletal 8-like. (478 aa)
IFT74Intraflagellar transport 74 homolog. (600 aa)
ZDHHC21Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (265 aa)
PLECPLEC isoform 2. (4684 aa)
TBC1D31TBC1 domain family member 31. (1066 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
NOM1Nucleolar MIF4G domain-containing protein 1. (859 aa)
SMOSMO isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
COL1A2Collagen type I alpha 2 chain. (1366 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
DACT2Dishevelled binding antagonist of beta catenin 2. (774 aa)
LATS1LATS, large tumor suppressor, homolog 1. (1130 aa)
TRAF3IP2TRAF3 interacting protein 2. (574 aa)
SRFSerum response factor (C-fos serum response element-binding transcription factor). (508 aa)
DSPDSP isoform 1. (2871 aa)
ADAMTS2ADAM metallopeptidase with thrombospondin type 1 motif, 2. (1076 aa)
ARRDC3Arrestin domain containing 3. (414 aa)
AP3B1AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1045 aa)
FSTFST isoform 1. (344 aa)
INTUInturned planar cell polarity effector homolog. (911 aa)
EREGEREG isoform 1. (169 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
CSTACystatin A (Stefin A); Belongs to the cystatin family. (98 aa)
KRTAP21-1KRTAP21-1 isoform 1. (79 aa)
KRTAP6-1Keratin associated protein 6-1. (71 aa)
SOX18SOX18 isoform 1. (384 aa)
SLC2A10Solute carrier family 2 (Facilitated glucose transporter), member 10; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (541 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
IGFBP5Insulin-like growth factor-binding protein 5. (272 aa)
ABCA12ATP binding cassette subfamily A member 12. (2595 aa)
COL3A1Collagen type III alpha 1 chain. (1466 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (271 aa)
EDAREctodysplasin A receptor. (496 aa)
STARD7StAR-related lipid transfer (START) domain containing 7. (370 aa)
ASPRV1Aspartic peptidase retroviral like 1. (343 aa)
PUM2Pumilio RNA binding family member 2. (1065 aa)
KLK5Kallikrein related peptidase 5; Belongs to the peptidase S1 family. (293 aa)
FUZFuzzy planar cell polarity protein. (418 aa)
CNFNCNFN isoform 1. (125 aa)
COL5A3Collagen type V alpha 3 chain. (1745 aa)
ACER1Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (264 aa)
PIAS4Protein inhibitor of activated STAT protein 4. (510 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
GATA6GATA binding protein 6. (594 aa)
EVPLEVPL isoform 2. (2055 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
COL1A1Collagen type I alpha 1 chain. (1464 aa)
ITGA3ITGA3 isoform 6; Belongs to the integrin alpha chain family. (1066 aa)
DLX3Distal-less homeobox 3. (287 aa)
NGFRNerve growth factor receptor. (427 aa)
JUPJunction plakoglobin. (745 aa)
KRT17Keratin, type I cytoskeletal 17; Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair. May be a marker of basal cell differentiation in complex epit [...] (432 aa)
KRT9KRT9 isoform 1; Belongs to the intermediate filament family. (623 aa)
KRT10KRT10 isoform 1; Belongs to the intermediate filament family. (577 aa)
KRT27KRT27 isoform 1; Belongs to the intermediate filament family. (459 aa)
KRT25Keratin, type I cytoskeletal 25; Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs) (By similarity). Plays a role in the cytoskeleton organization (By similarity). (450 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1581 aa)
NF1Neurofibromin 1. (2839 aa)
FOXN1FOXN1 isoform 2. (648 aa)
KRT16KRT16 isoform 4; Belongs to the intermediate filament family. (485 aa)
LOC454470Keratin, type I cytoskeletal 17-like isoform X1. (437 aa)
ALOX12BALOX12B isoform 1. (701 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S type. (663 aa)
FA2HFatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...] (372 aa)
CDH3Cadherin 3, type 1, P-cadherin (Placental); Cadherins are calcium-dependent cell adhesion proteins. (829 aa)
PPLPPL isoform 2. (1756 aa)
DNASE1L2Deoxyribonuclease; Belongs to the DNase I family. (299 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
TGM1TGM1 isoform 1. (818 aa)
SLITRK5SLIT and NTRK like family member 5. (958 aa)
LATS2Non-specific serine/threonine protein kinase. (1088 aa)
ASCL4Achaete-scute family bHLH transcription factor 4. (173 aa)
HOXC13HOXC13 isoform 1. (330 aa)
KRT79KRT79 isoform 1; Belongs to the intermediate filament family. (643 aa)
KRT4KRT4 isoform 1; Belongs to the intermediate filament family. (608 aa)
KRT76KRT76 isoform 1; Belongs to the intermediate filament family. (640 aa)
KRT77KRT77 isoform 2; Belongs to the intermediate filament family. (583 aa)
KRT73KRT73 isoform 1; Belongs to the intermediate filament family. (540 aa)
KRT72KRT72 isoform 2; Belongs to the intermediate filament family. (511 aa)
KRT71KRT71 isoform 1; Belongs to the intermediate filament family. (523 aa)
KRT5Keratin, type II cytoskeletal 5; Belongs to the intermediate filament family. (592 aa)
KRT82KRT82 isoform 1; Belongs to the intermediate filament family. (513 aa)
KRT84KRT84 isoform 1; Belongs to the intermediate filament family. (600 aa)
KRT85KRT85 isoform 1; Belongs to the intermediate filament family. (507 aa)
CK820_G0039600KRT86 isoform 1; Belongs to the intermediate filament family. (469 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (546 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
YAP1Yes-associated protein 1. (508 aa)
OVOL1Ovo like transcriptional repressor 1. (267 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
LIPMLipase; Belongs to the AB hydrolase superfamily. Lipase family. (423 aa)
DKK1Dickkopf-like protein 1. (289 aa)
OPN3CHML isoform 2. (402 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
GORABGolgin, RAB6-interacting. (394 aa)
TMEM79Transmembrane protein 79. (394 aa)
ASH1LASH1 like histone lysine methyltransferase. (2969 aa)
SPRR3Small proline rich protein 3. (161 aa)
LCE1ALate cornified envelope 1A. (110 aa)
LCE3ALate cornified envelope 3A. (89 aa)
LCE3BLCE3B isoform 1. (95 aa)
LCE3CLate cornified envelope 3C. (94 aa)
LCE5ALCE5A isoform 1. (118 aa)
TXNIPArrestin_C domain-containing protein. (391 aa)
DHCR2424-dehydrocholesterol reductase. (516 aa)
KDF1Keratinocyte differentiation factor 1. (398 aa)
STMN1Stathmin; Belongs to the stathmin family. (174 aa)
CLIC4Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (253 aa)
EPHA2EPH receptor A2. (976 aa)
ERRFI1ERBB receptor feedback inhibitor 1. (462 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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